Results 1 to 10 of about 85,033 (176)

Parabacteroides distasonis promotes liver regeneration by increasing β-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals [PDF]

Acta Pharmaceutica Sinica B
The liver regenerative capacity is crucial for patients with end-stage liver disease following partial hepatectomy (PHx). The specific bacteria and mechanisms regulating liver regeneration post-PHx remain unclear.
Manlan Guo, Xiaowen Jiang, Hui Ouyang, Xianglong Zhang, Shuaishuai Zhang, Peng Wang, Guofang Bi, Ting Wu, Wenhong Zhou, Fengting Liang, Xiao Yang, Shicheng Fan, Jian-hong Fang, Peng Chen, Huichang Bi   +14 more
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Dietary β-hydroxybutyric acid improves the growth performance of young ruminants based on rumen microbiota and volatile fatty acid biosynthesis [PDF]

Frontiers in Microbiology, 2023
IntroductionThe ketone body β-hydroxybutyric acid (BHB) plays critical roles in cellular proliferation and metabolic fuel utilization; however, its effects on the rumen microbiota remain unknown.MethodsHere, three doses of BHB (low, medium, and high ...
Jianmin Chai, Jianmin Chai, Jianmin Chai, Zeyue Liu, Jun Wu, Yuan Kang, Mahmoud M. Abdelsattar, Wei Zhao, Shiqin Wang, Shuli Yang, Feilong Deng, Ying Li, Yimin Zhuang, Yimin Zhuang, Naifeng Zhang   +14 more
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The Dynamic Transcription Profiles of Proliferating Bovine Ovarian Granulosa When Exposed to Increased Levels of β-Hydroxybutyric Acid [PDF]

Frontiers in Veterinary Science, 2022
Ketosis is common in high-yield dairy cows. It is a condition that is characterized by the accumulation of serum β-hydroxybutyric acid (BHBA). Both subclinical ketosis and clinical ketosis can compromise the reproductive performance and cause long ...
Jianfei Gong, Shanjiang Zhao, Nuo Heng, Yi Wang, Zhihui Hu, Huan Wang, Huabin Zhu   +6 more
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Caloric Restriction Alleviates CFA-Induced Inflammatory Pain via Elevating β-Hydroxybutyric Acid Expression and Restoring Autophagic Flux in the Spinal Cord [PDF]

Frontiers in Neuroscience, 2022
Inflammatory pain is the most common type of pain encountered in clinical practice; however, the currently available treatments are limited by insufficient efficacy and side effects.
Chang Liu, Chang Liu, Xiaoting Zheng, Xiaoting Zheng, Lifang Liu, Lifang Liu, Yun Hu, Yun Hu, Qianyun Zhu, Qianyun Zhu, Jiawei Zhang, Jiawei Zhang, Huan Wang, Huan Wang, Er-wei Gu, Er-wei Gu, Zhilai Yang, Zhilai Yang, Zhilai Yang, Guanghong Xu, Guanghong Xu   +20 more
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Danggui Buxue decoction alleviates cyclophosphamide-induced myelosuppression by regulating β-hydroxybutyric acid metabolism and suppressing oxidative stress [PDF]

Pharmaceutical Biology, 2023
Context Danggui Buxue Decoction (DBD) is an effective complementary medicine in alleviating myelosuppression after chemotherapy (MAC). However, its mechanism of action is elusive.Objective To illustrate that regulating β-hydroxybutyric acid (β-OHB ...
Yiqiao Gao, Yixin Zhang, Wei Liu, Nan Zhang, Qinghe Gao, Jingfang Shangguan, Na Li, Ying Zhao, Yanlong Jia   +8 more
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The relationship between plasma β-hydroxybutyric acid and conjugated linoleic acid in milk as a biomarker for early diagnosis of ketosis in postpartum Polish Holstein-Friesian cows [PDF]

BMC Veterinary Research, 2019
Background The aim of this study was to investigate the association between plasma β-hydroxybutyric acid (BHBA) and conjugated linoleic acid in postpartum Polish Holstein-Friesian (PHF) cows.
Kamila Puppel, Marcin Gołębiewski, Paweł Solarczyk, Grzegorz Grodkowski, Jan Slósarz, Małgorzata Kunowska-Slósarz, Marek Balcerak, Tomasz Przysucha, Aleksandra Kalińska, Beata Kuczyńska   +9 more
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β-Hydroxybutyric acid improves cognitive function in a model of heat stress by promoting adult hippocampal neurogenesis [PDF]

Stress Biology, 2022
Heat stress has multiple potential effects on the brain, such as neuroinflammation, neurogenesis defects, and cognitive impairment. β-hydroxybutyric acid (BHBA) has been demonstrated to play neuroprotective roles in various models of neurological ...
Jian Huang, Yongji Wu, Xuejun Chai, Shuai Wang, Yongkang Zhao, Yan Hou, Yue Ma, Shulin Chen, Shanting Zhao, Xiaoyan Zhu   +9 more
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Sirtuin 3 regulation: a target to alleviate β-hydroxybutyric acid-induced mitochondrial dysfunction in bovine granulosa cells [PDF]

Journal of Animal Science and Biotechnology, 2023
Background During the transition period, the insufficient dry matter intake and a sharply increased in energy consumption to produce large quantities of milk, high yielding cows would enter a negative energy balance (NEB) that causes an increase in ...
Shanjiang Zhao, Jianfei Gong, Yi Wang, Nuo Heng, Huan Wang, Zhihui Hu, Haoyu Wang, Haobo Zhang, Huabin Zhu   +8 more
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Ketone body therapy with D/L-β-hydroxybutyric acid solution in severe MADD [PDF]

Molecular Genetics and Metabolism Reports, 2019
Objectives: Multiple acyl-CoA dehydrogenase deficiency (MADD) is a severe inborn disorder of mitochondrial fatty acid oxidation. The only treatment option for MADD is the use of exogenous ketone bodies, like sodium β-hydroxybutyrate (NaβHB). However, the
Tobias Fischer, Christiane Elpers, Ulrike Och, Manfred Fobker, Thorsten Marquardt   +4 more
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Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy [PDF]

Cell Discovery
Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which the KD exerts its antiepileptic efficacy remain elusive.
Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-Xin Yang, Zhen-Zhen Ma, Lin Huang, Yan-Peng An, Yi-Yuan Yuan, Yan Lin, Wei Xu, Yao Li, Peng-Cheng Lin, Jing Cao, Jian-Yuan Zhao, Shi-Min Zhao   +14 more
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