Results 191 to 200 of about 1,666,677 (276)

Pyridine Into Pyrrole Transformation Induced Within the Confinement of the Macrocycle

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
This work demonstrates the nontrivial reactivity of pyridine incorporated into a porphyrin framework. The most significant achievement is the contraction of the six‐membered ring to a pyrrole ring, which is a phenomenon of great interest to researchers in this field.
Paulina Krzyszowska, Agata Burska‐Jabłońska, Mateusz Oberski, Michał J. Białek, Lechosław Latos‐Grażyński, Karolina Hurej   +5 more
wiley   +2 more sources

Resensitizing β-Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment. [PDF]

Adv Sci (Weinh)
Shi T, Wu Q, Ruan Z, Luo Z, Wang W, Guo Z, Ma Y, Wang X, Chu G, Lin H, Ge M, Chen Y.   +11 more
europepmc   +1 more source

First Detection of Lactococcus formosensis subsp. formosensis in Rainbow Trout (Oncorhynchus mykiss) in Europe

Journal of Fish Diseases, Volume 49, Issue 4, April 2026.
ABSTRACT Lactococcus garvieae, Lactococcus petauri and Lactococcus formosensis are etiological agents of piscine lactococcosis, a disease reported in Italy since the early 1990s and linked to significant aquaculture losses. To the best of our knowledge, this study reports the first detection of L. formosensis subsp. formosensis in farmed rainbow trout (
Silvia Colussi, Giuseppe Esposito, Khalid Shahin, Pier Luigi Acutis, Lucio Fariano, Claudio Ghittino, Maria Goria, Fabio Bondavalli, Paolo Ajmone Marsan, Giorgia Bignami, Elena Bozzetta, Marino Prearo, Paolo Pastorino   +12 more
wiley   +1 more source

Photoredox-catalyzed intramolecular nucleophilic amidation of alkenes with β-lactams. [PDF]

Beilstein J Org Chem
Giraldi V, Magagnano G, Giacomini D, Cozzi PG, Gualandi A.   +4 more
europepmc   +1 more source

Amino acid substitutions in PBP3 in Haemophilus influenzae strains, their phenotypic detection and impact on resistance to β-lactams. [PDF]

J Antimicrob Chemother
Jakubu V, Cechova M, Musilek M, Malisova L, Zapletalova B, Zemlickova H.   +5 more
europepmc   +1 more source

Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
An AlphaFold 2 model of a peptide derived from zinc finger translocation associated (ZFTA) protein in complex with the Kelch domain of KLHL20 (KLHL20Kelch). Sensorgrams from surface plasmon resonance biosensor experiments of the interaction between a ZFTA‐derived peptide with immobilised KLHL20Kelch shows that the interaction is complex and has a ...
Nadine E. M. Myers, Joanna Whittaker, Marie Elodie Hélène Cadot, Julia K. Varga, Marcel Diallo, Jakob Nilsson, Anders Bach, Anja Sandström, Ora Schueler‐Furman, U. Helena Danielson   +9 more
wiley   +1 more source

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Comparative evaluation of five β-Lactamase inhibitors in combination with β-Lactams against multidrug-resistant Mycobacterium tuberculosis in vitro. [PDF]

BMC Infect Dis
Shi J, Zheng D, Su R, Ma X, Zhu Y, Wang S, Chang W, Sun D.   +7 more
europepmc   +1 more source

The β‐Lactams Strike Back: Ceftazidime‐Avibactam

Pharmacotherapy, 2015
E. Zasowski, J. Rybak, M. Rybak
semanticscholar   +1 more source

The use of dual β-lactams to restore susceptibility of Mycobacterium avium complex. [PDF]

JAC Antimicrob Resist
Al-Jabri MY, Dousa KM, Wilson BM, Bonomo RA.   +3 more
europepmc   +1 more source