Results 41 to 50 of about 14,254 (195)
Rare Metals, EarlyView.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Nursing of a patient with Sintilimab-induced autoimmune myocarditis (1例信迪利单抗治疗后出现免疫性心肌炎患者的护理)
中西医结合护理, 2023 This paper summarized the nursing management for a patient with autoimmune myocarditis after 2 courses of Sintilimab. The patient received hormonotherapy, immunoregulation and other drug treatment.
HUANG Wenyi (黄雯薏) +4 more
doaj +1 more source
Preparation of monoclonal antibodies against mouse alpha-fetoprotein and preliminary study on their application [PDF]
, 2016 原发性肝癌是我国高发的恶性肿瘤之一，每年新发和死亡患者均占全球总数的一半以上。根据全国肿瘤登记中心最新公布的2015年《肿瘤登记年报》数据，我国肝癌新增病例为46.61万，占所有恶性肿瘤的第4位（10.86%），而死亡病例为42.21万，占所有癌症死亡的第3位（15.00%），仅次于肺癌和胃癌。尽管近年来肝癌的诊断和治疗有了一定的进展，其预后仍然不理想，五年生存率极低。究其原因，大部分肝癌患者往往在疾病的晚期才被诊断出来，有些甚至发生了远端转移，因而错过了最佳治疗时机；此外 ...
潘海娇
core
Recent Advances and Hot Spots of Neoadjuvant Immunotherapy Combined with Chemotherapy for Esophageal Carcinoma [PDF]
Surgery-based multidisciplinary comprehensive treatment is the preferred treatment strategy for local advanced esophageal cancer. Neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy have been recommended by the Chinese Society of Clinical Oncology
Chunyue GAI +8 more
core +1 more source
Current status and treatment direction of the immune microenvironment of castration-resistant prostate cancer [PDF]
, 2023 With the rapid development of cancer immunology, more and more research focuses on the role of immune cells and signaling molecules in the tumor microenvironment. Prostate cancer is the second most common malignant tumor in men globally.
YANG Wenbo, ZHANG Bin, WU Jiahui, CUI Jie
core +1 more source
Veterinary Dermatology, EarlyView.Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes +8 more
wiley +1 more source
Advances in Research on Lactate Metabolism Disorders and Their Effect on Immunotherapy in Lung Adenocarcinoma [PDF]
Recent studies have identified that metabolic reprogramming in lung adenocarcinoma cells, particularly lactate metabolism disorders, plays a crucial role in tumor development and immune therapy response.
Cixiang CHEN +6 more
core +1 more source
Veterinary Dermatology, EarlyView.Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova +6 more
wiley +1 more source
Research of Glycoprobe Based Cancer Immunotherapy [PDF]
, 2017 随着癌症发病率和死亡率的不断升高，有效的治疗方法具有重要的临床价值。传统治疗方法如放疗和化疗，虽在治疗初期有一定效果，但治疗后期肿瘤容易复发。机体免疫系统本身具有抗肿瘤潜力，但肿瘤细胞会通过改变表面结构逃避免疫识别，为了使免疫系统识别、杀灭自身肿瘤，人们发展了肿瘤免疫疗法。常用策略是通过基因工程的方法改造免疫细胞，使其识别肿瘤。但该方法技术难度大，成本高周期长，限制了其广泛应用。在此我们拟发展一种改变肿瘤细胞结构，引发免疫识别的新型免疫疗法。由于肿瘤细胞表面唾液酸的结构与丰度直接影响了免疫识别过程 ...
林碧娟
core
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency. However, they still face a major challenge from tumor metastasis. In this work, endogenous/exogenous dual‐responsive bimetallic hollow PdRu (termed HPdRu) nanozymes were prepared.
Nan‐Nan Zheng, Xin Hu, Jun‐Qing Hu
wiley +1 more source