Results 1 to 10 of about 19,726 (227)

Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference [PDF]

Cell Reports, 2019
Summary: The underlying mechanisms of how positive emotional valence (e.g., pleasure) causes preference of an associated context is poorly understood. Here, we show that activation of astrocytic μ-opioid receptor (MOR) drives conditioned place preference
Min-Ho Nam, Kyung-Seok Han, Jaekwang Lee, Woojin Won, Wuhyun Koh, Jin Young Bae, Junsung Woo, Jayoung Kim, Elliot Kwong, Tae-Yong Choi, Heejung Chun, Seung Eun Lee, Sang-Bum Kim, Ki Duk Park, Se-Young Choi, Yong Chul Bae, C. Justin Lee   +16 more
doaj   +2 more sources

The μ-opioid receptor differentiates two distinct human nociceptive populations relevant to clinical pain [PDF]

Cell Reports Medicine
Summary: The shortfall in new analgesic agents is a major impediment to reducing reliance on opioid medications for control of severe pain. In both animals and man, attenuating nociceptive transmission from primary afferent neurons with a μ-opioid ...
Ellen S. Staedtler, Matthew R. Sapio, Diana M. King, Dragan Maric, Andre Ghetti, Andrew J. Mannes, Michael J. Iadarola   +6 more
doaj   +2 more sources

CtBP1 is essential for epigenetic silencing of μ-opioid receptor genes in the dorsal root ganglion in spinal nerve ligation-induced neuropathic pain [PDF]

Neurotherapeutics
Neuropathic pain poses a significant public health challenge, greatly impacting patients' quality of life. Emerging evidence underscores the involvement of epigenetics in dorsal root ganglion (DRG) neurons relevant to pain modulation.
Cheng-Yuan Lai, Ming-Chun Hsieh, Chou-Ming Yeh, Tzer-Bin Lin, Dylan Chou, Hsueh-Hsiao Wang, Kuan-Hung Lin, Jen-Kun Cheng, Po-Sheng Yang, Hsien-Yu Peng   +9 more
doaj   +2 more sources

Activation of μ-opioid receptors inhibits calcium-currents in the vestibular afferent neurons of the rat through a cAMP dependent mechanism [PDF]

Frontiers in Cellular Neuroscience, 2014
Opioid receptors are expressed in the vestibular endorgans (afferent neurons and hair cells) and are activated by the efferent system, which modulates the discharge of action potentials in vestibular afferent neurons (VANs). In mammals, VANs mainly express the μ opioid-receptor, but the function of this receptors activation and the cellular mechanisms ...
Seseña, Emmanuel, Vega, Rosario, Soto, Enrique   +2 more
openaire   +2 more sources

Connections between EM2-containing terminals and GABA/μ-opioid receptor co-expressing neurons in the rat spinal trigeminal caudal nucleus [PDF]

Frontiers in Neural Circuits, 2014
Endomorphin-2 (EM2) demonstrates a potent antinociceptive effect via the μ-opioid receptor (MOR). To provide morphological evidence for the pain control effect of EM2, the synaptic connections between EM2-immunoreactive (IR) axonal terminals and γ-amino butyric acid (GABA)/MOR co-expressing neurons in lamina II of the spinal trigeminal caudal nucleus ...
Li, Meng-Ying, Wu, Zhen-Yu, Lu, Ya-Cheng, Yin, Jun-Bin, Wang, Jian, Zhang, Ting, Dong, Yu-Lin, Wang, Feng   +7 more
openaire   +2 more sources

<p>ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The μ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy</p> [PDF]

Journal of Pain Research, 2019
Pain management with conventional opioids can be challenging due to dose-limiting adverse events (AEs), some of which may be related to the simultaneous activation of β-arrestin (a signaling pathway associated with opioid-related AEs) and G-protein pathways.
Sergio D Bergese, Marek Brzezinski, Gregory B Hammer, Timothy L Beard, Peter H Pan, Sharon E Mace, Richard D Berkowitz, Kristina Cochrane, Linda Wase, Harold S Minkowitz, Ashraf Habib   +10 more
openaire   +5 more sources

μ-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal μ-receptor immunoreactivity at the injured nerve trunk in mice. [PDF]

PLoS ONE, 2013
Neuropathic pain is a debilitating chronic disease often resulting from damage to peripheral nerves. Activation of opioid receptors on peripheral sensory neurons can attenuate pain without central nervous system side effects. Here we aimed to analyze the
Yvonne Schmidt, Claire Gavériaux-Ruff, Halina Machelska   +2 more
doaj   +1 more source

Biased Opioid Antagonists as Modulators of Opioid Dependence: Opportunities to Improve Pain Therapy and Opioid Use Management

Molecules, 2020
Opioid analgesics are effective pain therapeutics but they cause various adverse effects and addiction. For safer pain therapy, biased opioid agonists selectively target distinct μ opioid receptor (MOR) conformations, while the potential of biased opioid
Wolfgang Sadee, John Oberdick, Zaijie Wang   +2 more
doaj   +1 more source

Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction

Molecules, 2022
Numerous G-protein-coupled receptors (GPCRs) display ligand-free basal signaling with potential physiological functions, a target in drug development.
Wolfgang Sadee, John C. McKew
doaj   +1 more source

Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment. [PDF]

PLoS ONE, 2014
Opioids, acting at μ opioid receptors, are commonly used for pain management. Chronic opioid treatment induces cellular adaptations, which trigger long-term side effects, including constipation mediated by enteric neurons.
Celine Duraffourd, Erica Kumala, Laura Anselmi, Nicholas C Brecha, Catia Sternini   +4 more
doaj   +1 more source