Results 1 to 10 of about 45,124 (122)

A Nonclassical Mechanism of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus and Its Effect on Virulence [PDF]

Microbiology Spectrum, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) is a group of pathogenic bacteria that are infamously resistant to β-lactam antibiotics, a property attributed to the mecA gene.
Nidhi Satishkumar, Li-Yin Lai, Nagaraja Mukkayyan, Bruce E. Vogel, Som S. Chatterjee   +4 more
doaj   +4 more sources

Identification of host genetic factors modulating β-lactam resistance in Escherichia coli harbouring plasmid-borne β-lactamase through transposon-sequencing [PDF]

Emerging Microbes and Infections
Since β-lactam antibiotics are widely used, emergence of bacteria with resistance to them poses a significant threat to society. In particular, acquisition of genes encoding β-lactamase, an enzyme that degrades β-lactam antibiotics, has been a major ...
Hyunhee Kim, Travis Bell, Kihyun Lee, Jeongyun Jeong, James C. A. Bardwell, Changhan Lee   +5 more
doaj   +4 more sources

Molecular Determinants of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus (MRSA): An Updated Review [PDF]

Antibiotics, 2023
The development of antibiotic resistance in Staphylococcus aureus, particularly in methicillin-resistant S. aureus (MRSA), has become a significant health concern worldwide.
Harshad Lade, Jae-Seok Kim
doaj   +2 more sources

Detection of β-lactam resistance genes in Gram-negative bacteria from positive blood cultures using a microchip-based molecular assay [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundAccurate detection of β-lactam resistance genes in bloodstream infections is critical for guiding antimicrobial therapy. This study evaluates the Alifax Gram-negative resistance (GNR) microchip assay for detecting β-lactam resistance genes ...
Vittorio Ivagnes, Flavio De Maio, Ilaria Baccani, Alberto Antonelli, Giulia Menchinelli, Roberto Rosato, Giordana Cafaro, Giulia Santarelli, Federico Falletta, Tiziana D’Inzeo, Tiziana D’Inzeo, Maurizio Sanguinetti, Maurizio Sanguinetti, Teresa Spanu, Giulia De Angelis, Giulia De Angelis, Gian Maria Rossolini, Gian Maria Rossolini, Brunella Posteraro, Brunella Posteraro   +19 more
doaj   +2 more sources

Exploration of the role of the penicillin binding protein 2c (Pbp2c) in inducible β-lactam resistance in Corynebacteriaceae [PDF]

Frontiers in Microbiology
Six genes encoding putative high molecular weight penicillin-binding proteins (Pbp) are present in the genome of the β-lactam-resistant strain Corynebacterium jeikeium K411.
Marie Lavollay, Marie Lavollay, Marie Lavollay, Céline Buon, Vincent Le Moigne, Fabrice Compain, Armel Guyonvarch, Matthieu Fonvielle   +7 more
doaj   +2 more sources

Interspecies recombination, not de novo mutation, maintains virulence after β-lactam resistance acquisition in Streptococcus pneumoniae [PDF]

Cell Reports, 2022
Andrew T Nishimoto, Juan C Ortiz-Marquez, Haley Echlin   +2 more
exaly   +2 more sources

β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward

Frontiers in Microbiology, 2023
β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial agents for treating both Gram-negative and Gram-positive bacterial infections.
Lekshmi Narendrakumar, Medha Chakraborty, Shashi Kumari, Deepjyoti Paul, Bhabatosh Das   +4 more
doaj   +1 more source

Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics

mBio, 2023
The purine-derived signaling molecules c-di-AMP and (p)ppGpp control mecA/PBP2a-mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise the possibility that purine availability can control antibiotic susceptibility ...
Aaron C. Nolan, Merve S. Zeden, Igor Kviatkovski, Christopher Campbell, Lucy Urwin, Rebecca M. Corrigan, Angelika Gründling, James P. O’Gara   +7 more
doaj   +1 more source

Detection of an IS21 insertion sequence in the mexR gene of Pseudomonas aeruginosa increasing β-lactam resistance [PDF]

FEMS Microbiology Letters, 2004
To understand the regulation of the MexAB OprM efflux system in a clinical strain of Pseudomonas aeruginosa presenting a decreased susceptibility to ticarcillin and aztreonam, the mexR repressor gene was amplified by polymerase chain reaction (PCR) and was shown to be disrupted by an insertion sequence of more than 2 kb, with characteristic direct and ...
Boutoille, David, Corvec, Stéphane, Caroff, Nathalie, Giraudeau, Cécile, Espaze, Eric, Caillon, Jocelyne, Plesiat, Patrick, Reynaud, Alain   +7 more
openaire   +2 more sources

Decreased membrane permeability in a polymyxin B-resistantEscherichia colimutant exhibiting multiple resistance to β-lactams as well as aminoglycosides [PDF]

FEMS Microbiology Letters, 1998
A laboratory mutant of Escherichia coli stably resistant to more than 36,000 U ml-1 of polymyxin B was isolated. The mutant exhibited moderate increases in minimum inhibitory concentration to fluoroquinolones and bacitracin but high levels of cross-resistance to beta-lactams and aminoglycosides.
S O, Rahaman, J, Mukherjee, A, Chakrabarti, S, Pal   +3 more
openaire   +2 more sources