Results 21 to 30 of about 23,485 (167)

A thermostable β-glucuronidase obtained by directed evolution as a reporter gene in transgenic plants.

PLoS ONE, 2011
A β-glucuronidase variant, GUS-TR3337, that was obtained by directed evolution exhibited higher thermostability than the wild-type enzyme, GUS-WT. In this study, the utility of GUS-TR337 as an improved reporter was evaluated. The corresponding gus-tr3337
Ai-Sheng Xiong, Ri-He Peng, Jing Zhuang, Jian-Min Chen, Bin Zhang, Jian Zhang, Quan-Hong Yao   +6 more
doaj   +1 more source

Theoretical investigation and design of some indole derivatives as potent β-glucuronidase inhibitors

Bulletin of the National Research Centre, 2020
Background β-glucuronidase enzyme is mostly found in plants and animals. It plays a vital role in detoxification of reactive metabolites that are interrelated to several illnesses and the growth of colon cancer.
Muhammad Tukur Ibrahim, Salisu Muhammad Tahir, Abdullahi Bello Umar, Usman Abdulfatai   +3 more
doaj   +1 more source

Upregulation of Jasmonate-Inducible Defense Proteins and Differential Colonization of Roots of Oryza sativa Cultivars with the Endophyte Azoarcus sp.

Molecular Plant-Microbe Interactions, 2006
The endophyte Azoarcus sp. strain BH72 expresses nitrogenase (nif) genes inside rice roots. We applied a proteomic approach to dissect responses of rice roots toward bacterial colonization and jasmonic acid (JA) treatment.
Lucie Miché, Federico Battistoni, Sabrina Gemmer, Maya Belghazi, Barbara Reinhold-Hurek   +4 more
doaj   +1 more source

Tethered Indoxyl-Glucuronides for Enzymatically Triggered Cross-Linking

Molecules, 2023
Indoxyl-glucuronides, upon treatment with β-glucuronidase under physiological conditions, are well known to afford the corresponding indigoid dye via oxidative dimerization.
Juno Son, Zhiyuan Wu, Jinghuai Dou, Hikaru Fujita, Phuong-Lien Doan Cao, Qihui Liu, Jonathan S. Lindsey   +6 more
doaj   +1 more source

In Silico Structural Analysis of Human β-Glucuronidase for Antibody-Drug Conjugates Optimization. [PDF]

Proteins
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Canini G, Saporiti S, Coppa C, Rossi M, Centola F, Arcovito A.   +5 more
europepmc   +2 more sources

Lactate Dehydrogenase and β-Glucuronidase as Salivary Biochemical Markers of Periodontitis Among Smokers and Non-Smokers

Sultan Qaboos University Medical Journal, 2018
Objectives: This study aimed to establish lactate dehydrogenase (LDH) and β-glucuronidase as salivary biomarkers of periodontitis among smokers and non-smokers.
Syed A. Ali, Ravi L. Telgi, Amit Tirth, Irfan Q. Tantry, Abdul Aleem   +4 more
doaj   +1 more source

Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors

Molecules, 2014
Phenoxyacetohydrazide Schiff base analogs 1–28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 ± 0.32 µM), 5 (IC50 = 9.47 ± 0.16 µM), 7 (IC50 = 14.7 ± 0.19 µM), 8 (IC50 = 15.4 ± 1.56 µM),
Waqas Jamil, Shagufta Perveen, Syed Adnan Ali Shah, Muhammad Taha, Nor Hadiani Ismail, Shahnaz Perveen, Nida Ambreen, Khalid M. Khan, Muhammad I. Choudhary   +8 more
doaj   +1 more source

Continuous Spectrophotometric Assay for β-Glucuronidase

BioTechniques, 2001
A continuous spectrophotometric assay has been developed for detecting β-glucuronidase activity. In the assay, Para-nitrophenyl β-d-glucuronide is cleaved to yield a chromophoric product. With the commercial E.
Sanjukta Aich, Louis T.J. Delbaere, Ridong Chen   +2 more
doaj   +1 more source

Rational Design, Synthesis, In Vitro, and In Silico Studies of Dihydropyrimidinone Derivatives as β-Glucuronidase Inhibitors

Journal of Chemistry, 2021
In the current study, a series of dihydropyrimidinone derivatives were rationally designed as β-glucuronidase inhibitors. These designed compounds were successfully synthesized and characterized through various spectroscopic techniques such as IR, 1H-NMR,
Somaye Karimian, Yasaman Moghdani, Mahsima Khoshneviszadeh, Somayeh Pirhadi, Aida Iraji, Mehdi Khoshneviszadeh   +5 more
doaj   +1 more source

MOESM1 of Indole bearing thiadiazole analogs: synthesis, β-glucuronidase inhibition and molecular docking study

, 2019
Additional file 1. Supporting data having proton NMR of all compounds.
Almandil, Noor, Taha, Muhammad, Gollapalli, Mohammed, Fazal Rahim, Ibrahim, Mohamed, Ashik Mosaddik, Anouar, El   +6 more
openaire   +1 more source