Results 31 to 40 of about 22,923 (166)
Linchuang shenzangbing zazhi, 2019 目的观察慢性肾衰竭维持性血液透析（MHD）患者在N5,N10-亚甲基四氢叶酸还原酶（MTHFR）基因多态性指导下的个体化服用叶酸治疗纠正高同型半胱氨酸血症的效果。方法研究纳入93例一般状况稳定的MHD患者,分为普通治疗组和个体化治疗组。两组患者均行低通量透析,并在研究期间透析器和血流量保持前后稳定。在透析治疗基础上,普通治疗组患者均口服叶酸15 mg/d,个体化治疗组依据患者MTHFR基因型决定叶酸用量,纯合子突变型（TT）、杂合子突变型（CT）和野生型（CC）患者分别口服叶酸剂量为30 mg/d、15
CHAI Lin +3 more
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Boron Difluoride Chelated Aminoanthraquinone Photosensitizer for Type I Photodynamic Therapy
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Type I photosensitizers capable of generating cytotoxic reactive oxygen species (ROS), with reduced oxygen dependence under photoirradiation, are regarded as a promising phototherapeutic approach for hypoxic solid tumors. Herein, based on the electron donor of 9‐phenyl‐carbazole (Cz) and the electron acceptor of anthraquinone (AQ ...
Tian Zhang +8 more
wiley +1 more source
Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer [PDF]
, 2010 Background and objective Radiation sensitivity is closely related to tissue oxygen, and rh-endostatin can induce the high level of oxygen content in tumor by "normalizing" tumor angiogenesis which is associated with radiotherapy sensitivity.
Changhu LI +5 more
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Veterinary Dermatology, Volume 36, Issue 6, Page 862-869, December 2025.ABSTRACT Background Chronic cases of canine otitis externa (OE) often develop infections with Pseudomonas aeruginosa (PA). Given the organism's high level of resistance, veterinary surgeons often turn to compounded solutions. Limited data describing the stability and potency of compounded ceftazidime (CAZ) solutions are available, which may affect ...
McKenna Snidow +6 more
wiley +1 more source
通过主动诱导移植物抗宿主病使AML1-ETO基因转阴1例并文献复习
Zhongguo shiyan zhenduanxue, 2023 异基因造血干细胞移植(allo-HSCT)是目前高危组急性髓系白血病(AML)唯一可以根治的治疗手段[1]。然而，移植后复发仍是allo-HSCT后患者死亡的最主要原因[2]。通过微小残留病(MRD)监测及时发现MRD并给予抢先治疗可以有效预防移植后复发，提高长期生存率[3]。目前对于移植后MRD阳性患者的干预手段主要有供者淋巴细胞输注(DLI)、去甲基化治疗、靶向药物治疗、干扰素(IFN)等，但仍有部分患者疗效不佳[4-5]。
吴小清 +4 more
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MK2 inhibitor selectively reduces alkali burn-induced inflammation and neovascularization in cornea [PDF]
, 2016 眼化学烧伤是一类常见的眼外伤疾病，特别是在发展中国家。与酸性烧伤相比，碱性烧伤更为常见。碱性物质可快速穿透眼前房，导致慢性炎症和角膜浑浊，从而导致严重且持久的视觉缺损。尽管角膜移植手术是一项有效的治疗方法，然而其成功与否取决于角膜的炎症和新生血管是否得到控制。尽管目前有许多用于治疗角膜炎症和新生血管的药物，然而由于其有一定的副作用或仅仅通过缓解症状而非从根本途径进行治疗，因此亟须从发病机制入手寻找新的治疗办法。 持久的角膜炎症与新生血管，不仅会导致永久的视觉缺失，还会使行角膜手术的时机推迟 ...
陈艳丰
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Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis +9 more
wiley +1 more source
Activatable Ferritin Nanocomplex for Real-Time Monitoring of Caspase-3 Activation during Photodynamic Therapy（PDT） [PDF]
, 2016 随着分子影像学的发展，治疗诊断学已成为现在医学研究的热点。目前各种 先进的医学成像技术已被用在医学成像，例如光学成像，磁共振成像(MRI），单 光子发射计算机断层扫描（SPECT），正电子发射断层扫描（PET）和光声成像， 从而促进了分子成像探针和医学成像的发展。分子成像探针结构复杂，能够结合 特定生物标志物并产生成像信号用于疾病的诊断。迄今为止，一些成像探针已应 用到临床，例如18F-FDG，但是探针的低靶向性特点限制了成像探针的应用。因 此 ...
王静静
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Veterinary Dermatology, Volume 36, Issue 6, Page 825-837, December 2025.Background: Inhibition of the Janus kinase pathway is an established treatment for allergic dermatitis. Objective: To evaluate the efficacy and safety of ilunocitinib for control of pruritus in dogs with allergic dermatitis in a randomised, double‐masked clinical trial.
Sophie Forster +5 more
wiley +1 more source
用Psi2STK/GCV对鼠C6神经胶质瘤细胞作用的初步研究
Zhongguo shiyan zhenduanxue, 2005 目的研究利用基因工程包装细胞进行基因转导和药物治疗相结合来治疗脑胶质瘤的可行性。方法利用分子生物学方法构建了逆转录病毒载体STK及基因工程包装细胞psi2STK,用psi2STK细胞和丙氧鸟苷（GCV）结合对胶质瘤细胞进行了基因治疗研究。结果C6胶质瘤细胞和基因工程包装细胞与不同浓度的丙氧鸟苷（GCV）一起培养,未感染的细胞比感染的细胞对丙氧鸟苷（GCV）更为敏感。结论通过体外实验证实:逆转录病毒转导HSV-TK基因在培养C6胶质瘤细胞中,提高了其对GCV的敏感性。
梁淑媛 +3 more
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