Results 81 to 90 of about 31,247 (253)

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Establishment of Opioid-Induced Rewarding Effects Under Oxaliplatin-and Paclitaxel-Induced Neuropathy in Rats

Journal of Pharmacological Sciences, 2014
The rewarding effects of μ-receptor agonists can be suppressed under several pain conditions. We recently showed that clinically used μ-receptor agonists possess efficacies for relieving the neuropathic pain induced by chemotherapeutic drug in rats ...
Tomohisa Mori, Tomoe Kanbara, Masato Harumiya, Yoshiyuki Iwase, Aki Masumoto, Sachiko Komiya, Atsushi Nakamura, Masahiro Shibasaki, Toshiyuki Kanemasa, Gaku Sakaguchi, Tsutomu Suzuki   +10 more
doaj   +1 more source

Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer

Radiology and Oncology, 2023
Tramadol is an opioid analgesic often used for pain management after breast cancer surgery. Its analgesic activity is due to the activation of the μ-opioid receptor, encoded by the OPRM1 gene.
Vidic Zala, Goricar Katja, Strazisar Branka, Besic Nikola, Dolzan Vita   +4 more
doaj   +1 more source

The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist [PDF]

, 2020
The kappa opioid receptor (κOR) is an important target for pain therapeutics to reduce depression and other harmful side effects of existing medications.
Goddard, William A., III, Kim, Soo-Kyung, Mafi, Amirhossein   +2 more
core   +1 more source

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

British Journal of Pharmacology, EarlyView.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj, Saadet Inan, Guo‐Hua Bi, Sonita Wiah, George Adamson, Allen B. Reitz, Zheng‐Xiong Xi, Scott M. Rawls   +7 more
wiley   +1 more source

Bidirectional Regulation of Opioid and Chemokine Function

Frontiers in Immunology, 2020
The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
doaj   +1 more source

The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking. [PDF]

, 2015
Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction.
Belin, David, Bullmore, Edward T., Economidou, Daina, Everitt, Barry J., Garc?a-Pardo, Maria P., Giuliano, Chiara, Goodlett, Charles R., Robbins, Trevor W.   +7 more
core   +4 more sources

Frozen in Addiction: A New Wave of Drug‐Induced Movement Disorders?

Movement Disorders, EarlyView.
Christos Ganos, Roberto Erro, Mohammad Abdullah, Tanya S. Hauck, Daniel Ciccarone, Christy Sutherland, Parisa Saiyarsarai, Connie Marras, Susan H. Fox, Alfonso Fasano, Anthony E. Lang, Jonathan Squires, Kailash P. Bhatia   +12 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Methadone ameliorates multiple-low-dose streptozotocin-induced type 1 diabetes in mice [PDF]

Type 1 diabetes is an autoimmune disease characterized by inflammation of pancreatic islets and destruction of β cells by the immune system. Opioids have been shown to modulate a number of immune functions, including T helper 1 (Th1) and T helper 2 ...
امیرشاهرخی, کیوان, حاجتی, جمشيد, دهپور, احمدرضا, ستوده, مسعود, قاضی خوانساری, محمود   +4 more
core   +1 more source