Results 21 to 30 of about 697,712 (159)

The impact of sample processing on the rapid antigen detection test for SARS-CoV-2: Virus inactivation, VTM selection, and sample preservation

Biosafety and Health, 2021
Many factors have been identified as having the ability to affect the sensitivity of rapid antigen detection (RAD) tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to identify the impact of sample processing on the
Haiwei Zhou, Conghui Wang, Jian Rao, Lan Chen, Tingting Ma, Donglai Liu, Lili Ren, Sihong Xu   +7 more
doaj   +1 more source

Purine-Specific Repair of β-Propiolactone-Induced Dna Damage in Mouse Skin Cells [PDF]

, 1974
The incorporation of tritiated deoxyribonucleosides into DNA was studied during DNA repair in mouse skin cells treated with the skin carcinogen β-propiolactone.
Hennings, Henry, Michael, Delores M., del Ande Eaton, Sol, Morgan, David L.   +3 more
core   +1 more source

An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals

iScience, 2023
Summary: Vaccines have relieved the public health burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and globally inactivated vaccines are most widely used.
Anna Offersgaard, Carlos Rene Duarte Hernandez, Shan Feng, Pavel Marichal-Gallardo, Kenn Holmbeck, Anne Finne Pihl, Carlota Fernandez-Antunez, Garazi Peña Alzua, Katrine Top Hartmann, Long V. Pham, Yuyong Zhou, Karen Anbro Gammeltoft, Ulrik Fahnøe, Uffe Vest Schneider, Gabriel Kristian Pedersen, Henrik Elvang Jensen, Jan Pravsgaard Christensen, Santseharay Ramirez, Jens Bukh, Judith Margarete Gottwein   +19 more
doaj   +1 more source

Theoretical study of the pressure dependent rate constants of the thermal decomposition of β-propiolactone [PDF]

, 2015
A theoretical study of the thermal decomposition of β-propiolactone is carried out using ab initio molecular orbital (MO) methods at the MP2/6-311+G∗∗ level and Rice–Ramsperger–Kassel–Marcus (RRKM) theory.
Zahedi, Ehsan, Shiroudi, Abolfazl, Abolfazl Shiroudi, Ehsan Zahedi   +3 more
core   +1 more source

Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies

Emerging Microbes and Infections, 2021
The unprecedented in recent history global COVID-19 pandemic urged the implementation of all existing vaccine platforms to ensure the availability of the vaccines against COVID-19 to every country in the world.
Liubov I. Kozlovskaya, Anastasia N. Piniaeva, Georgy M. Ignatyev, Ilya V. Gordeychuk, Viktor P. Volok, Yulia V. Rogova, Anna A. Shishova, Anastasia A. Kovpak, Yury Yu. Ivin, Liliya P. Antonova, Kirill M. Mefyod, Lyubov S. Prokosheva, Anna S. Sibirkina, Yuliya Yu. Tarasova, Ekaterina O. Bayurova, Olga S. Gancharova, Victoria V. Illarionova, Grigory S. Glukhov, Olga S. Sokolova, Konstantin V. Shaitan, Anastasia M. Moysenovich, Stanislav A. Gulyaev, Tatiana V. Gulyaeva, Andrey V. Moroz, Larissa V. Gmyl, Elena G. Ipatova, Mikhail P. Kirpichnikov, Alexey M. Egorov, Aleksandra A. Siniugina, Aydar A. Ishmukhametov   +29 more
doaj   +1 more source

Assessments of different inactivating reagents in formulating transmissible gastroenteritis virus vaccine

Virology Journal, 2020
Background Transmissible gastroenteritis virus (TGEV) causes enteric infection in piglets, characterized by vomiting, severe diarrhea and dehydration, and the mortality in suckling piglets is often high up to 100%.
Fujie Zhao, Lintao Liu, Menglong Xu, Xiangli Shu, Lanlan Zheng, Zhanyong Wei   +5 more
doaj   +1 more source

Immunogenicity of Adjuvanted Psoralen-Inactivated SARS-CoV-2 Vaccines and SARS-CoV-2 Spike Protein DNA Vaccines in BALB/c Mice

Pathogens, 2021
The development of a safe and effective vaccine to protect against COVID-19 is a global priority due to the current high SARS-CoV-2 infection rate. Currently, there are over 160 SARS-CoV-2 vaccine candidates at the clinical or pre-clinical stages of ...
Appavu K. Sundaram, Daniel Ewing, Zhaodong Liang, Vihasi Jani, Ying Cheng, Peifang Sun, Kanakatte Raviprakash, Shuenn-Jue Wu, Nikolai Petrovsky, Gabriel Defang, Maya Williams, Kevin R. Porter   +11 more
doaj   +1 more source

Comparative Characteristics of Inactivation Agents for HFRS Vaccine Development

Эпидемиология и вакцинопрофилактика, 2018
The results of various methods of Puumala virus inactivation, including ultraviolet rays (UV), β -propiolactone (BPL) and formalin are presented. Immunogenicity of vaccine preparations obtained using these virus inactivation methods did not differ ...
C. C. Kurashova, A. A. Ishmukhametov, M. C. Egorova, M. V. Balovneva, T. K. Dzagurova, E. A. Tkachenko   +5 more
doaj   +1 more source

Comparison of viral inactivation methods on the characteristics of extracellular vesicles from SARS‐CoV‐2 infected human lung epithelial cells

Journal of Extracellular Vesicles, 2022
The interaction of SARS‐CoV‐2 infection with extracellular vesicles (EVs) is of particular interest at the moment. Studying SARS‐CoV‐2 contaminated‐EV isolates in instruments located outside of the biosafety level‐3 (BSL‐3) environment requires knowing ...
Supasek Kongsomros, Nutkridta Pongsakul, Jirawan Panachan, Ladawan Khowawisetsut, Jinjuta Somkird, Chak Sangma, Tapanee Kanjanapruthipong, Patompon Wongtrakoongate, Arthit Chairoungdua, Kovit Pattanapanyasat, David S. Newburg, Ardythe L. Morrow, Suradej Hongeng, Arunee Thitithanyanont, Somchai Chutipongtanate   +14 more
doaj   +1 more source

Anionic Ring-Opening Polymerization of β-Alkoxymethyl-Substituted β-Lactones [PDF]

, 2016
We report on anionic ring-opening polymerization (ROP) of racemic β-(methoxymethyl)-β-propiolactone (MOMPL) and β-(ethoxymethyl)-β-propiolactone (EOMPL) initiated by supramolecular complex of potassium acetate and tetrabutylammonium acetate (Bu4N+Ac) as ...
Marek Kowalczuk (703904), Grażyna Adamus (2455705)   +1 more
core   +1 more source