Results 161 to 170 of about 29,069 (201)

Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP. [PDF]

EMBO J, 2022
Petit D, Hitzenberger M, Koch M, Lismont S, Zoltowska KM, Enzlein T, Hopf C, Zacharias M, Chávez-Gutiérrez L.   +8 more
europepmc   +1 more source

Presenilins and the γ-secretase: still a complex problem [PDF]

, 2010
David H. Small, David W. Klaver, Lisa Foa   +2 more
openalex   +1 more source

Supplementary Figure 1, Table 1 from <i>De novo</i> Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel <i>In vivo</i> Breast Tumor Model

, 2023
James Watters, Chun Cheng, Pradip K. Majumder, Ruojie Wang, Sireesha Yalavarthi, Carol Meeske, Lingxin Kong, Wenping Sun, Jie Lin, Joerg Heyer, Chris Ware, Christopher Winter, John F. Reilly, Tim Demuth, Steve Clark, M. Isabel Chiu, Murray O. Robinson, Nancy E. Kohl, Karuppiah Kannan   +18 more
openalex   +1 more source

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production. [PDF]

Elife
Arafi P, Devkota S, Williams E, Maesako M, Wolfe MS.   +4 more
europepmc   +1 more source

Preferential Regulation of Γ-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease. [PDF]

Adv Sci (Weinh), 2023
Wang X, Zhou R, Sun X, Li J, Wang J, Yue W, Wang L, Liu H, Shi Y, Zhang D.   +9 more
europepmc   +1 more source

Withdrawal: Functional and topological analysis of Pen-2, the fourth subunit of the γ-secretase complex. [PDF]

J Biol Chem, 2023
Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B.   +4 more
europepmc   +1 more source

Presenilin Regulates Insulin Signaling via a γ-Secretase-independent Mechanism

, 2011
Masato Maesako, Kengo Uemura, Akira Kuzuya, Kazuki Sasaki, Megumi Asada, Kiwamu Watanabe, Koichi Andō, Masakazu Kubota, Takeshi Kihara, Ayae Kinoshita   +9 more
openalex   +1 more source

γ-Secretase Inhibitors Enhance Temozolomide Treatment of Human Gliomas by Inhibiting Neurosphere Repopulation and Xenograft Recurrence [PDF]

, 2010
Candace A. Gilbert, Marie‐Claire Daou, Richard P. Moser, Alonzo H. Ross   +3 more
openalex   +1 more source

Neutrophil extracellular traps activate Notch-γ-secretase signaling in hidradenitis suppurativa. [PDF]

J Allergy Clin Immunol
Oliveira CB, Romo-Tena J, Patino-Martinez E, Woo A, Byrd AS, Kim D, Okoye GA, Kaplan MJ, Carmona-Rivera C.   +8 more
europepmc   +1 more source

γ-Secretase Inhibitors Selected by Molecular Docking, to Develop a New Drug Against Alzheimer's Disease. [PDF]

Rep Biochem Mol Biol, 2023
Trasviña-Arenas CH, Ayala Medina LA, Vique-Sánchez JL.   +2 more
europepmc   +1 more source