Results 101 to 110 of about 29,069 (201)

APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Amyloid beta peptide (Aβ) accumulation in the brain is an Alzheimer´s disease (AD) hallmark. Sleep disturbances hamper Aβ production and clearance, thereby exacerbating the Aβ burden. The mechanisms involved remain unclear. We reported that amyloid precursor protein (APP), the Aβ source, possesses intracellular signaling that ...
Clémentine Puech, Anjana Sadanand, Neil Coleman, Marilyn Ikhane, Mohammad Badran, Rong Wang, David Gozal, Angèle T. Parent   +7 more
wiley   +1 more source

OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin [PDF]

, 2013
Jonghee Han, Sunmin Jung, Jiyeon Jang, Tae‐In Kam, Hyunwoo Choi, Byung-Ju Kim, Jihoon Nah, Dong‐Gyu Jo, Toshiyuki Nakagawa, Masaki Nishimura, Yong‐Keun Jung   +10 more
openalex   +1 more source

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M. A. D. Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey‐Smith, Ralph Martins, Prashant Bharadwaj   +9 more
wiley   +1 more source

EC‐01‐02: Structure of Γ‐Secretases and Implications for Drug Development [PDF]

, 2016
Xiao‐chen Bai, Eeson Rajendra, Ganghui Yang, Yigong Shi, Sjors H. W. Scheres   +4 more
openalex   +1 more source

The Molecular Mechanism and Therapeutic Progress in Glomus Tumor

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Glomus tumor (GT) is a rare mesenchymal neoplasm presumed to originate from the neuromyoarterial glomus body. Its pathogenesis is complex and involves alterations in multiple genes and signaling pathways. In the era of precision medicine, increased molecular research has begun to elucidate the oncogenic drivers of GT, offering novel
Zhi Cheng Jiang, Zu Jue Cheng, Jue Xian Xiao, You Quan Huang, Zheng Ke, Jing Hui Xu, Xiang Kun Fu, Hui Huang   +7 more
wiley   +1 more source

Mutations Alter Conformations and Dynamics of APP‐TMDs: An RDC Analysis

ChemistryEurope, Volume 4, Issue 2, February 2026.
How γ‐secretase selects its substrates has been an enigma because of the lack of a consensus sequence. Using residual dipolar couplings, we analyzed the conformations of one substrate and two mutants. Using snapshots of a molecular dynamics trajectory, we analyzed how well structures matched the measured RDC values.
Franziska Krause, Celine Moser, David Elsing, Mara Silber, Fabian Hoffmann, Yannik Woordes, Burkhard Luy, Claudia Muhle‐Goll   +7 more
wiley   +1 more source

β‐Asarone Attenuates Neuroinflammation of Alzheimer's Disease by Activating Autophagy and Suppressing NLRP3 Inflammasome Assembly

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
β‐amyloid activates microglia via the TLR/NF‐κB pathway and primes the NLRP3 inflammasome, driving neuroinflammation. β‐asarone counteracts this by activating autophagy, which degrades NLRP3 components and inhibits inflammasome assembly. This reduces IL‐1β maturation, suppresses cytokine release, and alleviates neuronal damage and cognitive deficits in
Zhiwei Xu, Wanying Xu, Jinxin He, Jiahui Qian, Hui Wang, Changyu Li, Xiaojie Zhou   +6 more
wiley   +1 more source

β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology [PDF]

, 2012
Xiaosong Liu, Xiaohui Zhao, Xianglu Zeng, Koen Bossers, Dick F. Swaab, Jian Zhao, Gang Pei   +6 more
openalex   +1 more source

Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Female‐specific bone loss in Alzheimer's disease mouse models: There is a significant alteration of bone phenotype during Alzheimer's disease. Using integrated imaging and biological assays, we observed changes in the bone microarchitecture, composition, and function in PSEN K1 and PSEN1/hAPP Tg+ mice, predominantly in the females. ABSTRACT Accelerated
Vidyani Suryadevara, Connor J. Krehbial, Anuradha K. Valiya, Melinda Vang, Julian Balanta‐Melo, Pierre P. Eleniste, Sumana Posritong, Jung Min Hong, Katie Chester, Gabriel M. Pagnotti, Teresita Bellido, Monte S. Willis, Angela Bruzzaniti   +12 more
wiley   +1 more source

The insider's perspective: The intracellular complosome and immune cell dynamics in cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Intracellular complement (complosome) shapes the tumour immune microenvironment. Complosome's role in cancer is underrecognised yet central to tumour immunity. C3/C5‐driven complosome signals rewire T‐cell activation, fate and metabolism. Complosome activity can promote pro‐tumour immune cell function.
Alexandra Bennion, Joanne Lysaght, Niamh Lynam‐Lennon   +2 more
wiley   +1 more source