Results 11 to 20 of about 26,684 (165)
Development of a novel fast immunoassay for HBV genotyping and study on the clinical significance of the quantitative hepatitis B core antibody level [PDF]
, 2015 乙型肝炎病毒（HepatitisBvirus,HBV）感染是一个严重的，世界范围内的公共卫生问题，可以导致肝炎，肝硬化（LC）和肝细胞癌（HCC），每年可以引起100万以上的人死亡。在HBV感染的临床诊断中，不同的HBV相关标志物指示了病毒产生，病毒多态性以及宿主免疫反应三个方面，从而全面了解HBV感染者的疾病状态，预测自然转归和治疗应答，监测疾病进展和治疗效果，对HBV感染者的管理和治疗起到关键的指导作用。目前在指示病毒产生的标志物方面，HBsAg，HBVDNA和HBeAg的检测手段相对成熟 ...
宋浏伟
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Conservation Biology, EarlyView.Abstract Despite the crucial role of human impacts on biodiversity loss, many assessments of this loss focus on single metrics, such as species richness, and overlook the multidimensional effects of human activities. Because of its importance to ecosystem functioning, we investigated the functional diversity of medium‐ and large‐sized mammal ...
Xueyou Li +8 more
wiley +1 more source
Study on epidemiology and pathogenic spectrum of HFMD cases in Xiamen, 2013-2016 [PDF]
, 2016 手足口病由肠道病毒感染引起，是一种高发于0-5岁儿童的急性传染病，其在世界范围内出现多次大规模爆发流行，仅仅在中国大陆每年就有几百万例病例。手足口病的流行给公共卫生带来了威胁。目前仅有靶向EV71的手足口病单价疫苗上市，但由于肠道病毒病原的多样性，EV71单价疫苗可能无法有效控制疫情。因此对于手足口病病原谱的监测及主要病原分子进化的研究仍然十分重要。为此，本研究在前期建立的肠道病毒诊断分型方法的基础上，进一步完善检测体系，对厦门地区手足口病肠道病毒病原谱进行了全面的监测 ...
陈梦媛
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Conservation Biology, EarlyView.Abstract Achieving global conservation policy goals requires the ability to set and measure progress toward science‐based targets for biodiversity. The species threat abatement and restoration (STAR) metric was developed to enable actors to set science‐based targets for species.
Louise Mair +17 more
wiley +1 more source
A New Type of Spacer Oligonucleotide Typing for Mycobacterium Tuberculosis Complex and Clinical Evaluation [PDF]
, 2016 结核病是当今世界范围内对人类健康最具威胁的传染性疾病之一，具有潜伏感染的特点，因此追踪传染源和查证传播途径是长期困扰结核病流行病学研究的一个问题，也是分子流行病学要解决的首要问题。基因分型技术是分子流行病学研究的一个有力工具，在研究结核病传播规律方面有着不可替代的优势。一个理想的基因分型技术应当具备简便、快速、结果可在不同实验室间进行比较等特点。本论文基于探针熔解曲线分析技术，建立新型的快速结核分枝杆菌分型体系，并评价其临床应用。论文内容如下： 第一章为绪论，首先概述了结核病目前的流行情况 ...
曾小红
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Zhongguo shiyan zhenduanxue, 2010 目的研究不同类型乙型肝炎病毒（HBV）感染者中HBV基因型分布情况及其临床意义。方法应用基因型特异性引物聚合酶链反应法（PCR）,对180份HBV感染者血清进行基因型分型。结果180份标本中,162份（90%）可检出基因型,18份（10%）未检出基因型。162份HBV基因型分布为:B基因型1例（0.6%）,C基因型159例（98.1%）,B+C混合基因型2例（1.2%）,未检出A、D、E、F基因型。结论邯郸地区HBV感染者中,基因型分布较单一,C基因型占绝对优势,同时存在少量B基因型及B+C混合基因型 ...
邓健 +6 more
doaj
Biodiversity‐driven spatial conservation planning to delineate temporally stable regions
Conservation Biology, EarlyView.Abstract The accelerating loss of biodiversity underscores the critical need for effective conservation strategies, particularly in the face of climate change and anthropogenic pressures. We devised a conservation planning framework that adopts a temporal stacking approach to species distribution models and landscape connectivity analyses. These models
Mattia Iannella +5 more
wiley +1 more source
Interference of Homologous Sequences on the SNP Study of CYP2A13 Gene [PDF]
, 2010 Background and objective It has been proven that cytochrome P450 enzyme 2A13 (CYP2A13) played an important role in the association between single nucleotide polymorphisms (SNP) and human diseases.
Chaorong MEI +7 more
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Defining and identifying relevant stakeholders to advance effective conservation
Conservation Biology, EarlyView.The challenge of defining stakeholders in environmental science and an approach for refining existing definitions. Abstract Stakeholder is a contested term that has spawned a multitude of ad hoc definitions. The ambiguity of these definitions has oftentimes impeded transdisciplinary research in environmental governance and conservation science because ...
Milan Büscher +5 more
wiley +1 more source
Study on Ensemble Algorithm for Multi-class Gene Microarray Datasets [PDF]
, 2015 集成学习是当前机器学习领域的一个研究热点，具体到多分类问题，旨在通过一组差异的分类器共同解决起初的多分类问题，然后经过大多数投票等策略将各个分类器的输出结果进行融合。集成多分类算法相比于单个的优秀分类器往往性能上更准确、更稳定，同时还具有更强的泛化能力。在解决多分类问题时，基于纠错输出编码算法（ECOC）。这是解决多分类问题的一种灵活、高效的算法框架，关键要点是将多分类转变为多个二分类问题。此外，遗传规划算法可用于解决二分类问题，通过进化计算得到准确的分类规则。本文在已有的研究基础上 ...
曾志浩
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