Results 131 to 140 of about 40,728 (191)

γ-Secretase in Alzheimer's disease. [PDF]

Exp Mol Med, 2022
Hur JY.
europepmc   +1 more source

Tumour Jagged1 expression as a prognostic marker of bevacizumab response and modulation of 5-fluorouracil efficacy through γ-secretase inhibition in colorectal cancer. [PDF]

Gastroenterol Rep (Oxf)
García-Valdeavero OM, González-Flores E, Ortiz R, Jiménez-López J, Jiménez-Luna C, Caba O, Prados J, Melguizo C.   +7 more
europepmc   +1 more source

Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity. [PDF]

J Neurosci
Du X, Niu L, Ragan M, Fracz Z, Wang ZW.
europepmc   +1 more source

Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors. [PDF]

N Engl J Med, 2023
Gounder M, Ratan R, Alcindor T, Schöffski P, van der Graaf WT, Wilky BA, Riedel RF, Lim A, Smith LM, Moody S, Attia S, Chawla S, D'Amato G, Federman N, Merriam P, Van Tine BA, Vincenzi B, Benson C, Bui NQ, Chugh R, Tinoco G, Charlson J, Dileo P, Hartner L, Lapeire L, Mazzeo F, Palmerini E, Reichardt P, Stacchiotti S, Bailey HH, Burgess MA, Cote GM, Davis LE, Deshpande H, Gelderblom H, Grignani G, Loggers E, Philip T, Pressey JG, Kummar S, Kasper B.   +40 more
europepmc   +1 more source

Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease. [PDF]

Neuron, 2023
Essayan-Perez S, Südhof TC.
europepmc   +1 more source

Membrane lipid remodeling modulates γ-secretase processivity. [PDF]

J Biol Chem, 2023
Dawkins E, Derks RJE, Schifferer M, Trambauer J, Winkler E, Simons M, Paquet D, Giera M, Kamp F, Steiner H.   +9 more
europepmc   +1 more source

Effects of Transmembrane Phenylalanine Residues on γ-Secretase-Mediated Notch-1 Proteolysis. [PDF]

ACS Chem Neurosci
Malvankar SR, Wolfe MS.
europepmc   +1 more source

The human RAP1 and GFAPɛ proteins increase γ-secretase activity in a yeast model system. [PDF]

G3 (Bethesda), 2023
Swanson MJ, Lewis KN, Carpenter R, Whetzel A, Bae NS.   +4 more
europepmc   +1 more source

Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme-Substrate Complex Formation. [PDF]

Biomolecules
Devkota S, Maesako M, Wolfe MS.
europepmc   +1 more source

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production. [PDF]

Elife
Arafi P, Devkota S, Williams E, Maesako M, Wolfe MS.   +4 more
europepmc   +1 more source