Results 111 to 120 of about 33,979 (285)

Transduction of γδ T cells with Baboon envelope pseudotyped lentiviral vector encoding chimeric antigen receptors for translational and clinical applications

Frontiers in Immunology
γδ T cells represent a promising cell platform for adoptive cell therapy. Their natural anti-tumor reactivity and HLA-independent target cell recognition make them an attractive platform for allogeneic adoptive immunotherapy clinical interventions ...
Lorraine Pinot, Lorraine Pinot, Aylin Saßor, Aylin Saßor, Nina Möker, Congcong Zhang, Els Verhoeyen, Els Verhoeyen, José Villacorta Hidalgo, Rimas J. Orentas   +9 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

ROS‐Responsive Nanobubbles for Dual‐Enhanced Ultrasound and Magnetic Resonance Imaging of Tumor Oxidative Stress

Advanced Science, EarlyView.
We report the development of biotinylated PEGylated bilirubin‐coated perfluoropentane (bt‐PEG‐BR@PFP) nanobubbles, a novel class of ROS‐activatable and dual‐modality contrast agents that amplify both ultrasound (US) and magnetic resonance imaging (MRI) signals in response to elevated ROS.
Wonsik Jung, Youngju Son, Dong Yun Lee, Youngeun Jeon, Muhammad Asaddudin, Sung‐Hong Park, Sangyong Jon   +6 more
wiley   +1 more source

Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells

Journal of Hematology & Oncology, 2016
Background Adoptive immunotherapy is gaining momentum to fight malignancies, whereby γδ T cells have received recent attention as an alternative cell source as to natural killer cells and αβ T cells.
Heleen H. Van Acker, Sébastien Anguille, Yannick Willemen, Johan M. Van den Bergh, Zwi N. Berneman, Eva Lion, Evelien L. Smits, Viggo F. Van Tendeloo   +7 more
doaj   +1 more source

Structure of a fully assembled γδ T cell antigen receptor. [PDF]

Nature
T cells in jawed vertebrates comprise two lineages, αβ T-cells and γδ T-cells, defined by the antigen receptors they express, i.e., αβ and γδ T-cell receptors (TCRs), respectively. The two lineages have different immunological roles, requiring γδ TCRs to
Gully BS, Ferreira Fernandes J, Gunasinghe SD, Vuong MT, Lui Y, Rice MT, Rashleigh L, Lay CS, Littler DR, Sharma S, Santos AM, Venugopal H, Rossjohn J, Davis SJ.   +13 more
europepmc   +2 more sources

γδ T cell update:Adaptate orchestrators of immune surveillance

, 2019
As interest in γδ T cells grows rapidly, what key points are emerging, and where is caution warranted? γδ T cells fulfill critical functions, as reflected in associations with vaccine responsiveness and cancer survival in humans and ever more phenotypes ...
Hayday, Adrian C.; id_orcid
core   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

γδ T cells in hematological malignancies: mechanisms and therapeutic strategies

Blood Science
γδ T cells are a unique subset of lymphocytes with both innate and adaptive features. They recognize and eradicate various hematological malignancies through different mechanisms, employing factors including γδ TCR, NKR, NKG2D, TRAIL, and perforin ...
Xingchi Chen, Guangyu Sun, Xiaoyu Zhu
doaj   +1 more source

Ex vivo expanded patient-derived γδ T-cell immunotherapy enhances neuroblastoma tumor regression in a murine model

OncoImmunology, 2019
An effective therapy regimen for relapsed/refractory high-risk neuroblastoma (NB) includes the anti-GD2 monoclonal antibody, dinutuximab, in combination with temozolomide and irinotecan, supporting a role for chemo-immunotherapy in NB.
Jaquelyn T. Zoine, Kristopher A. Knight, Lauren C. Fleischer, Kathryn S. Sutton, Kelly C. Goldsmith, Christopher B. Doering, H. Trent Spencer   +6 more
doaj   +1 more source

γδ T cells shape memory-phenotype αβ T cell populations in non-immunized mice [PDF]

, 2019
Size and composition of γδ T cell populations change dramatically with tissue location, during development, and in disease. Given the functional differentiation of γδ T cell subsets, such shifts might alter the impact of γδ T cells on the immune system ...
Andrew Getahun (314428), Rebecca L. O’Brien (6876824), Deming Sun, O’Brien, Rebecca R.L., Phalke, Swati, Richard L. Reinhardt (6876821), Born, Willi, Born, Willi W.K., Huang, Yafei, Richard L Reinhardt, Deming Sun (316402), Phalke, Swati Popat, Reinhardt, Richard, OBrien, Rebecca, Willi K Born, Kira Rubtsova (3361325), Swati Popat Phalke, Rubtsova, Kira, Yafei Huang, Kira Rubtsova, Reinhardt, Richard Lee, Andrew Getahun, Rebecca L O'Brien, Yafei Huang (539526), Willi K. Born (2502952), Sun, Deming, Swati Popat Phalke (6876818), Getahun, Andrew   +27 more
core   +1 more source