Results 41 to 50 of about 51,483 (212)

Thalassemia and erythroid transcription factor KLF1 mutations associated with borderline hemoglobin A2 in the Thai population

Archives of Medical Science, 2020
Introduction Elevated hemoglobin (Hb) A 2 is an important diagnostic marker for β-thalassemia carriers. However, diagnosis of cases with borderline Hb A 2 may be problematic.
Hataichanok Srivorakun, Wachiraporn Thawinan, Goonnapa Fucharoen, Kanokwan Sanchaisuriya, Supan Fucharoen   +4 more
doaj   +1 more source

Epigenetic Insights and Potential Modifiers as Therapeutic Targets in β–Thalassemia

Biomolecules, 2021
Thalassemia, an inherited quantitative globin disorder, consists of two types, α– and β–thalassemia. β–thalassemia is a heterogeneous disease that can be asymptomatic, mild, or even severe.
Nur Atikah Zakaria, Md Asiful Islam, Wan Zaidah Abdullah, Rosnah Bahar, Abdul Aziz Mohamed Yusoff, Ridhwan Abdul Wahab, Shaharum Shamsuddin, Muhammad Farid Johan   +7 more
doaj   +1 more source

Evaluation of the Association of Transferrin Receptor Type 2 Gene Mutation (Y250X) with Iron Overload in Major β-Thalassemia [PDF]

Archives of Razi Institute, 2021
Thalassemia is an inherited blood disorder in which the body produces defective hemoglobin. One of the important processes to reduce the complication of major β-thalassemia is blood transfusion that leads to elevated ferritin levels in the blood.
J Abdulmalek Jaafar, N. A. M Al-Rashedi
doaj   +1 more source

Clinical and hematological characteristics of beta-plus thalassemia and uncommon beta-chain hemoglobin variants in Northern Thailand

Annals of Medicine
Background Thalassemia is the most common hereditary anemia worldwide. Beta-thalassemia results from mutations in HBB gene, causing either absent (β0) or decreased (β+) production of β-globin.
Punwadee Rukwong, Rungrote Natesirinilkul, Lalita Sathitsamitphong, Chane Choed-Amphai, Adisak Tantiworawit, Kanda Fanhchaksai, Supawadee Maneekesorn, Pimlak Charoenkwan   +7 more
doaj   +1 more source

MOESM1 of A validated cellular biobank for β-thalassemia

, 2016
Additional file 1: Table S1. List of the subjects (patients and healthy subjects) present in the Thal-Biobank.
Cosenza, Lucia, Breda, Laura, Breveglieri, Giulia, Zuccato, Cristina, Finotti, Alessia, Lampronti, Ilaria, Borgatti, Monica, Chiavilli, Francesco, Gamberini, Maria, Satta, Stefania, Manunza, Laura, Martis, Franca, Moi, Paolo, Rivella, Stefano, Gambari, Roberto, Bianchi, Nicoletta   +15 more
openaire   +1 more source

BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT. [PDF]

, 2014
The genetic background of donor and recipient is an important factor determining the outcome of allogeneic hematopoietic SCT (allo-HSCT). We applied whole-genome analysis to investigate genetic variants - other than HLA class I and II - associated with ...
Andreani M, Angius A, Bacchetta R., Bulfone A, Ciceri F, Fleischhauer K, Floris M, Gregori S, LA NASA, GIORGIO, Lucarelli G, Marktel S, Piras I. S, Roncarolo M. G, Testi M   +13 more
core   +1 more source

Molecular Epidemiology and Hematologic Characterization of Thalassemia in Guangdong Province, Southern China

Clinical and Applied Thrombosis/Hemostasis, 2022
Introduction: About 2% of the population in the world are carriers of the thalassemia gene. Thalassemia is highly prevalent in Southern China, and traditional clinical testing methods would cause missed diagnosis of partial static thalassemia.
Jiajia Xian MD, Yanchao Wang MD, Jianchun He MD, Shaoying Li MD, Wenzhi He MD, Xiaoyan Ma MD, Qing Li PhD   +6 more
doaj   +1 more source

TyG index and insulin resistance in beta-thalassemia [PDF]

, 2015
Insulin resistance (IR) underlies some glucose metabolism abnormalities in thalassemia major. Recently, triglyceride glucose index (TyG) has been proposed for evaluating insulin resistance as a simple, low cost, and accessible tool.
Fayaz, M., Hosseini, S.M., Jamshir, M., Mirbehbahani, N.   +3 more
core   +1 more source

MOESM2 of A validated cellular biobank for β-thalassemia

, 2016
Additional file 2: Table S2. HbF and HbA2 production in ErPC cultures from 14 β-thalassemia patients after 4 and 8 days differentiation.
Cosenza, Lucia, Breda, Laura, Breveglieri, Giulia, Zuccato, Cristina, Finotti, Alessia, Lampronti, Ilaria, Borgatti, Monica, Chiavilli, Francesco, Gamberini, Maria, Satta, Stefania, Manunza, Laura, Martis, Franca, Moi, Paolo, Rivella, Stefano, Gambari, Roberto, Bianchi, Nicoletta   +15 more
openaire   +1 more source

Differential expression and clinical significance of miR-124-3p in β-thalassemia [PDF]

Jichu yixue yu linchuang
Objective To investigate the differential expression of miR-124-3p in peripheral blood and clinical significance of patients with β-thalassemia. Methods Peripheral blood samples were collected from 33 patients with β-thalassemia and 30 healthy controls
CAO Luoyuan, DONG Wenxu, YANG Jing, GUO Liwen, LU Jiaojiao, ZHENG Xian, FU Xianguo
doaj   +1 more source