Results 121 to 130 of about 31,247 (253)
Brain and Behavior, Volume 15, Issue 11, November 2025.Our morphological brain network analysis of 82 participants reveals that these substances leave dramatically different fingerprints that persist even in recovery, with heroin causing global network collapse through increased path lengths across the entire cortex, while methamphetamine selectively damages temporal parietal, and visual processing centers.
Xiaoliang Zhou +3 more
wiley +1 more source
Human Brain Mapping, Volume 46, Issue 16, November 2025.MIND‐based clustering identified two MDD subtypes with distinct molecular signatures. ABSTRACT Major depressive disorder (MDD) exhibits substantial neurobiological heterogeneity that complicates treatment selection and mechanistic understanding. While conventional group‐level analyses identify diverse structural alterations, they obscure clinically ...
Yao Ge +7 more
wiley +1 more source
Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor [PDF]
, 2020 Alexander Gillis +6 more
openalex +1 more source
The Journal of Clinical Pharmacology, Volume 65, Issue 11, Page 1577-1586, November 2025.Abstract Impaired awareness of hypoglycemia (IAH) impacts 25%‐30% of individuals with type 1 diabetes mellitus (T1D), potentially leading to severe outcomes due to reduced symptom perception. Naloxone, a mu‐opioid receptor antagonist, shows promise as a preventive measure against IAH.
Omar N. Al Yacoub +9 more
wiley +1 more source
Pain Perception: Investigating Links Between Pain Transmission and CCK(+) Neurons, with Regard to the Opioid Crisis [PDF]
, 2017 With dependence on opioids, such as codeine, morphine, and heroin, steadily increasing amongst the American public, the withdrawal symptoms associated with disuse are receiving much more attention.
Panesar, Sumeet, Tepper, Zachary
core +2 more sources
Antiobesity Medications for Older Adults—the New, the Good, the Bad, and the Unknown
Obesity, Volume 33, Issue S1, Page 57-73, November 2025.ABSTRACT Objective Obesity affects 42% of older adults, with rates continuing to rise. This a complex condition influenced by non‐modifiable as well as modifiable risk factors. The disease can be treated through modifications to diet, physical activity, and behavior and more recently through antiobesity medications (AOMs) and surgery. Treatment must be
Anna Pendrey, Javier Sevilla‐Martir
wiley +1 more source
DAMGO, a μ‐opioid receptor selective ligand, distinguishes between μ‐and κ‐opioid receptors at a different region from that for the distinction between μ‐ and δ‐opioid receptors [PDF]
, 1995 Masabumi Minami +6 more
openalex +1 more source
Aging Cell, Volume 24, Issue 11, November 2025.Postnatal high fat (HF) feeding negatively impacts executive function in both adult and aged mice, but consumption of the same diet during the perinatal period only is beneficial in older age. Maternal HF diet is associated with increased cholinergic innervation of the prefrontal cortex of young, but not aged, offspring.
Laura Contu +3 more
wiley +1 more source
Effects of opioids on ventilation and hemodynamics [PDF]
, 2007 Opioids are most commonly used for treatment of severe pain. However, the fear of respiratory depression has restricted the use of opioids. Depending on the monitoring system used, different modes of opioid respiratory effects have been noted in previous
Mildh, Leena
core
Naloxone dosing in the era of synthetic opioids: Applying the Goldilocks principle
Addiction, Volume 120, Issue 11, Page 2165-2172, November 2025.Abstract The opioid overdose epidemic remains a critical public health crisis. In recent years, synthetic opioids like fentanyl and nitazenes, have driven a sharp rise in deaths. Naloxone, an opioid receptor antagonist, has been established as a key intervention for reversing opioid overdoses and saving lives.
Mariana Gonzalez Utrilla +8 more
wiley +1 more source