Results 51 to 60 of about 62,533 (281)

Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms [PDF]

, 2014
Background: Muntingia calabura (Elaecoparceae) is a medicinal plant traditionally used, particularly, by the Peruvian people to alleviate headache and cold, pain associated with gastric ulcers or to reduce the prostate gland swelling.
Abdul Kader, Arifah, Cheema, Manraj Singh, Mohd Sani, Mohd Hijaz, Salleh, Mohd Zaki, Teh, Lay Kek, Zakaria, Zainul Amiruddin   +5 more
core   +1 more source

Herbal highs: review on psychoactive effects and neuropharmacology [PDF]

, 2017
Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances.
Graziano, S, Orsolini, L, Pichini, S., Rotolo, Mc, Schifano, F, Tittarelli, R   +5 more
core   +1 more source

Bidirectional Regulation of Opioid and Chemokine Function

Frontiers in Immunology, 2020
The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
doaj   +1 more source

Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics

Molecular Neurobiology, 2018
Molecular changes induced by excessive alcohol consumption may underlie formation of dysphoric state during acute and protracted alcohol withdrawal which leads to craving and relapse.
I. Bazov, D. Sarkisyan, O. Kononenko, H. Watanabe, T. Yakovleva, A. Hansson, W. Sommer, R. Spanagel, G. Bakalkin   +8 more
semanticscholar   +1 more source

Computational Methods for Understanding the Selectivity and Signal Transduction Mechanism of Aminomethyl Tetrahydronaphthalene to Opioid Receptors

Molecules, 2022
Opioid receptors are members of the group of G protein-couple receptors, which have been proven to be effective targets for treating severe pain. The interactions between the opioid receptors and corresponding ligands and the receptor’s activation by ...
Peng Xie, Junjie Zhang, Baiyu Chen, Xinwei Li, Wenbo Zhang, Mengdan Zhu, Wei Li, Jianqi Li, Wei Fu   +8 more
doaj   +1 more source

Targeting opioid receptor signaling in depression: do we need selective κ opioid receptor antagonists?

Neuronal Signaling, 2018
The opioid receptors are a family of G-protein coupled receptors (GPCRs) with close structural homology. The opioid receptors are activated by a variety of endogenous opioid neuropeptides, principally β-endorphin, dynorphins, leu- and met-enkephalins ...
S. Bailey, S. Husbands
semanticscholar   +1 more source

7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects [PDF]

, 2019
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Ansonoff, Michael, Gassaway, Madalee M., Grinnell, Steven G., Javitch, Jonathan A., Kruegel, Andrew C., Langreck, Cory, Le Rouzic, Valerie, Majumdar, Susruta, Pasternak, Gavril W., Pekarskaya, Elizabeth A., Pintar, John E., Sames, Dalibor, Uprety, Rajendra   +12 more
core   +3 more sources

Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implicationsCapsule Summary

JAAD International, 2022
Introduction: Treating chronic pruritus is challenging for dermatologists due to the lack of therapeutic options. We review the effects of κ-opioid receptor (KOR) and μ-opioid receptor (MOR) in the modulation of itch, summarize evidence supporting the ...
Sarina Elmariah, MD, PhD, Sarah Chisolm, MD, Thomas Sciascia, MD, Shawn G. Kwatra, MD   +3 more
doaj   +1 more source

Effects of ATPM-ET, a novel κ agonist with partial μ activity, on physical dependence and behavior sensitization in mice [PDF]

, 2014
Aim: To investigate the effects of ATPM-ET [(−)-3-N-Ethylaminothiazolo [5,4-b]-N-cyclopropylmethylmorphinan hydrochloride] on physical dependence and behavioral sensitization to morphine in mice.
Chen, Jie, Cheng, Yun, Chi, Zhi-qiang, Li, Fu-ying, Liu, Jing-gen, Lu, Gang, Neumeyer, John L, Sun, Jian-feng, Tao, Yi-min, Wang, Yu-hua, Xu, Xue-jun, Zhang, Ao   +11 more
core   +1 more source

The G‐protein biased partial κ opioid receptor agonist 6′‐GNTI blocks hippocampal paroxysmal discharges without inducing aversion

British Journal of Pharmacology, 2016
With a prevalence of 1–2%, epilepsies belong to the most frequent neurological diseases worldwide. Although antiepileptic drugs are available since several decades, the incidence of patients that are refractory to medication is still over 30 ...
L. Zangrandi, J. Burtscher, James P. Mackay, W. Colmers, C. Schwarzer   +4 more
semanticscholar   +1 more source