Results 201 to 210 of about 1,666,677 (276)

4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL. [PDF]

ACS Med Chem Lett
Ji S, Bach K, Miriyala VM, Dohnálek J, Riopedre-Fernandez M, Lepšík M, van de Plassche M, Vanhoutte R, Barniol-Xicota M, Moreira R, Strisovsky K, Verhelst SHL.   +11 more
europepmc   +1 more source

Chiral Potassium Brønsted Base‐Catalyzed Stereoselective Synthesis of 1,3‐Diols via a Tandem Allylic Isomerization/Asymmetric Aldol–Tishchenko Reaction

Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
Chiral potassium base catalysts featuring 1,1´‐bi‐2‐naphthol‐derived chiral crown ethers as ligands promote a tandem allylic isomerization/asymmetric aldol‐Tishchenko reaction of allylic alcohols and aldehydes. This method provides enantioenriched 1,3‐diols with excellent diastereoselectivity and high enantioselectivity, thereby expanding the synthetic
Hiroki Ishikawa, Masahiro Sai
wiley   +1 more source

A mutation in RNA polymerase imparts resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism. [PDF]

Cell Rep
Patel Y, Helmann JD.
europepmc   +1 more source

Mechanistic Study of the Carbonylation of Aziridines to β-Lactams: Alkylation, Solvent and Molecular NaBr and MgO Clusters Catalysts Effects. [PDF]

J Comput Chem
Jendoubi A, Zouaghi MO, Arfaoui Y, Guégan F, Al-Mogren MM, Hochlaf M.   +5 more
europepmc   +1 more source

Triplet Energy Transfer‐Driven Intermolecular [2+2] Photocycloaddition of Acyclic Imines and Indoles: Facile Access to Azetidine‐Fused Indolines

Advanced Science, Volume 13, Issue 14, 9 March 2026.
An intermolecular aza‐Paternò‐Büchi reaction of indoles and acyclic imines is enabled by visible‐light‐driven triplet energy transfer, providing azetidine‐fused indolines up to 93% yield for 30 examples and providing a novel protocol to access previously inaccessible scaffolds. ABSTRACT Currently, successful examples of the aza‐[2+2] photocycloaddition
Gang Yang, Zeng Han, Hong Zhang, Xiuling Cui   +3 more
wiley   +1 more source

Mutant prevention concentrations and phenotypic and genomic profiling of first-step resistance mechanisms to classical and novel β-lactams in Pseudomonas aeruginosa. [PDF]

Antimicrob Agents Chemother
Sastre-Femenia MÀ, Gomis-Font MA, Oliver A.   +2 more
europepmc   +1 more source

Penicillin allergy de‐labelling in the critical care unit: Simulations to design an intravenous drug provocation test that mirrors the plasma profile of an enteral challenge

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 997-1002, March 2026.
The majority of penicillin allergy labels are incorrect and a label of penicillin allergy is associated with worse outcomes and increased use of healthcare services. Penicillin allergy assessment and de‐labelling may be considered in critically ill patients. An oral penicillin challenge is a common component of most penicillin allergy protocols.
Cleodie Swire, Sean Keane, Reya Vinay Shah, Toqa El‐Nahhas, Iao Lei, Salma Alamin, Niall Conlon, Dagan Osborne Lonsdale   +7 more
wiley   +1 more source

In vitro Evaluation of the Antibacterial Activity of the Combination of Avibactam and β-Lactams Against Highly Virulent Carbapenem-Resistant <i>Klebsiella pneumoniae</i>. [PDF]

Infect Drug Resist
Chang J, Peng X, Wang X, Zhang Z.
europepmc   +1 more source

Isothiourea-catalyzed asymmetric synthesis of β-lactams and β-amino esters from arylacetic acid derivatives and N-sulfonylaldimines.

Journal of Organic Chemistry, 2014
Siobhan R. Smith, James J. Douglas, Hugues Prevet, P. Shapland, A. Slawin, Andrew D. Smith   +5 more
semanticscholar   +1 more source