Results 41 to 50 of about 86,850 (260)

Novel determinants of antibiotic resistance : identification of mutated loci in highly methicillin-resistant subpopulations of methicillin-resistant Staphylococcus aureus

, 2014
This work was supported by a grant from the U.S. Public Health Service 2 RO1 AI457838-14 and by grant UL1 TR000043-07S1 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) Clinical and Translational ...
Kim, Choonkeun, Hermínia de Lencastre, Matthew T. J. Holden, Holden, Matthew T J, María Pardos de la Gándara, Tomasz, Alexander, Parkhill, Julian, de Lencastre, Hermínia, Alexander Tomasz, Stephen D. Bentley, Janina Dordel, Dordel, Janina, Pardos de la Gándara, María, Chung, Marilyn, Bentley, Stephen D, Marilyn Chung, Choonkeun Kim, Julian Parkhill   +17 more
core   +1 more source

Antibiotic resistance in the environment, with particular reference to MRSA [PDF]

, 2008
The introduction of β-lactam antibiotics (penicillins and cephalosporins) in the 1940s and 1950s probably represents the most dramatic event in the battle against infection in human medicine.
William Gaze, Gaze, William H., Hawkey, Peter, Peter Hawkey, Hawkey, P. M., O'Neill, Colette, O'Neill, C, Colette O'Neill, Elizabeth Wellington, Gaze, W, Wellington, E, Wellington, Elizabeth, Wellington, E. M. H., Gaze, William   +13 more
core   +1 more source

Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci. [PDF]

, 2017
The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA-an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams.
Sobral, R, Jesper Boye Nielsen, Joana Rolo, Tomasz, A, Worning, Peder, Tomasz, Alexander, Miragaia, M, Alexander Tomasz, Westh, H, Worning, P, Ons Bouchami, Hughes, D, Vincent Perreten, Miragaia, Maria, Bouchami, Ons, Perreten, Vincent, Peter Damborg, De Lencastre, H, Rory Bowden, Bowden, Rory, Hermínia de Lencastre, Sobral, Rita, Bowden, R, Boye Nielsen, Jesper, Damborg, Peter, Bouchami, O, de Lencastre, Hermínia, Nielsen, J B, Perreten, V, Peder Worning, Rolo, Joana, Guardabassi, Luca, Guardabassi, L, Damborg, P, Maria Miragaia, Westh, Henrik, Rita Sobral, Luca Guardabassi, Rolo, J, Boye Nielsen, J, Henrik Westh   +40 more
core   +1 more source

Penicillin-Binding Proteins, β-Lactamases, and β-Lactamase Inhibitors in β-Lactam-Producing Actinobacteria: Self-Resistance Mechanisms

, 2022
The human society faces a serious problem due to the widespread resistance to antibiotics in clinical practice. Most antibiotic biosynthesis gene clusters in actinobacteria contain genes for intrinsic self-resistance to the produced antibiotics, and it ...
Martin, Juan F., Paloma Liras, Liras, Paloma, Juan F. Martin, Alvarez-Alvarez, Ruben, Ruben Alvarez-Alvarez   +5 more
core   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Penicillin-Binding Protein Transpeptidase Signatures for Tracking and Predicting β-Lactam Resistance Levels in Streptococcus pneumoniae

mBio, 2016
β-Lactam antibiotics are the drugs of choice to treat pneumococcal infections. The spread of β-lactam-resistant pneumococci is a major concern in choosing an effective therapy for patients.
Yuan Li, Benjamin J. Metcalf, Sopio Chochua, Zhongya Li, Robert E. Gertz, Hollis Walker, Paulina A. Hawkins, Theresa Tran, Cynthia G. Whitney, Lesley McGee, Bernard W. Beall   +10 more
doaj   +1 more source

Molecular targets of β-Lactam-based antimicrobials : Beyond the usual suspects : Beyond the usual suspects

, 2018
The common practice in antibacterial drug development has been to rapidly make an attempt to find ever-more stable and broad-spectrum variants for a particular antibiotic, once a drug resistance for that antibiotic is detected.
Monika Konaklieva (16750224)
core   +1 more source

The bla and mec families of β-lactam resistance genes in the genera Macrococcus, Mammaliicoccus and Staphylococcus: an in-depth analysis with emphasis on Macrococcus.

, 2022
β-Lactamases (Bla) and low-affinity penicillin-binding proteins (PBP2A) are responsible for β-lactam resistance in the genera Macrococcus, Mammaliicoccus and Staphylococcus.
Schwendener, Sybille, Perreten, Vincent
core   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source