Results 31 to 40 of about 29,069 (201)
Molecules, 2009 Selective lowering of amyloid-β levels with small-molecule γ-secretase inhibitors is a promising therapeutic approach for Alzheimer’s disease. In this work, we developed a high throughput assay for screening of γ-secretase inhibitors with endogenous γ ...
Lie-Feng Wang, Xin Xie, Ru Zhang
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An exo-cell assay for examining real-time γ-secretase activity and inhibition
Molecular Neurodegeneration, 2009 γ-Secretase is an aspartyl protease that cleaves multiple substrates that are involved in broad biological processes ranging from stem cell development to neurodegeneration.
Tian Yuan +3 more
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Neurobiology of Disease, 2007 γ-Secretase is a protease complex, which catalyzes the final of two subsequent cleavages of the β-amyloid precursor protein (APP) to release the amyloid-β peptide (Aβ) implicated in Alzheimer’s disease (AD) pathogenesis.
Keiro Shirotani +4 more
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An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity. [PDF]
PLoS ONE, 2016 γ-secretase mediates the intramembranous proteolysis of amyloid precursor protein (APP) and determines the generation of Aβ which is associated with Alzheimer's disease (AD). Here we identified that an anti-Parkinson's disease drug, Istradefylline, could
Jing Lu +8 more
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Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates
Molecular Neurodegeneration, 2006 Background The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been shown to mediate a variety of ...
Nyborg Andrew C +4 more
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Visualization of PS/γ-Secretase Activity in Living Cells
iScience, 2020 Summary: A change in Presenilin (PS)/γ-secretase activity is linked to essential biological events as well as to the progression of many diseases. However, not much is known about how PS/γ-secretase activity is spatiotemporally regulated in cells. One of
Masato Maesako +5 more
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Modulators of γ-secretase activity can facilitate the toxic side-effects and pathogenesis of Alzheimer's disease. [PDF]
PLoS ONE, 2013 BACKGROUND: Selective modulation of different Aβ products of an intramembrane protease γ-secretase, could be the most promising strategy for development of effective therapies for Alzheimer's disease.
Željko M Svedružić +2 more
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Advanced Science, EarlyView.Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian +5 more
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Inhibition of γ-secretase in adipocytes leads to altered IL-6 secretion and adipose inflammation
Adipocyte, 2020 Adipocyte-mediated inflammatory signalling has been proposed to alter adipose physiology in obesity and Type 2 diabetes mellitus. Novel targets for alteration of inflammatory signalling are needed to improve obesity-related outcomes.
David P. Sparling +3 more
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Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells
Sensors, 2023 Our unique multiplexed imaging assays employing FRET biosensors have previously detected that γ-secretase processes APP C99 primarily in late endosomes and lysosomes in live/intact neurons. Moreover we have shown that Aβ peptides are enriched in the same
Mei C. Q. Houser +5 more
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