Results 21 to 30 of about 85,033 (176)

β-hydroxybutyrate impairs monocyte function via the ROS-NLR family pyrin domain-containing three inflammasome (NLRP3) pathway in ketotic cows

open access: yesFrontiers in Veterinary Science, 2022
Cows with ketosis display severe metabolic stress and immune dysfunction which renders them more susceptible to infections. Monocytes, one of the major subtypes of white blood cells, play an important role in innate immune defense against infections ...
Zhihao Dong   +9 more
doaj   +1 more source

Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders

open access: yesFrontiers in Psychiatry, 2023
In recent times, advances in the field of metabolomics have shed greater light on the role of metabolic disturbances in neuropsychiatric conditions. The following review explores the role of ketone bodies and ketosis in both the diagnosis and treatment ...
Naomi Elyse Omori   +3 more
doaj   +1 more source

Investigation of changes in metabolic parameters and paraoxonase-1 during the transition period in turkish saanen goats [PDF]

open access: yesKafkas Universitesi Veteriner Fakültesi Dergisi, 2017
The aim of this study was to evaluate the metabolic changes and PON-1 levels in Turkish Saanen goats during the transition period. In the study, 60 Turkish Saanen goats were used and blood samples were taken from the jugular vein on days -30, -15, 0, +15,
Seçkin SALAR   +4 more
doaj   +1 more source

Ketone Bodies Inhibit the Opening of Acid-Sensing Ion Channels (ASICs) in Rat Hippocampal Excitatory Neurons in vitro

open access: yesFrontiers in Neurology, 2019
Objectives: Despite the long-term efficacy of antiepileptic drug treatments, frequent attacks of drug-resistant epilepsy necessitate the development of new antiepileptic drug therapy targets.
Fei Zhu   +18 more
doaj   +1 more source

Function and treatment strategies of β-hydroxybutyrate in aging

open access: yesSmart Materials in Medicine, 2023
Metabolic intermediates serve as precursors for bioactive molecule synthesis, the energy source for life activities, and signals for environmental adaptation. Ketone bodies are important metabolic intermediates produced in the liver by the degradation of
Yang Xiang   +4 more
doaj   +1 more source

The Mechanisms of Catalysis by Metallo β-Lactamases [PDF]

open access: yes, 2008
Class B β-lactamases or metallo-β-lactamases (MBLs) require zinc ions to catalyse the hydrolysis of β-lactam antibiotics such as penicillins, cephalosporins, carbapenems, and cephamycins.
Michael I. Page   +3 more
core   +1 more source

Study on the relationship of acute ketosis intoxication and type 2 diabetes mellitus

open access: yesJournal of Acute Disease, 2016
Objective: To study the change of serum C-reactive protein (CRP) levels and its correlation with ketosis in type 2 diabetes mellitus patients with acute ketosis intoxication.
Tian-Xiao Hu   +7 more
doaj   +1 more source

Search for serum biomarkers in patients with bipolar disorder and major depressive disorder using metabolome analysis

open access: yesFrontiers in Psychiatry, 2023
ObjectiveBipolar disorder (BD) and major depressive disorder (MDD) are two common psychiatric disorders. Due to the overlapping clinical symptoms and the lack of objective diagnostic biomarkers, bipolar disorder (BD) is easily misdiagnosed as major ...
Xiao-Li Sun   +12 more
doaj   +1 more source

Agro-Industrial Waste Materials as Substrates for the Production of Poly(3-Hydroxybutyric Acid) [PDF]

open access: yes, 2014
Accumulation of recalcitrant plastics in the environment has become a world-wide problem in today’s societies. Rapid depletion of natural resources for synthetic plastics along with environmental concerns has directed research towards finding ...
Roy, I., Keshavarz, T., Sukan, A.
core   +1 more source

Gas Chromatography–Mass Spectroscopy-Based Metabolomics Analysis Reveals Potential Biochemical Markers for Diagnosis of Gestational Diabetes Mellitus

open access: yesFrontiers in Pharmacology, 2021
Due to many adverse effects of gestational diabetes mellitus (GDM) on the mother and fetus, its diagnosis is crucial. The presence of GDM can be confirmed by an abnormal fasting plasma glucose level (aFPG) and/or oral glucose tolerance test (OGTT ...
Beata A. Raczkowska   +12 more
doaj   +1 more source

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