Results 161 to 170 of about 40,728 (191)

Conformational Changes and Unfolding of β-Amyloid Substrates in the Active Site of γ-Secretase. [PDF]

Int J Mol Sci
Jakowiecki J, Orzeł U, Miszta P, Młynarczyk K, Filipek S.   +4 more
europepmc   +1 more source

Single-cell analysis of the multiple myeloma microenvironment after γ-secretase inhibition and CAR T-cell therapy.

Blood
Coffey DG, Ataca Atilla P, Atilla E, Landgren O, Cowan AJ, Simon S, Pont MJ, Comstock ML, Hill GR, Riddell SR, Green DJ.   +10 more
europepmc   +1 more source

γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome. [PDF]

Ann Neurol
Chen XQ, Becker A, Albay R, Nguyen PD, Karachentsev D, Roberts AJ, Rynearson KD, Tanzi RE, Mobley WC.   +8 more
europepmc   +1 more source

Melatonin Supplementation Alleviates Impaired Spatial Memory by Influencing Aβ_1-42 Metabolism via γ-Secretase in the icvAβ_1-42 Rat Model with Pinealectomy. [PDF]

Int J Mol Sci
Georgieva I, Tchekalarova J, Nenchovska Z, Kortenska L, Tzoneva R.   +4 more
europepmc   +1 more source

Identification of the transmembrane protein 147 (TMEM147) as a novel component of the Nicalin-NOMO membrane protein complex [PDF]

, 2010
Dettmer, Ulf
core  

Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform. [PDF]

Nat Commun
Odorčić I, Hamed MB, Lismont S, Chávez-Gutiérrez L, Efremov RG.   +4 more
europepmc   +1 more source

Retraction notice to "Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model: Involvement of γ-Secretase" [Am J Pathol 178 (2011) 1762-1769]. [PDF]

Am J Pathol
Chu J, Praticò D.
europepmc   +1 more source

Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset acrossPSEN1,PSEN2andAPPcausal genes

Gutiérrez Fernández S, Gan Oria C, Annaert W, Ringman JM, Fox NC, Ryan NS, Chávez-Gutiérrez L.   +6 more
europepmc   +1 more source