Results 131 to 140 of about 31,247 (253)
Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran
Basic and Clinical Neuroscience, 2018 Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence.
Sara Soleimani Asl +7 more
doaj
Effects of Ginseng Total Saponin on [3H]DAGO Bindings of Opioid μ-Receptors [PDF]
, 2002 Ki‐Wan Oh +4 more
openalex +1 more source
Fentanyl Disrupts Vagal Control of Airway Tone to Induce Transient Obstruction
Acta Physiologica, Volume 241, Issue 11, November 2025.ABSTRACT Aim Opioid‐induced respiratory depression (OIRD) is the primary cause of death in opioid overdose, resulting from both suppressed respiratory rhythm and increased airway and thoracic rigidity that compromise ventilation and resuscitation. While the effect(s) of opioids on central rhythm‐generating circuits are well documented, the mechanisms ...
Riley R. Parks +3 more
wiley +1 more source
Brain region–specific neural activation by low-dose opioid promotes social behavior
JCI InsightThe opioid system plays crucial roles in modulating social behaviors in both humans and animals. However, the pharmacological profiles of opioids regarding social behavior and their therapeutic potential remain unclear.
Soichiro Ohnami +20 more
doaj +1 more source
Activation of the μ‐opioid receptor by alicyclic fentanyls: Changes from high potency full agonists to low potency partial agonists with increasing alicyclic substructure [PDF]
, 2020 Anna Åstrand +5 more
openalex +1 more source
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential
British Journal of Pharmacology, Volume 182, Issue 21, Page 5090-5118, November 2025.Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley +1 more source
Binding Pathways of a G-Protein Biased μ-opioid Receptor agonist under Clinical Evaluation [PDF]
, 2016 Sebastian Schneider +2 more
openalex +1 more source
Brain Network Signature of Autoscopic Phenomena in Humans
CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.This study identified a common brain network underlying AP, encompassing bilateral angular gyrus, posterior medial cortex, intraparietal sulcus, cuneus, fusiform and insula, and uncovered its multimodal signatures. These findings advance our understanding of the network mechanisms of AP, as well as provide novel insights into bodily self‐consciousness.
Siyi Wang +8 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 27, Issue 11, Page 6105-6115, November 2025.Abstract Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are highly effective antidiabetic and anti‐obesity agents. Recent development and optimisation of these agents includes biased agonism (selective activation of a downstream signalling pathway) of the GLP‐1 receptor, which has demonstrated greater weight‐lowering effects and improved insulin
Sabrina Wong +4 more
wiley +1 more source