Results 151 to 160 of about 40,728 (191)

γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds. [PDF]

Alzheimers Res Ther
Trambauer J, Sarmiento RMR, Garringer HJ, Salbaum K, Pedro LD, Crusius D, Vidal R, Ghetti B, Paquet D, Baumann K, Lindemann L, Steiner H.   +11 more
europepmc   +1 more source

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling. [PDF]

Elife
Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MCQ, Franco ML, Özcan B, Gomes Moreira D, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, Chávez-Gutiérrez L.   +15 more
europepmc   +1 more source

Furin, ADAM, and γ-secretase: Core regulatory targets in the Notch pathway and the therapeutic potential for breast cancer. [PDF]

Neoplasia
Yao K, Zhan XY, Feng M, Yang KF, Zhou MS, Jia H.   +5 more
europepmc   +1 more source

Regulation of Mertk Surface Expression via ADAM17 and γ-Secretase Proteolytic Processing. [PDF]

Int J Mol Sci
Lahey KC, Varsanyi C, Wang Z, Aquib A, Gadiyar V, Rodrigues AA, Pulica R, Desind S, Davra V, Calianese DC, Liu D, Cho JH, Kotenko SV, De Lorenzo MS, Birge RB.   +14 more
europepmc   +1 more source

Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP. [PDF]

Front Chem
Netzer WJ, Sinha A, Ghias M, Chang E, Gindinova K, Mui E, Seo JS, Sinha SC.   +7 more
europepmc   +1 more source

Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex. [PDF]

J Biol Chem
Serneels L, Bammens L, Zwijsen A, Tolia A, Chávez-Gutiérrez L, De Strooper B.   +5 more
europepmc   +1 more source

Liraglutide improves cognition function in streptozotocin-induced diabetic rats by downregulating β-secretase and γ-secretase and alleviating oxidative stress in HT-22 cells. [PDF]

Endocr J
Ma LY, Liu SF, Ma ZQ, Guo YG, Li M, Gao Y, Wen YT, Niu Y, Sui HX, Li BS, Li Y, Lv YL, Huang Y, Zhai JJ.   +13 more
europepmc   +1 more source