Results 121 to 130 of about 935,518 (288)

Human metallo-β-lactamase enzymes degrade penicillin

Scientific Reports, 2019
Nonribosomal peptides are assemblages, including antibiotics, of canonical amino acids and other molecules. β-lactam antibiotics act on bacterial cell walls and can be cleaved by β-lactamases.
Seydina M. Diene, Lucile Pinault, Vivek Keshri, Nicholas Armstrong, Saber Khelaifia, Eric Chabrière, Gustavo Caetano-Anolles, Philippe Colson, Bernard La Scola, Jean-Marc Rolain, Pierre Pontarotti, Didier Raoult   +11 more
doaj   +1 more source

Detection of zoonotic bacteria in wild Australian freshwater turtles

Australian Veterinary Journal, EarlyView.
Freshwater turtles are long‐lived, abundant components of Australian aquatic ecosystems, yet little is known about the diversity and prevalence of zoonotic bacteria they may carry. In this study, we conducted one of the most comprehensive surveys to date of zoonotic microorganisms associated with wild Australian freshwater turtles.
TF Scheelings, TTH Van, RJ Moore, LF Skerratt   +3 more
wiley   +1 more source

Phenotypic Characterization and Antibiotic Resistance Patterns of Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-Producing Gram-Negative Bacteria in a Referral Hospital, Saudi Arabia

Canadian Journal of Infectious Diseases and Medical Microbiology, 2019
Background. Emergence of pathogenic bacteria carrying β-lactamase-resistant determinants has become a major health problem in the hospital setting. The study aimed to determine antibiotic-resistant patterns and frequency of extended-spectrum β-lactamase-
Mutasim E. Ibrahim, Mohammed Abbas, Abdullah M. Al-Shahrai, Bahaeldin K. Elamin   +3 more
doaj   +1 more source

Analysing diversity among β-lactamase encoding genes in aquatic environments [PDF]

FEMS Microbiology Ecology, 2006
Isabel Henriques, Alexandra Moura, Artur Alves, Maria José Saavedra, António Correia   +4 more
openaire   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

A retrospective analysis of bacterial pathogens in wounds in an equine hospital (2017–2022)

Equine Veterinary Education, EarlyView.
Summary Background Bacterial infections are a major cause of morbidity in horses, particularly in soft tissue wounds (STW) and surgical site infections (SSI). Rising antimicrobial resistance poses challenges for timely treatment. Knowledge of common pathogens and their resistance patterns is therefore essential.
J. Nebes, M. Schneeberger, S. Schmitt, J. N. van Spijk   +3 more
wiley   +1 more source

Can Artificial Intelligence Be Utilised to Develop Point‐of‐Care Endodontic Microbiological Technologies?

International Endodontic Journal, EarlyView.
ABSTRACT Background Primary or persistent endodontic disease is caused by microbial biofilms that irritate the pulp and periapical tissues. Extensive microbiological analyses of these biofilms and their constituent pathogens have revealed their diversity and complexity.
Ashraf F. Fouad
wiley   +1 more source

Two different β-lactamase genes are present inStreptomycees cacaoi [PDF]

FEMS Microbiology Letters, 1992
Juana Magdalena, Mats Forsman, Mauro V. Lenzini, Alain Brans, Jean Dusart   +4 more
openaire   +1 more source

MOESM2 of Investigation of urban birds as source of β-lactamase-producing Gram-negative bacteria in Marseille city, France

, 2019
Additional file 2. Sampling details according to the investigated locations.
Ngaiganam, Edgarthe, Pagnier, Isabelle, Chaalal, Wafaa, Leangapichart, Thongpan, Chabou, Selma, Rolain, Jean-Marc, Diene, Seydina   +6 more
openaire   +1 more source

Resistance of Gram-Negative Bacteria to Cefepime-Enmetazobactam: A Systematic Review

Pathogens
Cefepime-enmetazobactam is a novel β-lactam/β-lactamase inhibitor combination showing good activity against multidrug-resistant (MDR) Gram-negative bacteria producing a variety of β-lactamases.
Matthew E. Falagas, Laura T. Romanos, Dimitrios S. Kontogiannis, Katerina Tsiara, Stylianos A. Kakoullis   +4 more
doaj   +1 more source