Results 31 to 40 of about 86,850 (260)
Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus
Antibiotics, 2022 Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful human pathogens with the potential to cause significant morbidity and mortality.
Harshad Lade +2 more
doaj +1 more source
Intrinsic Class D β-Lactamases of
mBio, 2018 Clostridium difficile is the causative agent of the deadly C. difficile infection. Resistance of the pathogen to β-lactam antibiotics plays a major role in the development of the disease, but the mechanism of resistance is currently unknown.
Marta Toth +3 more
doaj +1 more source
Restricted Sequence Variation in
mSphere, 2020 A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding protein (PBP) PBP2x. To determine whether this is an isolated case or reflects a broader prevalence of mutations that might ...
Andrew Hayes +4 more
doaj +1 more source
Folia Histochemica et Cytobiologica, 2011 Extended spectrum β-lactamases production is one of the most common mechanism of resistance to extended spectrum β-lactam antibiotics is increasing worldwide. Twenty five strains of Klebsiella pneumoniae isolated from clinical specimens were tested. Based on the phenotypic confirmatory test all these strains were defined as ESBL producers named ESBL(+).
Małgorzata Krawczyk +8 more
openaire +5 more sources
Microbiology Spectrum, 2022 Vancomycin and β-lactams are clinically important antibiotics that inhibit the formation of peptidoglycan cross-links, but their binding targets are different.
Si Hyoung Park +5 more
doaj +1 more source
mBio, 2022 In Bacillus thuringiensis, β-lactam antibiotic resistance is controlled by the extracytoplasmic function (ECF) σ factor σP. σP activity is inhibited by the anti-σ factor RsiP. In the presence of β-lactam antibiotics, RsiP is degraded and σP is activated.
Kelsie M. Nauta +2 more
doaj +1 more source
Synthetic Lethality Reveals Mechanisms of
mBio, 2014 Most β-lactam antibiotics are ineffective against Mycobacterium tuberculosis due to the microbe’s innate resistance. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has prompted interest to repurpose this class of ...
Shichun Lun +7 more
doaj +1 more source
Frontiers in Microbiology, 2020 Enterobacter cloacae complex (ECC), one of the most common opportunistic pathogens causing multiple infections in human, is resistant to β-lactam antibiotics mainly due to its highly expressed chromosomal AmpC β-lactamase.
Xianggui Yang +12 more
doaj +1 more source
Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics
Nature Communications, 2023 Antibiotic resistance of bacteria is considered one of the most alarming developments in modern medicine. While varied pathways for bacteria acquiring antibiotic resistance have been identified, there still are open questions concerning the mechanisms ...
Elad Arad +9 more
doaj +1 more source
PBP4 activity and its overexpression are necessary for PBP4-mediated high-level β-lactam resistance [PDF]
, 2018 Background:PBP4 is typically considered unimportant for conferring high-level β-lactam resistance in Staphylococcus aureus. Mutations in PBP4 have been associated with β-lactam non-susceptibility among natural strains of S. aureus.
Pinho, Mariana G +13 more
core +1 more source