Results 131 to 140 of about 1,201,054 (248)

Evaluation of drug-drug interaction between nacubactam and β-lactam antibiotic (cefepime, aztreonam, meropenem, or piperacillin) in Japanese healthy participants

Antimicrobial Agents and Chemotherapy
We conducted an open-label study to assess the pharmacokinetics, safety, and tolerability of nacubactam—a β-lactamase inhibitor—administered alone or in combination with β-lactam antibiotic.
Jun Morita, Hiroki Sato, Masayo Sumiya, Risako Takaya, Kazuya Ishiwata, Shogo Matsumoto, Takuma Yonemura, Yuji Kumagai   +7 more
doaj   +1 more source

Sodium deoxycholate synergistically enhances the antimicrobial activity of β-lactam antibiotics againstβ-lactamase-producing Staphylococcus aureus [PDF]

, 2012
Background β-lactamase-producing Staphylococcus aureus synthesizes a β-lactamase which decomposes the β-lactam ring, and consequently almost all β-lactam antibiotics are inactivated by the enzyme. The appearance of β-lactamase-producing bacterial strains
Yamada, Akira, Yoshida, Sayuri, Yaegashi, Asaka, Fujii, Yuichi, Hirano, Kano, Nozawa, Koohei, Tanaka, Satomi, Yamaki, Fumiko, Horie, Hitoshi   +8 more
core  

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

β-Lactam/β-Lactamase Inhibitor Combination Antibiotics Under Development

Pathogens
Antimicrobial resistance remains a public health problem of global concern with a great health and financial burden. Its recognition as a threat by political leadership has boosted the research and development of new antibiotics and particularly novel ...
Angeliki Katsarou, Panagiotis Stathopoulos, Iva D. Tzvetanova, Christina-Maria Asimotou, Matthew E. Falagas   +4 more
doaj   +1 more source

Mechanistic insights into HipA‐mediated bacterial persistence: Role of initial cellular states and toxin expression kinetics

mLife, EarlyView.
Abstract Persistent bacteria subpopulations showing multidrug tolerance pose significant challenges to antibiotic therapy. While the HipBA toxin–antitoxin (TA) system is known to play a role in persister formation, existing studies predominantly focus on its kinase activity and intracellular regulatory pathways, with limited attention to the ...
Jing Zhao, Yixiao Xiong, Hongxia Zhao, Jin Wang, Xiaona Fang   +4 more
wiley   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

Impact of the GouM transporter on secondary metabolism activation and production yield in Streptomyces noursei strain CK‐15

New Plant Protection, EarlyView.
Overexpression of the gouM transporter gene in Streptomyces noursei CK‐15 enhances gougerotin production by 114% and activates silent biosynthetic gene clusters. This finding links transporter activity to metabolite efflux and secondary metabolism, offering a strategy for natural product discovery and strain optimization.
Qianying Zhou, Hua Yu, Rouhallah Sharifi, Muhammad Usman, Shun Lai Ei, Abdel‐Hamied M. Rasmey, Beibei Ge   +6 more
wiley   +1 more source

Biocontrol and plant growth‐promoting potential of Streptomyces strains against fungal pathogens of tomato and wheat for a sustainable agriculture

Pest Management Science, EarlyView.
This study highlights the biocontrol potential of Streptomyces strain Strep_22. In vitro, it inhibits key fungal pathogens by 91.52%. In vivo, it significantly reduces disease incidence in wheat and tomato while enhancing biomass, shoot, and root development, offering a highly promising, sustainable ecological alternative to chemical pesticides ...
Thomas Conte, Maria Grazia Morea, Gaetana Ricciardi, Angelo Pastino, Francesco Lops, Maria Luisa Raimondo, Antonia Carlucci   +6 more
wiley   +1 more source

Inhibition of Granulopoiesis in Vivo and in Vitro by β-Lactam Antibiotics [PDF]

, 2017
β-Lactam antibiotics can induce severe neutropenia by a hitherto unknown mechanism. Fifty cases of β-lactam antibiotic-induced neutropenia (15% in patients treated for ⩾10 days with large doses of any β-lactam antibiotic but 95% of cases recovery ...
Müller, Marianne R., Neftel, Klaus A., Hauser, Simon P.   +2 more
core  

Discovery of edodine, a natural compound from Lentinula edodes with antibacterial activity for the biological control of fire blight pathogen Erwinia amylovora

Pest Management Science, EarlyView.
Novel edodine was identified from Lentinula edodes HK761, exhibiting biocontrol potential against fire blight by affecting motility, intracellular ATP level, and cell division of Erwinia amylovora. Abstract BACKGROUND In the search for biological resources with antibacterial activity against Erwinia amylovora, the culture filtrate of Lentinula edodes ...
Yeong Seok Kim, Jae Woo Han, Bomin Kim, Chunggeon Lee, Daeui Park, Jaehyuk Choi, Gyung Ja Choi, Hun Kim   +7 more
wiley   +1 more source