Results 131 to 140 of about 144,498 (294)

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source

Interaction of β-lactam antibiotics with penicillin-binding proteins fromPseudomonas aeruginosa [PDF]

FEMS Microbiology Letters, 1982
Alfredo Rodriguez-Tebár, Fernando Rojo, Juan C. Montilla, David Vázquez   +3 more
openaire   +1 more source

Detection of extended spectrum B-lactamases in urinary isolates of Klebsiella pneumoniae in relation to Bla SHV, Bla TEM and Bla CTX-M gene carriage [PDF]

, 2011
Background: Resistance to contemporary broad-spectrum β-lactam antibiotics mediated by extended-spectrum β-lactamases (ESBLs) is increasing worldwide.
Eftekhar, F., Golalipoor, M., Mansoursamaei, N., Rastegar, M.   +3 more
core   +1 more source

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) [PDF]

, 2016
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.
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core   +4 more sources

Green Synthesis of ZnO Nanoparticles From Spirulina platensis: Antimicrobial and Cytotoxic Evaluation With Molecular Docking Studies

ChemistryOpen, EarlyView.
Algal‐extract‐derived ZnO nanoparticles show shape anisotropy and are bio capped by phytochemicals. These green‐synthesized NPs strongly inhibit S. aureus and K. pneumoniae biofilms. Molecular docking suggests stable binding of surface biomolecules to microbial targets, highlighting synergistic antibacterial mechanisms.
Muhammad Rizwan, Izaz Khan, Syed Sikandar Shah, Amir hamza khan, Abdurahman Hajinur Hirad, Saira Naz, Arshad Farid, Taimoor Khan, Said Hassan   +8 more
wiley   +1 more source

The Mechanism of Emodin Against Methicillin-Resistant Staphylococcus aureus Infection and Research on Synergistic Antibiotics

Life
Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant clinical challenge due to its multidrug resistance, particularly to β-lactam antibiotics.
Chenliang Chu, Liang Qin, Huayong Peng, Tao Kuang, Yongshi Li, Xin Wang, Fenglan Liang, Ping Gao, Xiaoxiong Wang, Deyun Ma   +9 more
doaj   +1 more source

Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina [PDF]

, 2014
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) emerged at the Pediatric Hospital of Misiones Province, north Argentina, in 2003 as a cause of community-acquired (CA) infections, mostly associated with skin and soft tissue infections ...
Gardella, Noella Mariel, Grenon, Sandra Liliana, Gutkind, Gabriel Osvaldo, Mollerach, Marta Eugenia, Ubeda, Clotilde, Von Specht, Martha Helena   +5 more
core   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

One-step degradation of 4 classes of β-lactam using β-lactamase enzyme cocktail

Scientific Reports
Antibiotics, particularly β-lactams, are emerging environmental contaminants that induce antibiotic-resistant bacteria or genes, which threaten public health. Enzymatic degradation is an environmentally friendly approach to reducing residual antibiotics;
Jiafu Lin, Tiantian Wang, Yaliang Zhou, Tao Cheng, Haisha Liu, Xueke Chen, Wan Luo, Qiyue Liu, Yiwen Chu, Xinrong Wang, Feng Xie, Jingzhou Sha, Tao Song   +12 more
doaj   +1 more source

Characterizing Scales of Genetic Recombination and Antibiotic Resistance in Pathogenic Bacteria Using Topological Data Analysis

, 2014
Pathogenic bacteria present a large disease burden on human health. Control of these pathogens is hampered by rampant lateral gene transfer, whereby pathogenic strains may acquire genes conferring resistance to common antibiotics. Here we introduce tools
A. Holzinger, C. Fraser, C.M. Thomas, C.R. Woese, F. Meyer, G. Carlsson, H. Ochman, H. Rohde, H.C. Neu, J.E. Cooper, J.M. Chan, K.A. Jolley, M.O. Sommer, T. Dagan   +13 more
core   +1 more source