Results 131 to 140 of about 28,832 (208)

Naldemedine for the Prevention of Recurrent Acute Pancreatitis: A Randomised, Double‐Blind, Placebo‐Controlled Trial

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background and aims No medications are currently approved for the prevention of recurrent acute pancreatitis. This trial evaluated whether naldemedine, a peripherally acting μ‐opioid receptor antagonist, reduces the risk of acute pancreatitis in patients with recurrent acute pancreatitis. Methods This was a multicentre, double‐blinded, placebo‐
Mathias E. Cook, Cecilie S. Knoph, Line Davidsen, Jens B. Frøkjær, Niels H. Bruun, Srdan Novovic, Amer Hadi, Maiken Thyregod Jørgensen, Michael B. Mortensen, Ove Schaffalitzky, Liv B. J. Nielsen, Mark Berner‐Hansen, Asbjørn M. Drewes, Søren S. Olesen   +13 more
wiley   +1 more source

Effective management of chronic lumbar back pain in five dogs using an erector spinae plane block

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract This retrospective case series evaluates the use of the ultrasound‐guided erector spinae plane block for managing chronic lumbar pain in five dogs unresponsive to conventional systemic analgesia. Each patient received a bilateral erector spinae plane block at either the L2/L3 or L3/L4 level under general anaesthesia. The injectate consisted of
Nathalie Haslinger, Katrin Ertelt
wiley   +1 more source

Brain region–specific neural activation by low-dose opioid promotes social behavior

JCI Insight
The opioid system plays crucial roles in modulating social behaviors in both humans and animals. However, the pharmacological profiles of opioids regarding social behavior and their therapeutic potential remain unclear.
Soichiro Ohnami, Megumi Naito, Haruki Kawase, Momoko Higuchi, Shigeru Hasebe, Keiko Takasu, Ryo Kanemaru, Yuki Azuma, Rei Yokoyama, Takahiro Kochi, Eiji Imado, Takeru Tahara, Yaichiro Kotake, Satoshi Asano, Naoya Oishi, Kazuhiro Takuma, Hitoshi Hashimoto, Koichi Ogawa, Atsushi Nakamura, Hidekuni Yamakawa, Yukio Ago   +20 more
doaj   +1 more source

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran

Basic and Clinical Neuroscience, 2018
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence.
Sara Soleimani Asl, Amir Roointan, Hugo Bergen, Shayan Amiri, Parastoo Mardani, Niloufar Ashtari, Ronak Shabani, Mehdi Mehdizadeh   +7 more
doaj  

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

British Journal of Pharmacology, Volume 183, Issue 3, Page 505-519, February 2026.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj, Saadet Inan, Guo‐Hua Bi, Sonita Wiah, George Adamson, Allen B. Reitz, Zheng‐Xiong Xi, Scott M. Rawls   +7 more
wiley   +1 more source

Update of the statement on safety of cannabidiol as a novel food

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract During the assessment of cannabidiol (CBD) as a novel food, in 2022 the NDA Panel identified significant data gaps. Concerns focused on potential adverse effects on the liver, gastrointestinal tract, endocrine, nervous and reproductive systems.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Francesco Cubadda, Helle Katrine Knutsen, Harry J. McArdle, Peter Moldeus, Monika Neuhäuser‐Berthold, Josef Rudolf Schlatter, Alexandros Siskos, Viviana Trezza, Océane Albert, Elisa Beneventi, Irene Nuin Garciarena, George E. N. Kass, Marcello Laganaro, Annamaria Rossi, Alejandra Muñoz, Areti Favata, Anna Maria Pieger, Maura Magani, Karen Ildico Hirsch‐Ernst   +33 more
wiley   +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

Expanding Access to Dental Care for Patients on Suboxone [PDF]

, 2017
Those using Suboxone® for medication-assisted treatment for opioid dependence are at increased risk for poor oral health for a variety of reasons including lifestyle factors, effects of opioids and the direct impact of Suboxone® on the oral environment ...
White, Nathan E
core   +1 more source

Carfentanil is a β-arrestin-biased agonist at the μ opioid receptor. [PDF]

Br J Pharmacol, 2023
Ramos-Gonzalez N, Groom S, Sutcliffe KJ, Bancroft S, Bailey CP, Sessions RB, Henderson G, Kelly E.   +7 more
europepmc   +1 more source

The molecular basis of μ-opioid receptor signaling plasticity. [PDF]

Cell Res
Zhang H, Wang X, Xi K, Shen Q, Xue J, Zhu Y, Zang SK, Yu T, Shen DD, Guo J, Chen LN, Ji SY, Qin J, Dong Y, Zhao M, Yang M, Wu H, Yang G, Zhang Y.   +18 more
europepmc   +1 more source