Results 131 to 140 of about 33,979 (285)

Effective γδ T‐cell clinical therapies: current limitations and future perspectives for cancer immunotherapy

Clinical & Translational Immunology
γδ T cells are a unique subset of T lymphocytes, exhibiting features of both innate and adaptive immune cells and are involved with cancer immunosurveillance. They present an attractive alternative to conventional T cell‐based immunotherapy due, in large
Isabella A Revesz, Paul Joyce, Lisa M Ebert, Clive A Prestidge   +3 more
doaj   +1 more source

Enhancing Immunotherapy in Endometrial Cancer: Targeting PD-1 on γδ T Cells

Endometrial cancer (EC), the most prevalent gynecological malignancy, has shown a rising incidence and mortality in recent years. Standard treatments primarily involve surgery and/or chemotherapy.
Valentina Cazzetta, Barbara Fiamengo, Domenico Mavilio, Paolo Marzano, Domenico Vitobello, Sara Terzoli, Joanna Mikulak   +6 more
core  

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Programmable Multi‐Axially Aligned Aerogels via Sequential Freeze‐Casting for Tailored Anisotropy and Tunable Mechanics

Advanced Science, EarlyView.
Conventional single‐gradient freeze‐casting typically produces unidirectional porous architectures with limited transverse connectivity. The Sequential Hybridization by Infiltration and Freeze‐casting Technique (SHIFT) addresses this constraint by integrating secondary aligned structures within a preformed primary scaffold.
Kiho Sung, Sungchul Shin
wiley   +1 more source

PTPN2 regulates T cell lineage commitment and αß versus γδ specification

, 2017
In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αβ T cell receptor (TCR) T cells and non-MHC ...
Dodd, GT, Wiede, F, Godfrey, DI, Strasser, A, Tiganis, T, Butt, T, Boyd, RL, Dudakov, JA, Lu, KH   +8 more
core   +1 more source

Atomically Modulating Competing Exchange Interactions in Centrosymmetric Skyrmion Hosts GdRu2X2 (X = Si and Ge)

Advanced Electronic Materials, EarlyView.
Our work bridges the gap between skyrmion discovery and material design by demonstrating how atomic‐scale control of exchange interactions enables tunable skyrmion phase transitions in centrosymmetric magnetic metals. ABSTRACT Magnetic skyrmions are topologically protected spin states that hold promise for shaping the future of electronics.
Dasuni N. Rathnaweera, Xudong Huai, K. Ramesh Kumar, Michał J. Winiarski, Tomasz Klimczuk, Allana G. Iwanicki, Satya K. Kushwaha, Martin Mourigal, Tyrel M. McQueen, Thao T. Tran   +9 more
wiley   +1 more source

Emerging Memory and Device Technologies for Hardware‐Accelerated Model Training and Inference

Advanced Electronic Materials, EarlyView.
This review investigates the suitability of various emerging memory technologies as compute‐in‐memory hardware for artificial intelligence (AI) applications. Distinct requirements for training‐ and inference‐centric computing are discussed, spanning device physics, materials, and system integration.
Yoonho Cho, Dae‐won Kim, Yujin Kim, Jung‐Heum Na, Yuwon Jeong, Dong‐Yeop Lee, Shinhyun Choi   +6 more
wiley   +1 more source

γδ T cells shape preimmune peripheral B cell populations

, 2016
We previously reported that selective ablation of certain γδ T cell subsets, rather than removal of all γδ T cells, strongly affects serum Ab levels in nonimmunized mice.
O'Brien, Rebecca L., Born, Willi K., Ikuta, Koichi, Heiser, Ryan A., Huang, Yafei, Aviszus, Katja, Wysocki, Lawrence J., Kirchenbaum, Greg A., Casper, Tamara L., Cambier, John C., Huang, Chunjian, Aydintug, M. Kemal, Carding, Simon R., Getahun, Andrew, Detanico, Thiago O., Huang, Hua   +15 more
core   +1 more source

Emerging Materials and Future Strategies for Solid Oxide Electrochemical Cells

Advanced Energy Materials, EarlyView.
Solid oxide electrochemical cells operate under strongly coupled electrochemical and thermodynamic conditions, where performance is constrained by interactions among crystal structure, defect chemistry, and interfacial evolution. This review, based on a structure‐defect‐property‐durability framework, reveals the roles of lattice symmetry and defect ...
Qiuchun Lu, Yufei Zhang, Han Zhao, Pooi See Lee, Daniel H.C. Chua   +4 more
wiley   +1 more source

A Highly Hydrophilic Air Electrode With Water‐Induced Surface Reconstruction for Efficient Reversible Protonic Ceramic Cell at Low Water Partial Pressures

Advanced Energy Materials, EarlyView.
This work demonstrates a new strategy for reversible protonic ceramic cells (R‐PCCs). By developing highly hydrophilic oxides, efficient operation is achieved under low water vapor pressures while maintaining high performance and stability. This approach addresses the challenge of hydrogen production in freshwater‐scarce regions.
Nai Shi, Yun Xie, Xueyu Hu, Junji Hyodo, Chun‐Kuo Peng, Gaopeng Zhou, Hanwen Liu, Bingbing Qiu, Daqin Guan, Jiayi Tang, Yan‐Gu Lin, Ranran Peng, Moses Oludayo Tadé, Meilin Liu, Yoshihiro Yamazaki, Zongping Shao   +15 more
wiley   +1 more source