Results 71 to 80 of about 1,672,197 (320)

\u3cem\u3eArabidopsis thaliana\u3c/em\u3e GLX2-1 Contains a Dinuclear Metal Binding Site, but Is Not a Glyoxalase 2 [PDF]

, 2009
In an effort to probe the structure and function of a predicted mitochondrial glyoxalase 2, GLX2-1, from Arabidopsis thaliana, GLX2-1 was cloned, overexpressed, purified and characterized using metal analyses, kinetics, and UV–visible, EPR, and 1H-NMR ...
Bennett, Brian, Crowder, Michael W., Limphong, Pattraranee, Makaroff, Christopher A.   +3 more
core   +2 more sources

Antimicrobial susceptibility patterns of β-lactamase producing <i>Staphylococcus Aureus</i>

Journal of Armed Forces Medical College, Bangladesh, 1970
doi:10.3329/jafmc.v4i2.1838JAFMC Bangladesh Vol.4(2) 2008 14 ...
Luthunnahar Khan, Jamal Pasha Chowdhury, Nishat Jubaida, Nizamul Karim Khan, Md Eunus Ali Mondal, Narjis Maliha Kawsar   +5 more
openaire   +2 more sources

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Chimeric β-lactamases: global conservation of parental function and fast time-scale dynamics with increased slow motions. [PDF]

PLoS ONE, 2012
Enzyme engineering has been facilitated by recombination of close homologues, followed by functional screening. In one such effort, chimeras of two class-A β-lactamases - TEM-1 and PSE-4 - were created according to structure-guided protein recombination ...
Christopher M Clouthier, Sébastien Morin, Sophie M C Gobeil, Nicolas Doucet, Jonathan Blanchet, Elisabeth Nguyen, Stéphane M Gagné, Joelle N Pelletier   +7 more
doaj   +1 more source

Extended-spectrum beta-lactamases-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru [PDF]

, 2018
Antibiotic resistance mediated by bacterial production of extended‐spectrum beta‐lactamase (ESBL) is a global threat to public health. ESBL resistance is most commonly hospital‐acquired; however, infections acquired outside of hospital settings have ...
A. Appelgren, C. Shiva, C. Tello, D. G. Streicker, J. A. Benavides, J. Solassol, J. Vendrell, M. Virhuez, S. Godreuil, World Health Organization   +9 more
core   +3 more sources

Expression of β-lactamase inCoxiella burnetiitransformants [PDF]

FEMS Microbiology Letters, 2000
Coxiella burnetii can be transformed to ampicillin resistance by electroporation with plasmids encoding beta-lactamase. However, non-plasmid emergence of resistance to ampicillin also develops. To validate the usefulness of the bla gene marker for selection and detection, transformed C.
M L, Suhan, H A, Thompson
openaire   +2 more sources

Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases

Journal of Medicinal Chemistry, 2020
Multidrug resistant Gram-negative bacterial infections are an increasing public health threat due to rapidly rising resistance toward β-lactam antibiotics.
T. Durand-Réville, Janelle Comita-Prevoir, Jing Zhang, Xiaoyun Wu, Tricia L May-Dracka, J. Romero, Frank Wu, April Chen, A. Shapiro, Nicole M. Carter, S. McLeod, R. Giacobbe, J. Verheijen, S. Lahiri, M. Sacco, Yu Chen, J. O’Donnell, Alita A. Miller, John P. Mueller, R. Tommasi   +19 more
semanticscholar   +1 more source

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

Advanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang, Jian Zhang, Yun li, Liping Qiao, Zhuorui Dong, Dandan Cui, Peirong Bai, Liping Li, Bing Cao, Ruiping Zhang   +9 more
wiley   +1 more source

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy, 2019
As shifts in the epidemiology of β-lactamase-mediated resistance continue, carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) are the most urgent threats.
Jodie C. Hamrick, J. Docquier, T. Uehara, C. Myers, David A. Six, Cassandra L. Chatwin, Kaitlyn John, Salvador Vernacchio, S. Cusick, Robert E Trout, C. Pozzi, F. De Luca, M. Benvenuti, S. Mangani, Bin Liu, R. Jackson, G. Moeck, L. Xerri, C. Burns, D. Pevear, Denis M. Daigle   +20 more
semanticscholar   +1 more source

Significance of Self‐Expandable Metallic Stent for Postoperative Intra‐Abdominal Infection After Pancreatoduodenectomy in Patients With a Hard Pancreas

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Self‐expandable metal stents (SEMS) are often used for preoperative biliary drainage in pancreatoduodenectomy (PD); however, their impact on postoperative intra‐abdominal infection (POAI) remains unclear. This study aimed to evaluate the clinical significance of SEMS in relation to POAI.
Kosuke Mori, Haruyoshi Tanaka, Nana Kimura, Mina Fukasawa, Ayaka Itoh, Yoshihiro Shirai, Kazuto Shibuya, Kentaro Nagaoka, Yoshihiro Yamamoto, Tsutomu Fujii   +9 more
wiley   +1 more source