Results 141 to 150 of about 144,498 (294)

Reusing health records from farm animal practices at scale: A potential complementary method of surveillance

Veterinary Record, EarlyView.
Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins, Peers Davies, Peter‐John Noble, Anna Bunford‐Davies, April Lawson, Gina Pinchbeck, Ifan Lloyd, Robert Smith, Alan D. Radford   +8 more
wiley   +1 more source

Antibacterial Activity of Culture Extracts of Penicillium chrysogenum PCL501: Effects of Carbon Sources [PDF]

, 2009
Penicillium chrysogenum PCL501 produced β-lactam antibiotics when fermented with different agro-wastes: cassava shavings, corncob, sawdust and sugarcane pulp.
Chinedu, SN, Okafor, UA, Okochi, VI, Onyegeme-Okerenta, BM   +3 more
core   +1 more source

Proteomics as the final step in the functional metagenomics study of antimicrobial resistance [PDF]

, 2015
peer-reviewedThe majority of clinically applied antimicrobial agents are derived from natural products generated by soil microorganisms and therefore resistance is likely to be ubiquitous in such environments.
Cotter, Paul D., Fouhy, Fiona, Hill, Colin, STANTON, CATHERINE, Walsh, Fiona   +4 more
core   +1 more source

Overexpression of Escherichia coli yaiX Confers Multidrug Resistance and Enhances Virulence in the Silkworm Infection Model

Microbiology and Immunology, EarlyView.
ABSTRACT The emergence of bacteria with both antimicrobial resistance and high virulence has become a global health concern, underscoring the urgent need to elucidate the molecular basis underlying these traits. Here, we employed the silkworm (Bombyx mori) infection model, which is suitable for high‐throughput screening, together with an Escherichia ...
Kinuka Hongu, Kazuya Ishikawa, Tomoki Kosaki, Shin‐Ichi Miyoshi, Kazuyuki Furuta, Chikara Kaito   +5 more
wiley   +1 more source

Ampicillin promotes the biofilm formation of Shewanella putrefaciens through the c-di-GMP-regulated BpfAGD system

Microbiology Spectrum
Although many Shewanella strains are naturally resistant to some β-lactam antibiotics, research into the effect of these antibiotics on Shewanella biofilm formation is scarce.
Rui Shi, Di Sun, Jiawen Liu, Jing Yang, Jingrong Zhu, Cong Liu, Weijie Liu   +6 more
doaj   +1 more source

Binding and processing of β‐lactam antibiotics by the transpeptidase LdtMt2 from Mycobacterium tuberculosis

The FEBS Journal, 2017
β‐lactam antibiotics represent a novel direction in the chemotherapy of tuberculosis that brings the peptidoglycan layer of the complex mycobacterial cell wall in focus as a therapeutic target.
E. Steiner, G. Schneider, R. Schnell
semanticscholar   +1 more source

Evolution of Drug Resistance: Insight on TEM β-Lactamases Structure and Activity and β-Lactam Antibiotics [PDF]

, 2014
Since the discovery of the first penicillin bacterial resistance to β-lactam antibiotics has spread and evolved promoting new resistances to pathogens.
Fernandes, Rúben, Moreira, I. S., Pimenta, A. C.   +2 more
core   +1 more source

Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy

Allergy, EarlyView.
DeAns with defined nanoscale structure reveal that conjugate size and determinant density govern IgE‐mediated effector‐cell activation in AX allergy. All DeAn generations bind to sIgE in inhibition immunoassay, but only larger DeAns trigger FcεRI‐dependent responses in mouse MC, huRBL‐2H3, and LUVA cells.
Amene Tesfaye Ayane, Maria Salas, Sara Benede, Maria J. Rodriguez‐Sanchez, Maria J. Rodriguez‐Sojo, Isabel M. Jiménez‐Sánchez, Gador Bogas, Ezequiel Perez‐Inestrosa, Cristobalina Mayorga, Juan L. Paris, Alba Rodríguez‐Nogales, María J. Torres, María I. Montañez   +12 more
wiley   +1 more source

New β-Lactam/β-Lactamase Inhibitor Combination Antibiotics

Pathogens
The growing problem of infections due to pathogens with antimicrobial resistance, especially Gram-negative bacteria, has led to the development of new β-lactam/β-lactamase inhibitor combination antibiotics.
Maria Sargianou, Panagiotis Stathopoulos, Christos Vrysis, Iva D. Tzvetanova, Matthew E. Falagas   +4 more
doaj   +1 more source

Prolonged administration of β-lactam antibiotics – a comprehensive review and critical appraisal

Swiss Medical Weekly, 2016
Prolonged infusion of β-lactam antibiotics as either extended (over at least 2 hours) or continuous infusion is increasingly applied in intensive care units around the world in an attempt to optimise treatment with this most commonly used class of ...
Michael Osthoff, Martin Siegemund, Gianmarco Balestra, Mohd Hafiz Abdul-Aziz, Jason A Roberts   +4 more
doaj   +1 more source