Results 41 to 50 of about 74,609 (245)

Synthetic Lethality Reveals Mechanisms of Mycobacterium tuberculosis Resistance to β-Lactams

mBio, 2014
Most β-lactam antibiotics are ineffective against Mycobacterium tuberculosis due to the microbe’s innate resistance. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has prompted interest to repurpose this class of ...
Shichun Lun, David Miranda, Andre Kubler, Haidan Guo, Mariama C. Maiga, Kathryn Winglee, Shaaretha Pelly, William R. Bishai   +7 more
doaj   +1 more source

Rapid optical determination of β-lactamase and antibiotic activity [PDF]

, 2014
Background: The absence of rapid tests evaluating antibiotic susceptibility results in the empirical prescription of antibiotics. This can lead to treatment failures due to escalating antibiotic resistance, and also furthers the emergence of drug ...
Hasan, Tayyaba, Khan, Shazia, Nau, Gerard J, Sallum, Ulysses W, Zheng, Xiang   +4 more
core   +1 more source

Elevating NagZ Improves Resistance to β-Lactam Antibiotics via Promoting AmpC β-Lactamase in Enterobacter cloacae

Frontiers in Microbiology, 2020
Enterobacter cloacae complex (ECC), one of the most common opportunistic pathogens causing multiple infections in human, is resistant to β-lactam antibiotics mainly due to its highly expressed chromosomal AmpC β-lactamase.
Xianggui Yang, Jun Zeng, Qin Zhou, Xuejing Yu, Yuanxiu Zhong, Fuying Wang, Hongfei Du, Fang Nie, Xueli Pang, Dan Wang, Yingzi Fan, Tingting Bai, Ying Xu   +12 more
doaj   +1 more source

Live to cheat another day: bacterial dormancy facilitates the social exploitation of beta-lactamases [PDF]

, 2015
The breakdown of antibiotics by β-lactamases may be cooperative, since resistant cells can detoxify their environment and facilitate the growth of susceptible neighbours. However, previous studies of this phenomenon have used artificial bacterial vectors
A Bloor, A Brooun, A Ross-Gillespie, A Ross-Gillespie, AS Hackman, B Raymond, B Raymond, Ben Raymond, BR Levin, C Dahlberg, D Clark, DA Mitchison, DM Livermore, E Tuomanen, EA Yurtsev, Frances Medaney, G Rolinson, GL Hobby, HC Neu, I Brook, I Brook, JJ Harrison, JL Cottell, JW Bigger, K Datsenko, K Lewis, K Lewis, K Lewis, K Sandoz, L Dugatkin, L Zhou, M Doebeli, M Ghoul, MH Perlin, NQ Balaban, O Ciofu, PS Stewart, R Ellis, R Lenski, R Lenski, R Tacking, Richard J Ellis, RJ Worthington, RM Cozens, RN Jones, S Brown, SA West, SA West, SP Brown, SP Diggle, Tatiana Dimitriu, X-X Zhang, XX Zhang   +52 more
core   +1 more source

Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics

Nature Communications, 2023
Antibiotic resistance of bacteria is considered one of the most alarming developments in modern medicine. While varied pathways for bacteria acquiring antibiotic resistance have been identified, there still are open questions concerning the mechanisms ...
Elad Arad, Kasper B. Pedersen, Orit Malka, Sisira Mambram Kunnath, Nimrod Golan, Polina Aibinder, Birgit Schiøtt, Hanna Rapaport, Meytal Landau, Raz Jelinek   +9 more
doaj   +1 more source

Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina [PDF]

, 2014
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) emerged at the Pediatric Hospital of Misiones Province, north Argentina, in 2003 as a cause of community-acquired (CA) infections, mostly associated with skin and soft tissue infections ...
Gardella, Noella Mariel, Grenon, Sandra Liliana, Gutkind, Gabriel Osvaldo, Mollerach, Marta Eugenia, Ubeda, Clotilde, Von Specht, Martha Helena   +5 more
core   +1 more source

Important role of a putative lytic transglycosylase Cj0843c in β-lactam resistance in Campylobacter jejuni

Frontiers in Microbiology, 2015
Beta-lactam antibiotics are an important class of antibiotics for treating bacterial infections. Despite prevalent β-lactam resistance in Campylobacter jejuni, the leading bacterial cause of human diarrhea in developed countries, molecular mechanism of β-
Ximin eZeng, Barbara eGillespie, Jun eLin   +2 more
doaj   +1 more source

Molecular basis of β-lactam antibiotic resistance of ESKAPE bacterium E. faecium Penicillin Binding Protein PBP5

Nature Communications, 2023
Penicillin-binding proteins (PBPs) are essential for the formation of the bacterial cell wall. They are also the targets of β-lactam antibiotics. In Enterococcus faecium, high levels of resistance to β-lactams are associated with the expression of PBP5 ...
Yamanappa Hunashal, Ganesan Senthil Kumar, Meng S. Choy, Éverton D. D’Andréa, Andre Da Silva Santiago, Marta V. Schoenle, Charlene Desbonnet, Michel Arthur, Louis B. Rice, Rebecca Page, Wolfgang Peti   +10 more
doaj   +1 more source

RelQ Mediates the Expression of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus

Frontiers in Microbiology, 2019
An induced stringent response, which is established by an increased level of (p)ppGpp, is required for the expression of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA).
Ajita Bhawini, Parul Pandey, Ashutosh Prakash Dubey, Aafreen Zehra, Gopal Nath, Mukti Nath Mishra, Mukti Nath Mishra   +6 more
doaj   +1 more source

The Distribution of ESBL-Producing Enterobacteriaceae: Leicestershire UK Compared to Worldwide [PDF]

, 2019
open access ...
Reid, R., Samarasinghe, S., Varnakulasingam, Atheena   +2 more
core   +1 more source