Results 41 to 50 of about 1,669,777 (177)
ABSTRACT Artificial intelligence (AI) has gained much interest in public administration and public policy fields in recent years. Research on and that uses AI has so far treated it as an object or context within the broader administrative and governance discourse.
Yanto Chandra, Jianxiang Tan
wiley +1 more source
目的基于等位基因特异性PCR(allele-specific PCR,AS-PCR)原理,建立一种QPCR检测CLU基因与阿尔兹海默病(AD)相关性SNP位点基因型的筛选方法。方法根据CLU基因上的rs11136000,rs2279590和rs9331888 3个SNP位点设计特异性的野生型、突变型引物,使用实时荧光定量PCR(QPCR)对AD患者外周血样本进行SNP基因分型,以DNA基因测序法结果作为参考标准。结果 10例样本的QPCR定量分型结果显示 ...
李逸豪 +8 more
doaj
ABSTRACT Heterogeneous structures have demonstrated great potential for overcoming the long‐standing strength–ductility trade‐off in metallic materials. In this study, a novel dual‐gradient structure, characterized by gradients in both grain size and precipitate distribution, was successfully constructed in an Mg–2Zn–0.8Gd (wt%) alloy sheet via sliding
Chunquan Liu +4 more
wiley +1 more source
ABSTRACT Photocatalytic hydrogen peroxide (H2O2) production from water and oxygen driven by solar energy represents a highly promising green and sustainable strategy. Herein, lignin‐derived carbon quantum dots (LCDs) were strategically introduced at the heterojunction between a Bi‐based metal organic framework (Bi‐MOF) and ZnIn2S4 (ZIS).
Wanpeng Sun +8 more
wiley +1 more source
过氧化物酶增生物-激活受体γ2基因多态性与2型糖尿病的相关性
目的探讨PPARγ2基因多态性与2型糖尿病的关系。方法以rs1875796为遗传标记,应用多聚酶链-限制性片段长度多态性(PCR-RFLP)技术检测250例2型糖尿病患者和337例健康对照人群PPARγ2基因型。结果 Rs1875796基因型频率CC:CT:TT在2型糖尿病和正常对照组的频率分布分别为2.8%:27.2%:70.0%和2.7%:25.5%:71.8%;C等位基因和T等位基因在2型糖尿病组和正常对照组的频率分布分别为16.4%:83.6%和15.4%:84.6%,两组间的等位基因 ...
高鹏, 吴江, 杜丹华, 张颖
doaj
利用基因表达谱数据进行肿瘤亚型分类,对于癌症研究有着非常重要的意义。由于基因表达数据的维数很高,必须从大量基因中选取一些特征基因用于分类,才能取得好的效果。但以往方法所提取的特征基因,彼此之间存在较高的相关性。本文提出了一种基于高维向量分析的特征基因提取方法:首先利用基因与理想基因间相似度作为评价准则得到候选集,然后去除候选集中相关性强的冗余基因。用此方法选出的特征基因是与分类相关但彼此无关的 ...
王守觉, 周凌飞
core
东北汉族人群抵抗素基因rs1862513(G/C)多态性与2型糖尿病相关性研究
目的探讨东北汉族抵抗素基因rs1862513(G/C)位点与2型糖尿病发病及临床表型相关性。方法应用连接酶反应分型法检测79例2型糖尿病患者及79例正常对照者rs1862513(G/C)多态性。结果 2型糖尿病组和对照组抵抗素rs1862513(G/C)位点基因型分布分别为GG49.5%、GC44.3%、CC6.2%和GG40.2%、GC47.4%、CC12.4%;等位基因频率分别为G型71.6%、C 28.4%和G型63.9%、C型36.1%,该位点的基因型分布和等位基因频率在两组间分布均无统计学意义(
陈珍珍 +4 more
doaj
ABSTRACT Gram‐negative (G−) bacterial infections, fueled by intrinsic antibiotic resistance stemming from their unique outer membrane architecture, pose a critical global clinical challenge. This study introduces a pioneering dual‐enzyme‐mimetic nanotherapy based on NaYbF4 nanoparticles (NaYbF4 NPs) that achieves synergistic antibacterial and anti ...
Yuxiang Zhang +6 more
wiley +1 more source
转pMThGH基因红鲤F_4代鱼体内转植基因存在的分子多态性
从一尾转pMThGH基因红鲤F4代仔鱼基因组内回收并克隆了50个转植基因(transgene),对其中33个进行了分析.根据双酶切结果,可将这些回收基因分为4种类型.用5种内切酶构建了这 4种类型回收基因的限制性内切酶图谱,第 1种类型(6个,占 18%)与建立原代转基因鱼所用的外源基因相同,而其他3种类型回收基因的分子量大小、酶切位点的种类、数量、位置都迥异于转移前的结构,意味着大多数转植基因顺序发生了缺失和重排.Southern杂交进一步证明了这一结果.对回收基因侧翼进行顺序分析 ...
曾志强,朱作言
core
ABSTRACT A synergistic strategy combining a Ti interlayer and circular beam oscillation was proposed to improve the laser weldability of 6082‐T6 aluminum alloy. The Ti interlayer suppressed porosity, eliminated columnar grains, and significantly reduced grain size by 67.7% at the weld center. Mechanistically, fine L12‐Al3Ti precipitates clearly showing
Zhongping Hou +8 more
wiley +1 more source

