Results 11 to 20 of about 51,483 (212)

Vitamin D, Calcium and Phosphor in Patients with β-Thalassemia Major [PDF]

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2019
There has been many reports that patients with β-thalassemia major have bone problems such as thinning of the bone, bone fragility and pathological fractures. For so many years it was believed that the bone problems is mainly caused by marrow expansion due to compenstation of the bone marrow to handle the chronic anaemia and hiypoxia in β-thalassemia
Ade Hariza Harahap, Bidasari Lubis, Herman Hariman   +2 more
openaire   +1 more source

Prevalence of iron-deficiency anemia in pregnant women with various thalassemia genotypes: Thoughts on iron supplementation in pregnant women with thalassemia genes

Frontiers in Nutrition, 2022
BackgroundThere are limited studies on iron-deficiency anemia (IDA) in carriers of various thalassemia genotypes. However, for pregnant women (PW) with high iron demand, ignoring the phenomenon of carrying the thalassemia genes combined with IDA may lead
Min Wang, Xiaozhuang Zhang, Yanhong Zhao, Yubin Zhang, Yan Lin, Meifang Xiao, Ling Li   +6 more
doaj   +1 more source

Two novel deletion mutations in β-globin gene cause β-thalassemia trait in two Chinese families

Human Genomics, 2023
Background β-Thalassemia is mainly caused by point mutations in the β-globin gene cluster. With the rapid development of sequencing technic, more and more variants are being discovered.
Xiuqin Bao, Danqing Qin, Jicheng Wang, Jing Chen, Cuize Yao, Jie Liang, Kailing Liang, Yixia Wang, Yousheng Wang, Li Du, Aihua Yin   +10 more
doaj   +1 more source

Alpha-Hemoglobin Stabilizing Protein Gene Polymorphism (rs4499252 A/G) and its Association with Beta-Thalassemia Major in Iraqi Patients [PDF]

Archives of Razi Institute, 2022
Beta thalassemia (β-thalassemia) major is a genetic disorder of hemoglobin production that results in a diminished rate of synthesis of one or more of the globin chains causing variable degrees of anemia.
M Adnan Khalaf, B. Q Hasan Al-Saadi, H Qassim Mohammed, S Hussein Ewaid   +3 more
doaj   +1 more source

Alpha and beta-Thalassemia mutations in Hubei area of China

BMC Medical Genetics, 2020
Background Thalassemia is a group of inherited hemoglobic disorders resulting from defects in the synthesis of one or more of the hemoglobin chains, which is one of the most prevalent inherited disorders in southern China.
Yaowu Zhu, Na Shen, Xiong Wang, Juan Xiao, Yanjun Lu   +4 more
doaj   +1 more source

Protein C and Protein S Levels in β-Thalassemia Major Patients in Erbil, Kurdistan Region

Cellular and Molecular Biology, 2020
Oxygen is transported in the blood through red blood cells and a protein called hemoglobin. The protein consists of two alpha and two beta chains. The lack of any of these chains is caused by the malfunction of the genes that produce them, and can lead to a genetic disease called thalassemia.
Tareefa Kakakhan, Hadi, Nawsherwan Sadiq, Mohammad, Saran Abdulqadir, Nooruldin   +2 more
openaire   +3 more sources

Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]

, 2017
Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Ali, Bassam R., Chondrou, Vasiliki, John, Anne, Kastrinou, Vlasia, Katsila, Theodora, Kolovos, Petros, Kourakli, Alexandra, Papachatzopoulou, Adamantia, Patrinos, George P., Pavlidaki, Alexia, Sgourou, Argyro, Symeonidis, Argiris   +11 more
core   +5 more sources

Immunity to Pneumococcal Vaccine in Splenectomized β-Thalassemia Patients [PDF]

American Journal of Immunology, 2012
Problem statement: Splenectomy is accompanied by a lifelong risk of overwhelming post splenectomy infection, mainly caused by encapsulated bacteria such as Streptococcus pneumoniae. The mortality rate in those infected patients remains high. Therefore the pneumococcal polysaccharide vaccine has been recommended.
openaire   +1 more source

Role of Iron Chelators, Hydroxyurea, and Splenectomy on Serum Total Antioxidant Capacity in β-Thalassemia

Open Access Macedonian Journal of Medical Sciences, 2020
BACKGROUND: Iron overload is the main cause of oxidative stress in beta-thalassemia (βT) by the increased production of free radicals and reactive oxygen species. Antioxidants counteract the toxic effects of oxidative stress. AIM: This study aims to evaluate the total antioxidant capacity (TAC) and the possible impact of splenectomy, iron chelators ...
Talaat, Ahmed, Abdallah Ismail, Nagwa, Adolf Habib, Sonia, Orban, Hisham A.   +3 more
openaire   +2 more sources

Thalassemia intermedia in HbH-CS disease with compound heterozygosity for β-thalassemia: challenges in hemoglobin analysis and clinical diagnosis [PDF]

, 2009
Co-inheritance of α-thalassemia with homozygosity or compound heterozygosity for β-thalassemia may ameliorate β-thalassemia major. A wide range of clinical phenotypes is produced depending on the number of α-thalassemia alleles (-α/αα --/αα, --/-α).
George, Elizabeth, Kok, Juan Loong, Tan, Kim Lian, Tan, Mary Anne Jin Ai, Wee, Yong Chui   +4 more
core   +1 more source