Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis [PDF]
Journal of Pharmaceutical Analysis, 2018 A simple method was established for the determination of β-propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS).
Longshan Zhao, Xun Gao
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Synthesis and Biodegradation of Poly(l-lactide-co-β-propiolactone) [PDF]
International Journal of Molecular Sciences, 2017 Although the copolymerizations of l-lactide (LA) with seven- or six-membered ring lactones have been extensively studied, the copolymerizations of LA with four-membered ring lactones have scarcely been reported.
Zhengguo Cai +2 more
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Vine-Twining Inclusion Behavior of Amylose towards Hydrophobic Polyester, Poly(β-propiolactone), in Glucan Phosphorylase-Catalyzed Enzymatic Polymerization [PDF]
Life, 2023 This study investigates inclusion behavior of amylose towards, poly(β-propiolactone) (PPL), that is a hydrophobic polyester, via the vine-twining process in glucan phosphorylase (GP, isolated from thermophilic bacteria, Aquifex aeolicus VF5)-catalyzed ...
Masa-aki Iwamoto, Jun-ichi Kadokawa
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Comparison of β-Propiolactone and Formalin Inactivation on Antigenicity and Immune Response of West Nile Virus [PDF]
Advances in Virology, 2015 West Nile Virus (WNV) is a pathogenic arbovirus that belongs to genus Flavivirus under family Flaviviridae. Till now there are no approved vaccines against WNV for human use.
Pritom Chowdhury +3 more
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Antigen anisotropy: The overlooked geometric determinant of vaccine immunogenicity and fidelity [PDF]
Human Vaccines & ImmunotherapeuticsAntigen anisotropy, the directional dependence of protein conformation, epitope exposure, and conformational dynamics, is an under-appreciated determinant of vaccine immunogenicity.
Daniel Santiago
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No evidence of direct activation of human neutrophil responses by multivalent prefusion trimeric SARS-CoV-2 Spike protein ex vivo. [PDF]
PLoS ONEThe SARS-CoV-2 Spike (S) protein is essential for viral entry and serves as the primary immunogen in most COVID-19 vaccines. While its role in adaptive immunity is well defined, its potential to contribute directly to innate immune activation remains ...
Audray Fortin +10 more
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Structural insights from vaccine candidates for EV-D68 [PDF]
Communications BiologyEnterovirus D68 (EV-D68), a member of the Picornaviridae family, causes respiratory illness and can lead to acute flaccid myelitis in children. No specific treatment or vaccine is available.
Jiaxuan Cheng +12 more
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The establishment of a universal standard for both viral antigen and nucleid acid detection based on digital PCR [PDF]
Virology JournalBackground Viral antigen rapid detection tests (Ag-RDTs) and PCR-based nucleic acid amplification tests (NAATs) are essential for diagnosing infections like SARS-CoV-2.
Manyu Li +12 more
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Scent dogs identify SARS-CoV-2-infections in respiratory samples from experimentally infected ferrets and hamsters—a pilot study [PDF]
Frontiers in MedicineRapid and sensitive diagnostic measures are a pre-requisite for the control of SARS-CoV-2 outbreaks. Dogs detect SARS-CoV-2-infected human individuals with high speed due to their extraordinary olfactory acuity.
Claudia Schulz +16 more
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Surface modifications of influenza proteins upon virus inactivation by β‐propiolactone [PDF]
Proteomics, 2013 Terry Cyr, Yi-Min She
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