Results 201 to 210 of about 37,330 (229)

Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes. [PDF]

J Med Chem
Villamil V, Rossi MA, Mojica MF, Hinchliffe P, Martínez V, Castillo V, Saiz C, Banchio C, Macías MA, Spencer J, Bonomo RA, Vila A, Moreno DM, Mahler G.   +13 more
europepmc   +1 more source

Hydroxyhexylitaconic acids as potent IMP-type metallo-β-lactamase inhibitors for controlling carbapenem resistance in <i>Enterobacterales</i>. [PDF]

Microbiol Spectr
Wachino J-i, Jin W, Norizuki C, Kimura K, Tsuji M, Kurosaki H, Arakawa Y.   +6 more
europepmc   +1 more source

Antimicrobial and Diagnostic Stewardship of the Novel β-Lactam/β-Lactamase Inhibitors for Infections Due to Carbapenem-Resistant Enterobacterales Species and Pseudomonas aeruginosa. [PDF]

Antibiotics (Basel)
Ferous S, Anastassopoulou C, Pitiriga V, Vrioni G, Tsakris A.   +4 more
europepmc   +1 more source

Assessment of the activity and mechanisms of resistance to cefiderocol and combinations of β-lactams and the novel β-lactamase inhibitors avibactam, taniborbactam, zidebactam, nacubactam, xeruborbactam, and ANT3310 in emerging double-carbapenemase-producing Enterobacterales. [PDF]

Antimicrob Agents Chemother
Blanco-Martín T, López-Hernández I, Aracil B, González-Pinto L, Aja-Macaya P, Alonso-García I, Rodríguez-Pallares S, Sánchez-Peña L, Outeda-García M, Pérez-Vázquez M, Vázquez-Ucha JC, Beceiro A, Pascual Á, Bou G, López-Cerero L, Oteo-Iglesias J, Arca-Suárez J, GEMARA-SEIMC/CIBERINFEC Study Group on the activity and resistance mechanisms to new β-lactams and β-lactamase inhibitors (PROTECT).   +17 more
europepmc   +1 more source

Development and Validation of a Capillary Zone Electrophoresis-Tandem Mass Spectrometry Method for Simultaneous Quantification of Eight β-Lactam Antibiotics and Two β-Lactamase Inhibitors in Plasma Samples. [PDF]

Pharmaceuticals (Basel)
Cizmarova I, Mikus P, Svidrnoch M, Piestansky J.   +3 more
europepmc   +1 more source

Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in <i>in vitro</i> media, and novel supplement dosing strategy to mitigate thermal drug degradation. [PDF]

Antimicrob Agents Chemother
Zhou J, Qian Y, Lang Y, Zhang Y, Tao X, Moya B, Sayed ARM, Landersdorfer CB, Shin E, Werkman C, Smith NM, Kim TH, Kumaraswamy M, Shin BS, Tsuji BT, Bonomo RA, Lee RE, Bulitta JB.   +17 more
europepmc   +1 more source

Multigram-scale chemoenzymatic synthesis of diverse aminopolycarboxylic acids as potential metallo-β-lactamase inhibitors.

Org Biomol Chem
Bhat MF, Prats Luján A, Saifuddin M, Fodran P, Poelarends GJ.   +4 more
europepmc   +1 more source

Inhibiting the β-Lactamase of Mycobacterium tuberculosis (Mtb) with Novel Boronic Acid Transition-State Inhibitors (BATSIs)

ACS Infectious Diseases, 2015
BlaC, the single chromosomally-encoded β-lactamase of Mycobacterium tuberculosis, has been identified as a promising target for novel therapies that rely upon β-lactamase inhibition.
Saugata Hazra, Christopher R Bethel, Chiara Romagnoli   +2 more
exaly   +2 more sources