Results 1 to 10 of about 74,609 (245)

Molecular Determinants of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus (MRSA): An Updated Review [PDF]

Antibiotics, 2023
The development of antibiotic resistance in Staphylococcus aureus, particularly in methicillin-resistant S. aureus (MRSA), has become a significant health concern worldwide.
Harshad Lade, Jae-Seok Kim
doaj   +2 more sources

Effect of β-Lactamase inhibitors on in vitro activity of β-Lactam antibiotics against Burkholderia cepacia complex species [PDF]

Antimicrobial Resistance and Infection Control, 2016
Background Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients.
Annelien Everaert, Tom Coenye
doaj   +4 more sources

A Nonclassical Mechanism of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus and Its Effect on Virulence [PDF]

Microbiology Spectrum, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) is a group of pathogenic bacteria that are infamously resistant to β-lactam antibiotics, a property attributed to the mecA gene.
Nidhi Satishkumar, Li-Yin Lai, Nagaraja Mukkayyan, Bruce E. Vogel, Som S. Chatterjee   +4 more
doaj   +2 more sources

Identification of host genetic factors modulating β-lactam resistance in Escherichia coli harbouring plasmid-borne β-lactamase through transposon-sequencing [PDF]

Emerging Microbes and Infections
Since β-lactam antibiotics are widely used, emergence of bacteria with resistance to them poses a significant threat to society. In particular, acquisition of genes encoding β-lactamase, an enzyme that degrades β-lactam antibiotics, has been a major ...
Hyunhee Kim, Travis Bell, Kihyun Lee, Jeongyun Jeong, James C. A. Bardwell, Changhan Lee   +5 more
doaj   +2 more sources

Detection of β-lactam resistance genes in Gram-negative bacteria from positive blood cultures using a microchip-based molecular assay [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundAccurate detection of β-lactam resistance genes in bloodstream infections is critical for guiding antimicrobial therapy. This study evaluates the Alifax Gram-negative resistance (GNR) microchip assay for detecting β-lactam resistance genes ...
Vittorio Ivagnes, Flavio De Maio, Ilaria Baccani, Alberto Antonelli, Giulia Menchinelli, Roberto Rosato, Giordana Cafaro, Giulia Santarelli, Federico Falletta, Tiziana D’Inzeo, Tiziana D’Inzeo, Maurizio Sanguinetti, Maurizio Sanguinetti, Teresa Spanu, Giulia De Angelis, Giulia De Angelis, Gian Maria Rossolini, Gian Maria Rossolini, Brunella Posteraro, Brunella Posteraro   +19 more
doaj   +2 more sources

Hypericin enhances β-lactam antibiotics activity by inhibiting sarA expression in methicillin-resistant Staphylococcus aureus [PDF]

Acta Pharmaceutica Sinica B, 2019
Bacteremia is a life-threating syndrome often caused by methicillin-resistant Staphylococcus aureus (MRSA). Thus, there is an urgent need to develop novel approaches to successfully treat this infection.
Genzhu Wang, Liang Li, Xiukun Wang, Xue Li, Youwen Zhang, Jie Yu, Jiandong Jiang, Xuefu You, Yan Q. Xiong   +8 more
doaj   +3 more sources

Exploration of the role of the penicillin binding protein 2c (Pbp2c) in inducible β-lactam resistance in Corynebacteriaceae [PDF]

Frontiers in Microbiology
Six genes encoding putative high molecular weight penicillin-binding proteins (Pbp) are present in the genome of the β-lactam-resistant strain Corynebacterium jeikeium K411.
Marie Lavollay, Marie Lavollay, Marie Lavollay, Céline Buon, Vincent Le Moigne, Fabrice Compain, Armel Guyonvarch, Matthieu Fonvielle   +7 more
doaj   +2 more sources

β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward

Frontiers in Microbiology, 2023
β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial agents for treating both Gram-negative and Gram-positive bacterial infections.
Lekshmi Narendrakumar, Medha Chakraborty, Shashi Kumari, Deepjyoti Paul, Bhabatosh Das   +4 more
doaj   +1 more source

Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics

mBio, 2023
The purine-derived signaling molecules c-di-AMP and (p)ppGpp control mecA/PBP2a-mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise the possibility that purine availability can control antibiotic susceptibility ...
Aaron C. Nolan, Merve S. Zeden, Igor Kviatkovski, Christopher Campbell, Lucy Urwin, Rebecca M. Corrigan, Angelika Gründling, James P. O’Gara   +7 more
doaj   +1 more source

Detection of an IS21 insertion sequence in the mexR gene of Pseudomonas aeruginosa increasing β-lactam resistance [PDF]

FEMS Microbiology Letters, 2004
To understand the regulation of the MexAB OprM efflux system in a clinical strain of Pseudomonas aeruginosa presenting a decreased susceptibility to ticarcillin and aztreonam, the mexR repressor gene was amplified by polymerase chain reaction (PCR) and was shown to be disrupted by an insertion sequence of more than 2 kb, with characteristic direct and ...
Boutoille, David, Corvec, Stéphane, Caroff, Nathalie, Giraudeau, Cécile, Espaze, Eric, Caillon, Jocelyne, Plesiat, Patrick, Reynaud, Alain   +7 more
openaire   +2 more sources