Results 51 to 60 of about 29,069 (201)
Food Biomacromolecules, EarlyView.Abstract As one of the most important components of foods, animal meat provides a lot of protein, fat, and energy for humans. However, nutrition and health of animals directly affect the healthiness of human, especially antibiotic residues in animals induced by abuse of antibiotics.
Zichao Wang +8 more
wiley +1 more source
Γ-secretase components as predictors of breast cancer outcome.
PLoS ONE, 2013 γ-secretase is a large ubiquitously expressed protease complex composed of four core subunits: presenilin, Aph1, PEN-2, and nicastrin. The function of γ-secretase in the cells is to proteolytically cleave various proteins within their transmembrane ...
Hanna M Peltonen +5 more
doaj +1 more source
Presenilin is the molecular target of acidic γ-secretase modulators in living cells. [PDF]
PLoS ONE, 2012 The intramembrane-cleaving protease γ-secretase catalyzes the last step in the generation of toxic amyloid-β (Aβ) peptides and is a principal therapeutic target in Alzheimer's disease.
Thorsten Jumpertz +6 more
doaj +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This graphical abstract illustrates the experimental design and key findings of the study on the role of mesenchymal stem cells (MSCs) and Notch signaling in diabetic foot ulcer (DFU) healing. The study involved five groups of BALB/c mice: Control, Model, MSCs Treatment, MSCs + Notch Inhibition, and MSCs + Notch Activation.
Feifei Li +6 more
wiley +1 more source
PLoS ONE, 2014 Alzheimer's disease (AD) is the most prevalent form of dementia affecting the elderly. Neurodegeneration is caused by the amyloid beta (Aβ) peptide which is generated from the sequential proteolytic cleavage of the Amyloid Precursor Protein (APP) by the ...
Katarina Jovanovic +4 more
doaj +1 more source
Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders
Neuroprotection, EarlyView.The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan +5 more
wiley +1 more source
Laboratory Animal Research, 2016 Alzheimer’s disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the effects of human Presenilin 2 mutant (hPS2m) overexpression
Woo Bin Yun +7 more
doaj +1 more source
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity
EMBO Molecular Medicine, 2022 Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also linked to chronic diseases. Despite its physiological and medical importance, the regulation of Fn14 signaling and turnover is only partly understood.
Gökhan Güner +17 more
doaj +1 more source
Contemporary Management of Malignancies of the Parotid Gland: A State‐of‐the‐Art Review
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objectives To provide a systematic update on the contemporary management of malignancies of the parotid gland (MPG), focusing on evidence‐based practices and emerging therapeutics. Data Sources PubMed literature search. Review Methods A search protocol was designed according to the Preferred Reporting Items for Systematic Reviews and Meta ...
Anthony Tang +10 more
wiley +1 more source