Results 11 to 20 of about 4,823 (155)
Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023 Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki +4 more
wiley +1 more source
Factors that shape large‐scale gradients in clonality
Journal of Biogeography, Volume 50, Issue 5, Page 827-837, May 2023., 2023 Abstract Aim Many plant species reproduce clonally. However, ecologists still have much to learn about the factors that shape large‐scale patterns in plant clonal growth and reproduction, especially in the southern hemisphere. We addressed this knowledge gap by quantifying relationships between reproductive mode and a suite of plant characteristics and
Hongxiang Zhang +4 more
wiley +1 more source
General‐purpose genotypes and evolution of higher plasticity in clonality underlie knotweed invasion
New Phytologist, Volume 246, Issue 2, Page 758-768, April 2025.Summary Many widespread invasive plant species express high phenotypic variation across novel environments, providing a unique opportunity to examine ecological and evolutionary dynamics under global change. However, studies often lack information about the origin of introduced populations, limiting our understanding of post‐introduction evolution.
Shengyu Wang +15 more
wiley +1 more source
Long‐term use of lokivetmab in dogs with atopic dermatitis
Veterinary Dermatology, Volume 35, Issue 6, Page 683-693, December 2024.Background – Lokivetmab, a caninised monoclonal antibody against interleukin (IL)‐31, is an effective treatment for the pruritus associated with canine atopic dermatitis (cAD). Objectives – To investigate the efficacy and safety of lokivetmab during long‐term treatment defined as at least three consecutive lokivetmab injections in atopic dogs under ...
Bettina Kasper +2 more
wiley +1 more source
Taxonomy, distribution and comparative study of thermal tolerance in Nipponacmea limpets along China coast [PDF]
, 2015 作为生物圈最脆弱的系统之一，潮间带生态系统是研究全球变化对群落动态影响的理想系统。全球变化带来的环境变化如温度升高、海水酸化和海平面升高等可影响生物行为、生理以及进化适应，从而改变潮间带生物的种群动态和群落结构。而面对环境变化，物种间由于适应能力的差异，会出现“胜利者”和“失败者”。背尖贝（GenusNipponacmea）是常见潮间带生物，广泛分布于我国沿海中-高潮间带岩石上。本研究利用DNA条形码研究中国沿岸背尖贝的分类、系统发育以及地理分布格局，并测定不同温度下背尖贝属间生理和分子适应的差异 ...
于姗姗
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Zhongshan Daxue xuebao. Yixue kexue ban, 2007 [目的]克隆健康人苯丙氨酸羟化酶基因全长cDNA序列,构建并鉴定其原核表达质粒pTrcHisB/PAH。[方法]采用RT-PCR方法从人肝组织中扩增PAH基因全长cDNA,T/A克隆到pMD18-T载体中,双酶切后将cDA亚克隆入pTrcHisB载体,构建pTrcHisB/PAH质粒,经限制性内切酶鉴定并测序。[结果]人PAH基因cDNA正确克隆入pTrcHisB表达载体,与Genebank中PAH基因序列一致。[结论]成功构建pTrcHisB/PAH表达质粒 ...
张志 +8 more
doaj
Marine flavobacterium Gramella flava JLT2011 utilization polysaccharide of phytoplankton and characterization of new species of Pelagibaca bacterium [PDF]
, 2015 海洋浮游植物是海洋食物网的初级生产者，是海洋有机质重要分泌者。海洋浮游植物光合作用产生的有机质,通过海洋细菌分泌的一系列胞外酶等将颗粒有机质POM（ParticleOrganicMatter,POM）进一步代谢为生物可利用的溶解有机质（BioavailableDissolvedOrganicMatter,BDOM）。在这一个过程中噬纤维菌-黄杆菌-拟杆菌(Cytophaga-Flavobacterium-Bacteroides,CFB)菌群起着重大的作用。这类细菌形态多样，一般具有较强的运动性和粘附性 ...
林颖芳
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Zhongshan Daxue xuebao. Yixue kexue ban, 2001 【目的】用RT-PCR 法获得人类神经元性芳香族氨基酸脱羧酶(AADC)基因全序列, 并建立优化方法。【方法】 从人嗜铬细胞瘤中提取组织总RNA , 自行设计引物, 采用两步RT-PCR 法扩增出长约1 550 bp 的基因片断, 凝胶回收后与高 效克隆PCR 产物的新型载体T-载体连接, 并转化入大肠杆菌, 通过蓝白斑反应筛选出重组体, 质粒提取后进行重组体的酶切 鉴定及基因测序。【结果】BamH Ⅰ 和Hin dⅢ 酶切证实了目的基因同克隆载体进行了有效的连接, 基因测序证实了所克隆的 ...
刘 军 +3 more
doaj
Functional Study of Ecdysone Signaling Pathway Related Genes During Ovarian Maturation and Juvenile Development of The Mud Crab, Scylla paramamosain [PDF]
, 2015 蜕皮激素在节肢动物蜕皮、附肢再生以及繁殖等生理过程起着重要作用。蜕皮激素受体（Ecdysonereceptor，EcR）在整个蜕皮激素信号通路中起重要作用。当蜕皮激素合成达到一定浓度以后，能够诱导EcR与维甲酸X受体（retinoidXreceptor，RXR）形成有功能的EcR/RXR异源二聚体，进而启动蜕皮激素信号通路产生级联反应，诱导E75、E74、BroadComplex（BR-C）等早期应答基因的转录。这些早期应答基因进一步调控下游一些蛋白酶和其它基因的陆续表达，产生次级应答 ...
巩杰
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