Results 21 to 30 of about 45,473 (217)
A Clinical Extensively-Drug Resistant (XDR) Escherichia coli and Role of Its β-Lactamase Genes
Frontiers in Microbiology, 2020 An extensively-drug resistant (XDR) Escherichia coli W60 was isolated from the urine sample of a patient. The genetic basis for its XDR phenotype was investigated, particularly the basis for its resistance toward β-lactam/BLI (β-Lactamase Inhibitor ...
Mingyu Wang +10 more
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Antibiotic Resistance in Pseudomonas Aeruginosa is Associated with Decreased Fitness
Cellular Physiology and Biochemistry, 2013 The number of clinical specimens containing β-lactam-resistant Pseudomonas aeruginosa isolates is increasing. However, whether resistance is associated with reduced fitness is still uncertain in clinical Pseudomonas aeruginosa isolates. In this study, we
Zhenzhen Sun +6 more
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Microbiology Spectrum, 2023 New strategies are urgently needed to address the public health threat of antimicrobial resistance. Synergistic agent combinations provide one possible pathway toward addressing this need and are also of fundamental mechanistic interest.
Amar Deep Sharma, William G. Gutheil
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Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus
Antibiotics, 2022 Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful human pathogens with the potential to cause significant morbidity and mortality.
Harshad Lade +2 more
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Intrinsic Class D β-Lactamases of
mBio, 2018 Clostridium difficile is the causative agent of the deadly C. difficile infection. Resistance of the pathogen to β-lactam antibiotics plays a major role in the development of the disease, but the mechanism of resistance is currently unknown.
Marta Toth +3 more
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Restricted Sequence Variation in
mSphere, 2020 A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding protein (PBP) PBP2x. To determine whether this is an isolated case or reflects a broader prevalence of mutations that might ...
Andrew Hayes +4 more
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Folia Histochemica et Cytobiologica, 2011 Extended spectrum β-lactamases production is one of the most common mechanism of resistance to extended spectrum β-lactam antibiotics is increasing worldwide. Twenty five strains of Klebsiella pneumoniae isolated from clinical specimens were tested. Based on the phenotypic confirmatory test all these strains were defined as ESBL producers named ESBL(+).
Małgorzata Krawczyk +8 more
openaire +5 more sources
Microbiology Spectrum, 2022 Vancomycin and β-lactams are clinically important antibiotics that inhibit the formation of peptidoglycan cross-links, but their binding targets are different.
Si Hyoung Park +5 more
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mBio, 2022 In Bacillus thuringiensis, β-lactam antibiotic resistance is controlled by the extracytoplasmic function (ECF) σ factor σP. σP activity is inhibited by the anti-σ factor RsiP. In the presence of β-lactam antibiotics, RsiP is degraded and σP is activated.
Kelsie M. Nauta +2 more
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Synthetic Lethality Reveals Mechanisms of
mBio, 2014 Most β-lactam antibiotics are ineffective against Mycobacterium tuberculosis due to the microbe’s innate resistance. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has prompted interest to repurpose this class of ...
Shichun Lun +7 more
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