Results 181 to 190 of about 740,410 (298)

Photochemical Cyclization of Tertiary Buta-2,3-dienamides to β-Lactams Upon Triplet Energy Transfer. [PDF]

Angew Chem Int Ed Engl
Hofer J, Bertrams MS, Kerzig C, Bach T.
europepmc   +1 more source

Hypersensitivity to Excipients in Drugs: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Drugs contain active pharmaceutical ingredients and excipients, compounds which enhance the pharmacokinetics, stability and palatability of the pharmaceutical formulation. While most drug hypersensitivity reactions (DHR) are caused by active ingredients, excipients may also be involved.
Lene H. Garvey, Knut Brockow, Annick Barbaud, Charlotte G. Mortz, Gianfranco Calogiuri, Asli Gelincik, Osman O. Yeğit, Alla Nakonechna, Annette Wagner, Rik Schrijvers, Toon Ieven   +10 more
wiley   +1 more source

Beyond β-Lactams: Defining the Role of Eravacycline in Multidrug-Resistant and Metallo-β-Lactamase-Producing Infections. [PDF]

Antibiotics (Basel)
Keck JM.
europepmc   +1 more source

Benefits and Harms of Antenatal/Intrapartum Screening for Maternal Group B Streptococcus and Use of Intrapartum Antibiotic Prophylaxis Versus Risk‐Based Protocols or No Intervention: A Rapid Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim To synthesise evidence on the effectiveness, harms and benefits of different approaches to prevent early‐onset Group B Streptococcus (EOGBS) and identify gaps in short and longer‐term outcomes. Methods A two‐phase rapid review. Phase 1 included an overview of systematic reviews (SRs).
Pauline Campbell, Cathryn Broderick, Candida Fenton, Bridget Davis, Wei Xu, Alex Todhunter‐Brown, Narendra Aladangady, Richard F. Chin, Rosie Hill, Ryan Kean, Charlotte‐Eve Short, Julie Cowie, NESSIE—NIHR Evidence Synthesis Scotland InitiativE   +12 more
wiley   +1 more source

Ceftazidime-avibactam resistance evolution in <i>Pseudomonas aeruginosa</i> and implications for cross-resistance to other novel β-lactams. [PDF]

Antimicrob Agents Chemother
Dorazio AJ, Kline EG, Squires KM, Shah S, Van Tyne D, Wu JY, Pogue JM, Shields RK.   +7 more
europepmc   +1 more source

Base-Promoted C→N Carbonyl Shift Enables One-Step Access to aza-β-Lactams from α-Heteroaryl-α-amino Esters. [PDF]

Org Lett
Kristek J, Št'astná N, Pospíšil J.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

"Cut-and-Sew" Reactions of β-Lactams via C-C Bond Activation. [PDF]

J Am Chem Soc
Kan L, Zhang R, Lu SL, Hari Y, Dong G.
europepmc   +1 more source

Quality and Consistency of Penicillin Allergy Delabelling Guidelines: A Systematic Review

Clinical &Experimental Allergy, EarlyView.
Eighteen penicillin allergy delabelling guidelines from 12 countries were reviewed. There is consensus for staged risk‐based testing, with emerging support for direct oral challenge in low‐risk patients and expanded non‐specialist roles. Overall guideline quality was low, with major gaps in methodological rigour, stakeholder involvement, and ...
Jessie He, Marina Guirguis, Sankare Devanandan, Rani Scott‐Farmer, Sandra Vale, Michaela Lucas, Jennifer J. Koplin, Catherine J. Hornung, Sandra M. Salter   +8 more
wiley   +1 more source

Highly stereoselective synthesis of allylic β-lactams <i>via</i> enzymatic C(sp³)-H amidation. [PDF]

Chem Sci
Jafari NZ, Wang Z, Chattopadhyay A, Roy S, Fasan R.   +4 more
europepmc   +1 more source