CtBP1 is essential for epigenetic silencing of μ-opioid receptor genes in the dorsal root ganglion in spinal nerve ligation-induced neuropathic pain [PDF]
NeurotherapeuticsNeuropathic pain poses a significant public health challenge, greatly impacting patients' quality of life. Emerging evidence underscores the involvement of epigenetics in dorsal root ganglion (DRG) neurons relevant to pain modulation.
Cheng-Yuan Lai +9 more
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µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice [PDF]
Translational PsychiatryMood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid peptides, are important for emotion regulation.
Khalin E. Nisbett +2 more
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Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction. [PDF]
, 2016 BACKGROUND: A difficult problem in treating opioid addicts is the maintenance of a drug-free state because of the negative emotional symptoms associated with withdrawal, which may trigger relapse.
Bailey, A +8 more
core +1 more source
Pharmacological Profiles of Oligomerized μ-Opioid Receptors
Cells, 2013 Opioids are widely prescribed pain relievers with multiple side effects and potential complications. They produce analgesia via G-protein-protein coupled receptors: μ-, δ-, κ-opioid and opioid receptor-like 1 receptors.
Ing-Kang Ho, Cynthia Wei-Sheng Lee
doaj +1 more source
How μ-opioid receptor recognizes fentanyl
Nature Communications, 2021 Structures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear.
Quynh N. Vo +3 more
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Frontiers in Medicine, 2022 BackgroundMyoclonic movement is a very common but undesirable phenomenon during the induction of general anesthesia using etomidate. Such movement may cause unnecessary problems.
Kang-Da Zhang +5 more
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Modulation of Neurally Mediated Vasodepression and Bradycardia by Electroacupuncture through Opioids in Nucleus Tractus Solitarius. [PDF]
, 2018 Stimulation of vagal afferent endings with intravenous phenylbiguanide (PBG) causes both bradycardia and vasodepression, simulating neurally mediated syncope.
Fu, Liang-Wu +3 more
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Recent Molecular Insights into Agonist-specific Binding to the Mu-Opioid Receptor
Frontiers in Molecular Biosciences, 2022 Opioid agonists produce their analgesic effects primarily by acting at the µ-opioid receptor (µOR). µOR agonists with different efficacies exert diverse molecular changes in the µOR which dictate the faith of the receptor’s signaling pathway and possibly
Ferenc Zádor +3 more
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Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects [PDF]
, 2019 Opioid analgesics are powerful pain relievers; however, over time, pain control diminishes as analgesic tolerance develops. The molecular mechanisms initiating tolerance have remained unresolved to date.
Bailey, A +8 more
core +2 more sources
Methamphetamine-induced changes in the striatal dopamine pathway in μ-opioid receptor knockout mice
Journal of Biomedical Science, 2011 Background Repeated exposure to methamphetamine (METH) can cause not only neurotoxicity but also addiction. Behavioral sensitization is widely used as an animal model for the study of drug addiction.
Park Sang Won +4 more
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