Results 81 to 90 of about 935,518 (288)

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors

Antibiotics, 2023
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors to counter this
Nakita Reddy, Letisha Girdhari, Mbongeni Shungube, Arnoldus C. Gouws, Byron K. Peters, Kamal K. Rajbongshi, Sooraj Baijnath, Sipho Mdanda, Thandokuhle Ntombela, Thilona Arumugam, Linda A. Bester, Sanil D. Singh, Anil Chuturgoon, Per I. Arvidsson, Glenn E. M Maguire, Hendrik G. Kruger, Thavendran Govender, Tricia Naicker   +17 more
doaj   +1 more source

Penetration of β-lactamase inhibitors into the periplasm of Gram-negative bacteria [PDF]

FEMS Microbiology Letters, 1999
The effectiveness of a beta-lactamase inhibitor/beta-lactam combination against Gram-negative pathogens depends on many interplaying factors, one of which is the penetration of the inhibitor across the outer membrane. In this work we have measured the relative penetrations of clavulanic acid, sulbactam, tazobactam and BRL 42715 into two strains of ...
Farmer TH, Degnan BA, Payne DJ
openaire   +3 more sources

Table_4_Increased zinc levels facilitate phenotypic detection of ceftazidime-avibactam resistance in metallo-β-lactamase-producing Gram-negative bacteria.docx

, 2022
Ceftazidime-avibactam is one of the last resort antimicrobial agents for the treatment of carbapenem-resistant, Gram-negative bacteria. Metallo-β-lactamase-producing bacteria are considered to be ceftazidime-avibactam resistant. Here, we evaluated a semi-
Niels Pfennigwerth (5244080), Andreas Hiergeist (3470183), Tamara Rügamer (14155239), Axel Hamprecht (605845), Yvonne Pfeifer (457305), Sören G. Gatermann (12050073), André Gessner (821452), Michaela Simon (6587036), Roman G. Gerlach (7388399), Agnes Schröder (458932), Jonathan Jantsch (458934)   +10 more
core   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

EXTENDED SPECTRUM Β- LACTAMASE PRODUCING SHIGELLA FLEXNERIA CASE REPORT

Pakistan Armed Forces Medical Journal, 2016
Infection by Shigella species is one of the major cause of morbidity especially in children with diarrhea. Extended spectrum β lactamases (ESBL) confer resistance to most of the beta-lactam antibiotics, including penicillins, cephalosporins and ...
Mehreen Gilani, Tehmina MunirMunir, Mahwish Latif, Amira Haroon, Sabahat Rehman   +4 more
doaj   +2 more sources

Characterization of Piperacillin/Tazobactam-Resistant Klebsiella oxytoca Recovered from a Nosocomial Outbreak. [PDF]

PLoS ONE, 2015
We characterized 12 clinical isolates of Klebsiella oxytoca with the extended-spectrum β-lactamase (ESBL) phenotype (high minimum inhibitory concentration [MIC] values of ceftriaxone) recovered over 9 months at a university hospital in Japan.
Ai Fujita, Kouji Kimura, Satoru Yokoyama, Wanchun Jin, Jun-Ichi Wachino, Keiko Yamada, Hiroyuki Suematsu, Yuka Yamagishi, Hiroshige Mikamo, Yoshichika Arakawa   +9 more
doaj   +1 more source

Detection of inducible β-lactamase by an agar dilution technique [PDF]

FEMS Microbiology Letters, 1985
An agar dilution technique for the detection of inducible β-lactamase-mediated resistance to the newer cephalosporins is described. Cefoxitin (16 μg/ml) was incorporated in agar plates together with cefamandole (8 μg/ml) or cefotaxime (8 μg/ml). The susceptibility of 35 strains of Enterobacter cloacae to these combinations was compared with their ...
openaire   +1 more source

Cefotaxime-hydrolysing activity of the β-lactamase ofKlebsiella oxytocaD488 could be related to a threonine residue at position 140 [PDF]

FEMS Microbiology Letters, 1991
The chromosomally encoded β-lactamase of Klebsiella oxytoca D483 strain, active against all third-generation cephalosporins but ceftazidime, was purified to homogeneity. The pure protein was digested by trypsin, Staphylococcus aureus V8 protease or proteinase Asp-N.
Alain Reynaud, Jean Péduzzi, Michel Barthélémy, Roger Labia   +3 more
openaire   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source