Results 131 to 140 of about 61,324 (269)

New immunosensor for β-lactam antibiotics determination in river waste waters

, 2014
The aim of the present research was to develop a single use, simple but highly sensitive amperometric immunosensor for penicillin G and other β-lactam antibiotics based on a “competitive assay”.
MEROLA, GIOVANNI, MARTINI, ELISABETTA, TOMASSETTI, Mauro, CAMPANELLA, Luigi   +3 more
core   +1 more source

Reusing health records from farm animal practices at scale: A potential complementary method of surveillance

Veterinary Record, EarlyView.
Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins, Peers Davies, Peter‐John Noble, Anna Bunford‐Davies, April Lawson, Gina Pinchbeck, Ifan Lloyd, Robert Smith, Alan D. Radford   +8 more
wiley   +1 more source

Enhancement effects of antimicrobial activities of β-lactam antibiotics by combination with persimmon tannin against β-lactamase-producing Staphylococcus aureus [PDF]

, 2010
Background　β-lactamase-producing Staphylococcus　aureus is one of the most important bacterial pathogens. Combinations of β-lactam antibiotics with β-lactamase inhibitors such as sulbactam and tazobactam are useful therapeutic methods for combating ...
Yamada, Akira, Iwama, Masanori, Fujii, Yuichi, Sato, Hiroyasu, Hamada, Setsuo, Nozawa, Koohei, Horie, Hitoshi, Taya, Kahoru   +7 more
core  

The enzymes of β-lactam biosynthesis.

, 2013
The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via ...
Gomez-Castellanos, JR, J. Ruben Gomez-Castellanos, Refaat B. Hamed, Hamed, RB, Christian Ducho, Ducho, C, Luc Henry, Michael A. McDonough, Schofield, CJ, McDonough, MA, Henry, L, Schofield, Christopher, Christopher J. Schofield   +12 more
core   +1 more source

Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy

Allergy, EarlyView.
DeAns with defined nanoscale structure reveal that conjugate size and determinant density govern IgE‐mediated effector‐cell activation in AX allergy. All DeAn generations bind to sIgE in inhibition immunoassay, but only larger DeAns trigger FcεRI‐dependent responses in mouse MC, huRBL‐2H3, and LUVA cells.
Amene Tesfaye Ayane, Maria Salas, Sara Benede, Maria J. Rodriguez‐Sanchez, Maria J. Rodriguez‐Sojo, Isabel M. Jiménez‐Sánchez, Gador Bogas, Ezequiel Perez‐Inestrosa, Cristobalina Mayorga, Juan L. Paris, Alba Rodríguez‐Nogales, María J. Torres, María I. Montañez   +12 more
wiley   +1 more source

β-Lactam/β-Lactamase Inhibitor Combination Antibiotics Under Development

Pathogens
Antimicrobial resistance remains a public health problem of global concern with a great health and financial burden. Its recognition as a threat by political leadership has boosted the research and development of new antibiotics and particularly novel ...
Angeliki Katsarou, Panagiotis Stathopoulos, Iva D. Tzvetanova, Christina-Maria Asimotou, Matthew E. Falagas   +4 more
doaj   +1 more source

β-lactam-induced MRSA biofilm

, 2014
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital- and community-associated infections. The formation of adherent clusters of cells known as biofilms is an important virulence factor in MRSA pathogenesis.
Piotrowski, Brian O., Callahan, Mary T., Roberts, Afsoon D., Keiser, John F., Ng, Mandy, Epstein, Samuel B., Kaplan, Jeffrey B., Simon, Gary L.   +7 more
core  

Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin

Allergy, EarlyView.
This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes, Clara Lebrón‐Martín, Lucía Vallecillos‐Azor, Pablo Torres, Amene Tesfaye Ayane, Gádor Bogas, María Salas, Adriana Ariza, María Isabel Montañez, María José Torres, Carlos José Aranda, Cristobalina Mayorga   +11 more
wiley   +1 more source

The interactive antimicrobial activities of selected South African Terminalia spp. extracts in combination with conventional antibiotics against methicillin and β-lactam resistant pathogens

The decline in antibiotic discoveries and the rise in antibiotic resistance have rendered many antibiotics ineffective against bacterial infections. To address this challenge, researchers are exploring combinatorial therapies that blend medicinal plants ...
Cheesman, Matthew James, Cock, Ian Edwin, Zai, Muhammad Jawad Yousaf   +2 more
core   +1 more source

Hypersensitivity to Excipients in Drugs: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Drugs contain active pharmaceutical ingredients and excipients, compounds which enhance the pharmacokinetics, stability and palatability of the pharmaceutical formulation. While most drug hypersensitivity reactions (DHR) are caused by active ingredients, excipients may also be involved.
Lene H. Garvey, Knut Brockow, Annick Barbaud, Charlotte G. Mortz, Gianfranco Calogiuri, Asli Gelincik, Osman O. Yeğit, Alla Nakonechna, Annette Wagner, Rik Schrijvers, Toon Ieven   +10 more
wiley   +1 more source