Results 161 to 170 of about 1,672,197 (320)

Human Milk Practices in Swedish Neonatal Units: Results From a Nationwide Survey

Acta Paediatrica, EarlyView.
ABSTRACT Aim The aim of this study was to describe the routines for handling mother's own milk and donor human milk in Swedish neonatal care units related to national guidelines. Methods A web‐based survey of 24 of 38 neonatal units and 19 of 28 human milk banks in Sweden. Results Despite national guidelines, breast milk handling varied widely.
Ylva Thernström Blomqvist, Anna‐My Lund, Fredrik Ahlsson, Jenny Ericson, Charlotta Karlsson, Josefin Lundström, Ingela Sandström, Anna Gustafsson   +7 more
wiley   +1 more source

Site-saturation studies of β-lactamase: Production and characterization of mutant β-lactamases with all possible amino acid substitutions at residue 71 [PDF]

, 1986
A mutagenic technique that "saturates" a particular site in a protein with all possible amino acid substitutions was used to study the role of residue 71 in β-lactamase (EC 3.5.2.6). Threonine is conserved at residue 71 in all class A β-lactamases and is
Richards, John H., Schultz, Steve C.
core  

Altered Pathogen Spectrum of Spontaneous Bacterial Peritonitis in Patients Treated With Proton Pump Inhibitors

Alimentary Pharmacology &Therapeutics, EarlyView.
This multicenter, observational study reveals distinct alterations in the microbial spectrum of spontaneous bacterial peritonitis (SBP) associated with proton pump inhibitor use. These results are especially relevant for guiding empiric antibiotic therapy of SBP.
Philip Kitchen, Sarah L. Schütte, Tammo L. Tergast, Benjamin Maasoumy, Leonie Braun, Ulrich vor dem Esche, Georg Häcker, Marcus M. Mücke, Marlene Reincke, Michael Schultheiss, Robert Thimme, Siegbert Rieg, Dominik Bettinger, Lukas Sturm   +13 more
wiley   +1 more source

Electrochemical sensor for the detection of serine β-lactamase catalytic activity

Chimica Techno Acta
A new approach is proposed based on the use of electrodes modified with carbon nanomaterials to determine enzymatic activity and screening for inhibitors of serine β-lactamases such as extended spectrum β-lactamases (ESBLs). These enzymes are responsible
Victoria V. Shumyantseva, Tatiana V. Bulko, Galina V. Presnova, Vitaly G. Grigorenko, Maya Yu. Rubtsova   +4 more
doaj   +1 more source

Comparative Metagenomics and Network Analyses Provide Novel Insights Into the Scope and Distribution of β-Lactamase Homologs in the Environment

Frontiers in Microbiology, 2019
The β-lactams are the largest group of clinically applied antibiotics, and resistance to these is primarily associated with β-lactamases. There is increasing understanding that these enzymes are ubiquitous in natural environments and henceforth ...
Joao Gatica, Joao Gatica, Edouard Jurkevitch, Eddie Cytryn   +3 more
doaj   +1 more source

Prevalence of ambler class a extended-spectrum- β -lactamases (ESBLS) among Uropathogenic Escherichia coli strains isolated from Rasht city, Iran

Bioscience Journal, 2017
Extended spectrum β-lactamases (ESBLs), a group of bacterial enzymes which are the major cause of resistance to penicillins, broad spectrum cephalosporins and monobactams, are found among the member of Enterobacteriaceae. The class A ESBLs are mainly encoded by the plasmid mediated blaSHV, blaTEM and blaCTX-M genes. In this study, prevalence of Ambler
Zamani, Hojjatolah, Salehzadeh, Ali, Zarrin, Seddigheh   +2 more
openaire   +5 more sources

Intravesical therapy for recurrent urinary tract infection: a systematic review and meta‐analysis

BJU International, EarlyView.
Objective To undertake a systematic review and meta‐analysis to evaluate the efficacy, safety, and clinical applicability of intravesical instillations for preventing recurrent urinary tract infections (rUTIs). Methods PubMed/MEDLINE, Embase, Cochrane CENTRAL, Scopus, and Web of Science were searched from January 2000 to April 2025 for randomised and ...
Matthew Kwon, Asaad Ahmad, Natalie Lott, Alison Blatt   +3 more
wiley   +1 more source

Conformational Dynamics of metallo-β-lactamase CcrA during Catalysis Investigated by Using DEER Spectroscopy [PDF]

, 2015
Previous crystallographic and mutagenesis studies have implicated the role of a position-conserved hairpin loop in the metallo-β-lactamases in substrate binding and catalysis.
Aitha, Mahesh, Bennett, Brian, Crowder, Michael W., Lorigan, Gary A., McCarrick, Robert, Moritz, Lindsay, Roche, Zahilyn, Sahu, Indra D., Sanyurah, Omar   +8 more
core   +2 more sources

Stability and low induction propensity of cefiderocol against chromosomal AmpC β-lactamases of Pseudomonas aeruginosa and Enterobacter cloacae

Journal of Antimicrobial Chemotherapy, 2018
Objectives The siderophore cephalosporin cefiderocol possesses in vitro activity against MDR Gram-negative bacteria. The stability of cefiderocol against serine- and metallo-type carbapenemases has been reported previously, but little is known about how ...
Akinobu Ito, Toru Nishikawa, Merime Ota, Tsukasa Ito-Horiyama, N. Ishibashi, Takafumi Sato, M. Tsuji, Y. Yamano   +7 more
semanticscholar   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source