Results 171 to 180 of about 762,836 (292)

Structure-Based Approach for Binding Site Identification on AmpC β-Lactamase

, 2016
β-Lactamases are the most widespread resistance mechanism to β-lactam antibiotics and are an increasing menace to public health. Several β-lactamase structures have been determined, making this enzyme an attractive target for structure-based drug design.
Rachel A. Powers (1345839), Brian K. Shoichet (434829)   +1 more
core   +1 more source

Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli, Volker Müller, Christoph Welsch, Heiko Mühl, Jonel Trebicka, Volkhard A. J. Kempf   +5 more
wiley   +1 more source

Properties of the β-lactamase specified by thePseudomonasplasmid R151 [PDF]

FEMS Microbiology Letters, 1978
openaire   +1 more source

Experimental Evidence for a Metal‐Related Function of a Cyanobactin

Angewandte Chemie International Edition, Volume 65, Issue 25, 15 June 2026.
Cyanobactins such as patellamides are produced by cyanobacteria profusely and have been studied extensively, but almost exclusively for their cytotoxic properties. Discussed is unprecedented experimental evidence for a metal‐related biological function – likely CO2 transport from the ascidian to the cyanobacterial symbiont.
Philipp Baur, Timothy A. Hill, Kai‐Chen Wu, Junxian Lim, Brett M. Paterson, Gunasekaran Velmurugan, Bernard M. Degnan, David P. Fairlie, Peter Comba   +8 more
wiley   +1 more source

Genetic Relationship Between Heavy Metals Resistance and β- Lactamase Production In E. Coli and Staphylococcus Aureus

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
  This study is a trail to know if the genes controlling some of heavy metals resistance ( lead, zinc, cadmium, cromium) in two types of pathogenic bacteria  E. coli  as gram negative bacteria and S. aureus as gram positive bacteria, present on the β-lactamase plasmid.
openaire   +1 more source

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

In vitro activity of cefiderocol against European Pseudomonas aeruginosa and Acinetobacter spp., including isolates resistant to meropenem and recent β-lactam/β-lactamase inhibitor combinations

Microbiology Spectrum
Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp. represent major threats and have few approved therapeutic options. Non-‍fermenting Gram-negative isolates were collected from hospitalized inpatients from 49 sites in 6 European countries
Anne Santerre Henriksen, Katy Jeannot, Antonio Oliver, John D. Perry, Mathias W. Pletz, Stefania Stefani, Ian Morrissey, Christopher Longshaw   +7 more
doaj   +1 more source

Comprehensive characterization of β-lactamase resistome

, 2022
β-lactamases are enzymes capable of conferring pathogens with resistance against β-lactam antibiotics. They are widely disseminated in clinical pathogens via horizontal gene transfer, which raises major concerns in clinics.
Gholipour, Sevan
core  

Metal‐Dependent Effects and Crowding Robustness of Pseudomonas fluorescens Esterase I

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Pseudomonas fluorescens esterase I retains catalytic activity in metal‐rich and crowded environments, despite metal‐specific inhibitory effects. These findings highlight its robustness for biocatalytic applications in complex environments. Industrial biocatalysts are strongly influenced by their physicochemical environment, yet systematic studies on ...
Emmanouil Ntermanakis, Nikoleta Syngelaki, Alexandros Lyratzakis, Renia Fotiadou, Spyridoula Charova, Ioannis V. Pavlidis, Angeliki Giannouli   +6 more
wiley   +1 more source

MOESM1 of Single nucleotide polymorphisms in genes encoding penicillin-binding proteins in β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Japan

, 2018
Additional file 1. Reference sequences used in this study.
Misawa, Kazuhisa, Tarumoto, Norihito, Tamura, Shinsuke, Osa, Morichika, Hamamoto, Takaaki, Yuki, Atsushi, Kouzaki, Yuji, Imai, Kazuo, Ronald, Runtuwene, Yamaguchi, Toshiyuki, Murakami, Takashi, Maesaki, Shigefumi, Suzuki, Yutaka, Kawana, Akihiko, Maeda, Takuya   +14 more
openaire   +1 more source