Results 11 to 20 of about 29,069 (201)
Molecules, 2021 γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor Protein (APP) and Notch family receptors.
Alicia Ioppolo +4 more
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Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection
Viruses, 2022 Intracellular trafficking of human papillomavirus (HPV) during virus entry requires γ-secretase, a cellular protease consisting of a complex of four cellular transmembrane (TM) proteins. γ-secretase typically cleaves substrate proteins but it plays a non-
Mac Crite, Daniel DiMaio
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Complex regulation of γ-secretase: from obligatory to modulatory subunits [PDF]
Frontiers in Aging Neuroscience, 2015 γ-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid precursor protein (APP), catalyzing the formation of amyloid beta (Aβ) peptides that form amyloid plaques, which contribute to Alzheimer's disease (AD) pathogenesis. γ-Secretase also cleaves Notch, among many other type I transmembrane substrates.
Gertsik, Natalya +2 more
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β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease [PDF]
Frontiers in Aging Neuroscience, 2014 Alzheimer's disease (AD) and vascular dementia are responsible for up to 90% of dementia cases. According to the World Health Organization (WHO), a staggering number of 35.6 million people are currently diagnosed with dementia. Blocking disease progression or preventing AD altogether is desirable for both social and economic reasons and recently focus ...
Menting, K.W., Claassen, J.A.H.R.
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BMC Research Notes, 2021 Objective NGFR/p75NTR and NRADD/NRH proteins are closely related structurally and are encoded by genes that arose from a duplication event early in vertebrate evolution.
Tanya Jayne +3 more
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APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression [PDF]
Frontiers in Aging Neuroscience, 2015 Alzheimer's disease (AD) is characterized by an accumulation of Amyloid-β (Aβ), released by sequential proteolytic processing of the amyloid precursor protein (APP) by β - and γ-secretase. Aβ peptides can aggregate, leading to toxic Aβ oligomers and amyloid plaque formation.
Grimm, Marcus O. W. +12 more
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eLife, 2020 γ-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer’s disease and cancer. While its structure is atomically resolved, γ-secretase localization in the membrane in situ relies mostly on biochemical data.
Abril Angélica Escamilla-Ayala +12 more
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Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. [PDF]
PLoS ONE, 2011 Increase in the generation and deposition of amyloid-β (Aβ) plays a central role in the development of Alzheimer's Disease (AD). Elevation of the activity of γ-secretase, a key enzyme required for the generation for Aβ, can thus be a potential risk ...
Tong Li +5 more
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Turning the tide on Alzheimer’s disease: modulation of γ-secretase
Cell & Bioscience, 2022 Alzheimer’s disease (AD) is the most common type of neurodegenerative disorder. Amyloid-beta (Aβ) plaques are integral to the “amyloid hypothesis,” which states that the accumulation of Aβ peptides triggers a cascade of pathological events leading to ...
Joanna E. Luo, Yue-Ming Li
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γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors
Frontiers in Aging Neuroscience, 2020 Described as the “proteasome of the membrane” or the “scissors in the membrane,” γ-secretase has notoriously complicated biology, and even after decades of research, the full extent of its regulatory mechanism remains unclear.
Eitan Wong +2 more
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