Results 31 to 40 of about 14,254 (195)
Zhongshan Daxue xuebao. Yixue kexue ban, 2023 自然杀伤（NK）细胞是T细胞后具有临床应用前景的另一类抗肿瘤免疫细胞。NK 细胞的活性主要受其表面受体和免疫微环境的调控，胶质瘤较强的免疫抑制性肿瘤微环境使NK细胞免疫治疗效率较低。本综述从胶质瘤-NK细胞交互作用角度讨论NK细胞在脑胶质瘤免疫治疗中作用的最新研究进展，总结靶向NK 细胞的化合物、单克隆抗体和细胞因子疗法，重点讨论了基因修饰的NK细胞在胶质瘤免疫治疗的现状及趋势，以及胶质瘤细胞的相关免疫逃逸分子机制，为基于NK细胞的免疫治疗神经胶质瘤提供理论依据和新的思路。
孙士隆, 陈保东
doaj
Clinical implication of PD-L2 in the prognosis assessment of HNSCC immunotherapy [PDF]
, 2023 Background and purpose: Programmed death-1 (PD-1) monoclonal antibody therapy plays an increasingly important role in the treatment of head and neck squamous cell carcinoma (HNSCC).
HUANG He, JU Houyu, YANG Wenyi, YAN Ming, REN Guoxin, HU Jingzhou
core +1 more source
Research progress of MDSCs-targeted immunotherapy for pancreatic cancer [PDF]
, 2023 Pancreatic cancer (PC) is a highly malignant digestive system tumor with a poor survival rate and prognosis. Most patients with pancreatic cancer have no obvious clinical manifestations in the early stage of the disease, and are found to be in the middle
PENG Meiyu +4 more
core +1 more source
The latest progress of breast cancer treatment at 2023 ESMO [PDF]
, 2023 At 2023 Annual Meeting of European Society of Medical Oncology (ESMO), Several latest research achievements in the field of breast cancer were announced.
ZHOU Teng, ZHANG Jian
core +1 more source
Advancements in the research of immunomodulatory effects of radiation therapy: from basic to clinical [PDF]
, 2023 Previously, radiotherapy was considered to directly kill tumor cells by deoxyribonucleic acid double-strand break. Recent studies have found that radiotherapy can also produce positive and effective anti-tumor effect by upregulating local and systemic ...
WANG Yu, BI Nan
core +1 more source
亚洲临床医学杂志, 2020 胆管癌（cholangiocarcinoma）是一种侵袭性恶性肿瘤，发生率较低，但其恶性程度高，且治疗方案有限，预后差，所以需要新的治疗方法。近年来，免疫治疗已成为肿瘤领域的研究热点，它利用患者原有的免疫系统靶向杀伤肿瘤细胞，这种治疗方法在恶性黑色素瘤和晚期非小细胞肺癌中已经取得了令人欣喜的治疗效果。中国和国际上对于胆管癌免疫治疗的新方法也正在进行积极的探索，部分研究在早期实验中也取得了积极的结果。因此，免疫治疗在胆管癌中的应用价值得到了初步证实，值得进一步研究。目前 ...
秀洋 曹, 大旭 彭
semanticscholar +1 more source
Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases
Rare Metals, EarlyView.ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan +5 more
wiley +1 more source
The Expression and Biological Significance of PD-L1 on Lung Cancer Cell Lines [PDF]
, 2009 Background and objective Tumor-associated PD-L1 expression was recently shown to promote T-cell apoptosis and proposed as a potential mechanism of immune evasion by tumors. On the basis of the ability of tumor-associated PD-L1 to mediate activated T-cell
Cheng CHEN +6 more
core
New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics
Rare Metals, EarlyView.ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu +8 more
wiley +1 more source
Construction of CpG-Au@HBc virus like particles and study of their membrane translocation mechanism, immunostimulary effect [PDF]
, 2016 乙肝病毒核心蛋白病毒样颗粒（HepatitisvirusBviruscoreproteinviruslikeparticles，HBcVLPs）因其不具有乙肝病毒的复制能力而又具备较强的免疫原性而被广泛应用于构建新型疫苗。另一方面，HBcVLPs的正二十面体空腔结构和解聚/自组装特性使得其还能够作为纳米载体呈递基因、纳米粒子等。本课题利用HBcVLPsC末端的富集正电荷序列可以通过静电吸引力与核酸相互作用的特点，构建了一种同时包裹有CpG寡核苷酸链（CpGODNs）佐剂和金纳米粒子的HBcVLPs ...
王雅润
core