Results 31 to 40 of about 50,706 (199)
Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]
, 2014 Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas +5 more
core +1 more source
Frontiers in Genetics, 2022 Background: Thalassemia is a common inherited hematological disease with genetic disorders characterized by imbalanced synthesis of the globin chains.
Jingxian Ding +5 more
doaj +1 more source
An Aγ-globin G->A gene polymorphism associated with β(0)39 thalassemia globin gene and high fetal hemoglobin production [PDF]
, 2017 Increase of the expression of γ-globin gene and high production of fetal hemoglobin (HbF) in β-thalassemia patients is widely accepted as associated with a milder or even asymptomatic disease. The search for HbF-associated polymorphisms (such as the XmnI,
Bianchi, Nicoletta +10 more
core +1 more source
Archives of Medical Science, 2020 Introduction Elevated hemoglobin (Hb) A 2 is an important diagnostic marker for β-thalassemia carriers. However, diagnosis of cases with borderline Hb A 2 may be problematic.
Hataichanok Srivorakun +4 more
doaj +1 more source
Evaluation of the Association of Transferrin Receptor Type 2 Gene Mutation (Y250X) with Iron Overload in Major β-Thalassemia [PDF]
Archives of Razi Institute, 2021 Thalassemia is an inherited blood disorder in which the body produces defective hemoglobin. One of the important processes to reduce the complication of major β-thalassemia is blood transfusion that leads to elevated ferritin levels in the blood.
J Abdulmalek Jaafar, N. A. M Al-Rashedi
doaj +1 more source
Study of discriminant factor M/H ratio in screening for β thalassemia trait
IP Journal of Diagnostic Pathology and Oncology, 2020 Introduction: Beta Thalassemia syndrome is a group of hereditary disorders characterized by genetic deficiency in the synthesis of beta globin chains located on chromosome 11. A major diagnostic challenge is to differentiate between mild microcytic hypochromic anaemia due to BTT from other causes such as iron deficiency (IDA), sideroblastic anaemia etc.
openaire +2 more sources
Correlation of BACH1 and hemoglobin E/Beta-thalassemia globin expression [PDF]
, 2016 Objective: The diverse clinical phenotype of hemoglobin E (HbE)/β-thalassemia has not only confounded clinicians in matters of patient management but has also led scientists to investigate the complex mechanisms involved in maintaining the delicate red ...
Abdullah, Maha +6 more
core +2 more sources
Epigenetic Insights and Potential Modifiers as Therapeutic Targets in β–Thalassemia
Biomolecules, 2021 Thalassemia, an inherited quantitative globin disorder, consists of two types, α– and β–thalassemia. β–thalassemia is a heterogeneous disease that can be asymptomatic, mild, or even severe.
Nur Atikah Zakaria +7 more
doaj +1 more source
Bali Medical Journal, 2019 Background: Thalassemia is the most common hereditary blood disorder in the world and Indonesia. Major β-thalassemia is classified as Transfusion-Dependent Thalassemia (TDT). Specific changes in the composition of red cell membrane lipids and hemosiderosis may lead to hypercoagulation.
Jane Tetraulina Silitonga +2 more
openaire +1 more source
Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512), 2017 A representative sample of a thousand volunteer university students was screened for evidence of thalassemia minor.Complete blood counts using automated blood cell analysers and blood smears were examined. Patients having anemia, abnormal red cell indices or morphological features of thalassemia minor like hypochromia, microcytosis, target ...
Abdulkadir A. Alnakshabandi +1 more
openaire +3 more sources