Results 101 to 110 of about 935,518 (288)

Salicylate decreases production of AmpC type β-lactamases and increases susceptibility to β-lactams in aMorganella morganiiclinical isolate [PDF]

FEMS Microbiology Letters, 2004
The effect of salicylate, a marRAB inducer, on the resistance to β-lactams was characterized in an AmpC β-lactamase hyperproducer Morganella morganii clinical isolate (the M1 strain). Results were compared with those of the effect of salicylate in a wild-type M. morganii strain.
María M. Tavío, Mariagrazia Perilli, Jordi Vila, Pino Becerro, Lucía Casañas, Gianfranco Amicosante, María Teresa Jiménez de Anta   +6 more
openaire   +1 more source

Sodium deoxycholate synergistically enhances the antimicrobial activity of β-lactam antibiotics againstβ-lactamase-producing Staphylococcus aureus [PDF]

, 2012
Background β-lactamase-producing Staphylococcus aureus synthesizes a β-lactamase which decomposes the β-lactam ring, and consequently almost all β-lactam antibiotics are inactivated by the enzyme. The appearance of β-lactamase-producing bacterial strains
Yamada, Akira, Yoshida, Sayuri, Yaegashi, Asaka, Fujii, Yuichi, Hirano, Kano, Nozawa, Koohei, Tanaka, Satomi, Yamaki, Fumiko, Horie, Hitoshi   +8 more
core  

Metagenomic and culture‐based insights into host and plasmid contexts of high‐risk ARGs in poultry farm environments

iMetaOmics, EarlyView.
Shotgun metagenomics and culture‐based isolate genomics revealed position‐associated high‐risk antibiotic resistance genes (ARGs) signals across poultry manure piles and surrounding soils. Culture‐confirmed Enterobacteriaceae and IncHI2A‐related blaNDM‐5 plasmid backgrounds further highlight priority host‐ARG‐plasmid contexts for farm antimicrobial ...
Yaling Wang, Lianwei Ye, Linan He, Zhenlong Wu, Yiwen Yang, Sheng Chen   +5 more
wiley   +1 more source

Evaluation of Ceftriaxone as a Monotherapy and Amoxicillin With Clavulanic Acid as Combination Therapy in Surgical Prophylaxis

iNew Medicine, EarlyView.
ABSTRACT Surgical antibiotic prophylaxis (SAP) is crucial in preventing postoperative surgical site infections (SSIs), especially in clean and clean‐contaminated surgeries. It was a prospective comparative observational study that compared the effectiveness and safety of single‐dose ceftriaxone monotherapy with amoxicillin–clavulanic acid as a ...
Anayat Ullah, Arsh Ali, Md Nematullah, Suriya Kumar Singh, Anant Singh Paliwal, Najish Parveen   +5 more
wiley   +1 more source

A multicenter study of β-lactamase-producing Klebsiella pneumoniae isolated from university teaching hospitals of Urmia, Iran

Journal of Infection in Developing Countries, 2019
Introduction: Klebsiella pneumoniae is an opportunistic pathogen accounting for 5-7% of hospital acquired infections. The emergence of carbapenem-resistant Klebsiella pneumoniae has been increasing rapidly over recent years causing many therapeutic ...
Narges Darabi, Morteza Motazakker, Hamid Reza Khalkhali, Saber Yousefi   +3 more
doaj   +1 more source

Prevalence of multiresistant gram-negative organisms in a tertiary hospital in Mwanza, Tanzania. [PDF]

, 2009
\ud Antimicrobial resistance is fast becoming a global concern with rapid increases in multidrug-resistant Gram negative organisms. The prevalence of extended spectrum beta-lactamase (ESBL)-producing clinical isolates increases the burden on implementing
Kamugisha, Erasmus, Chakraborty Trinad, Mirambo Mariam, Mshana, S.E., Mirambo, M., Stephen E Mshana, Mariam Mirambo, Kamugisha Erasmus, Erasmus Kamugisha, Mshana Stephen E, Lyamuya Eligius F, Mirambo, Mariam, Lyamuya, Eligius F, Eligius F Lyamuya, Chakraborty, T., Chakraborty, Trinad, Lyamuya, E.F., Mshana, Stephen E, Kamugisha, E., Trinad Chakraborty   +19 more
core   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Functional insights into Streptomyces isolates containing both clavulanic acid-like and carbapenem biosynthetic gene clusters

mSphere
β-Lactam antibiotics and β-lactamase inhibitor combinations are essential for combating antimicrobial resistance, with many β-lactams, including clavulanic acid (CA), themselves being products of specialized metabolic pathways in bacteria. CA is a potent
Kapil Tahlan, Arshad Ali Shaikh, Jingyu Liu, Kajal Gupta, Nader AbuSara, Santosh Kumar Srivastava, Adau Deng, Ayla Rouah, Madelyn Joan Swackhamer   +8 more
doaj   +1 more source

Filtration‐Based SERS With In Situ Gold Growth in Bacterial Microenvironment for Rapid Detection of Low‐Level Bacteria

Small Methods, EarlyView.
A filtration‐assisted SERS platform integrating in situ gold growth within the bacterial microenvironment enables rapid and highly sensitive detection of low‐level bacteria in complex biological matrices. By overcoming hotspot–bacteria mismatch, the platform simultaneously achieves selective bacterial identification and rapid antimicrobial ...
Eun‐Bi Jang, Ji Young Lee, Hoeil Chung, Min‐Young Lee   +3 more
wiley   +1 more source

Isolation of carbapenem‐resistant Pseudomonas aeruginosa and other Gram‐negative ESKAPE organisms from samples of raw‐meat diets for dogs in the UK

Veterinary Record, EarlyView.
Abstract Background Gram‐negative ESKAPE organisms are an emerging threat in veterinary medicine that also have zoonotic potential. However, little is known about the prevalence and risks of these organisms in pet food. We present the incidental finding of gram‐negative ESKAPE organisms within samples of raw meat diets for dogs in the United Kingdom ...
Genever Morgan, Nicola Williams, Jenny Llewelyn, Sam Haldenby, Gina Pinchbeck, Dorina Timofte   +5 more
wiley   +1 more source