Results 141 to 150 of about 61,324 (269)
, 2005 The increasing emergence of new bacterial β-lactamases that can efficiently hydrolyze β-lactam antibiotics to clinically inactive carboxylic acids has created an intractable problem in the treatment of bacterial infections, and it is highly desirable to ...
Pak-Ho Chan +11 more
core +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim To synthesise evidence on the effectiveness, harms and benefits of different approaches to prevent early‐onset Group B Streptococcus (EOGBS) and identify gaps in short and longer‐term outcomes. Methods A two‐phase rapid review. Phase 1 included an overview of systematic reviews (SRs).
Pauline Campbell +12 more
wiley +1 more source
β-lactam-induced OMV release promotes polymyxin tolerance in Salmonella enterica sv. Typhi
Frontiers in MicrobiologyThe rise of multidrug-resistant bacteria is a global concern, leading to a renewed reliance on older antibiotics like polymyxins as a last resort. Polymyxins, cationic cyclic peptides synthesized nonribosomally, feature a hydrophobic acyl tail and ...
Pedro Marchant +9 more
doaj +1 more source
A calorimetric study of β-sultams and β-lactams
The hydrolytic degradation of a series of β-sultams and β-lactams was investigated using isothermal microcalorimetry (IMC), to determine kinetic and enthalpic data.
Naz, Summia
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, 1991 The kinetics of both intracellular and extracellular β-lactamase production and the relationship between extracellular enzyme and in vitro susceptibility of Mycobacterium fortuitum to beta-lactam antibiotics have been studied. To this end we used a panel
Shao Hong Jin, Null +6 more
core +1 more source
, 2016 The increasing emergence of new bacterial β-lactamases that can efficiently hydrolyze β-lactam antibiotics to clinically inactive carboxylic acids has created an intractable problem in the treatment of bacterial infections, and it is highly desirable to ...
Hong-Bing Liu (1689937) +5 more
core +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Mechanistic studies of some chemical and biochemical reactions
Three aspects of chemical and biochemical reactions were investigated. 1. The relative reactivities of pyrophosphate (phosphorus(V)) and pyro-di-H-phosphonate (phosphorus(III)) and its derivatives have been analysed at various pHs.
Mistry, Dharmit
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Quality and Consistency of Penicillin Allergy Delabelling Guidelines: A Systematic Review
Clinical &Experimental Allergy, EarlyView.Eighteen penicillin allergy delabelling guidelines from 12 countries were reviewed. There is consensus for staged risk‐based testing, with emerging support for direct oral challenge in low‐risk patients and expanded non‐specialist roles. Overall guideline quality was low, with major gaps in methodological rigour, stakeholder involvement, and ...
Jessie He +8 more
wiley +1 more source
Streptococcus pneumoniae, the pneumococcus, is a cause of major illness globally. Invasive pneumococcal disease (IPD) is characterized by pneumococci invading blood (bacteremia), lungs (pneumonia), or brain and cerebrospinal fluid (meningitis ...
Niels Vander Elst (18652594) +4 more
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