Results 11 to 20 of about 22,923 (166)
ABSTRACT Diabetic wound infections are a common complication of diabetes, which severely impact patients' quality of life. Effective treatment of diabetic wound infections remains one major challenge in the clinic, partially due to the formation of bacterial biofilm and antibiotic resistance.
Liang Zhou +8 more
wiley +1 more source
ABSTRACT Multi‐element Prussian blue analog (PBA) nanocomposites have attracted wide attention for their superior characteristics to single‐functional nanomaterials in extensive applications of diagnosis and therapy. In this study, a novel hollow nanocomposite was designed and fabricated by embedding S2− and Ag nanoparticles into a NiCuMnFe (PBA).
Tao Ji +7 more
wiley +1 more source
Multi‐Functional S‐HA/ASTA NPs Coating on Biodegradable ZE21B Alloy for Cerebrovascular Applications
ABSTRACT Magnesium (Mg) and its alloys have attracted extensive attention of researchers in the field of cerebrovascular implants due to their good mechanical properties and biosafety. However, rapid degradation and delayed endothelialization pose challenges. To address these issues, this study introduces a multifunctional composite coating.
Aqeela Yasin +4 more
wiley +1 more source
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases
ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan +5 more
wiley +1 more source
New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics
ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu +8 more
wiley +1 more source
ABSTRACT Objective Pre‐eclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Early identification of high‐risk pregnancies in the first trimester allows preventive treatment with low‐dose aspirin. This study aimed to evaluate whether multivariable Gaussian algorithm‐based PE screening strategies, with and without
E. Bonacina +10 more
wiley +1 more source
目的探讨乙型肝炎病毒基因型分布及其对抗病毒疗效的影响。方法对183例患者进行基因分型,对应用恩替卡韦及聚乙二醇干扰素浕-2a抗病毒治疗不同基因型患者疗效进行比较。率的比较采用χ2检验。结果183例慢性乙肝患者以C基因型为主,占53.6%,其次为B基因型(35.5%),C基因型患者HBeAg阳性率(69.4%)明显高于B基因型患者(47.7 ...
徐严, 张永贵, 季尚玮, 王江滨
doaj
Sfmbt2 10th intron hosted microRNA-669e-5p/3p promote cellular apoptosis by targeting anti-apoptotic gene Bcl2 [PDF]
细胞凋亡是一个主动的由基因决定的自动结束生命的过程,对有机体的正常运行和体内稳态有重要作用。细胞凋亡一旦受到抑制,很可能导致肿瘤发生。然而,肿瘤发生发展过程中细胞凋亡调控的有关机制还不完全清楚。microRNAs(miRNAs)是一类非编码的小分子RNA,它们具有调节基因表达活性的功能,在细胞的各个进程(如细胞凋亡,分化和发育中)发挥着重要的作用。在肿瘤中miRNAs有可能通过调节与凋亡相关基因的表达,参与肿瘤细胞凋亡的调控。 miR-669e-5p和miR-669e ...
王涛
core
Negotiating Centralization: How Local Networks Reshaped Scotland's National Care Service Reform
ABSTRACT Centralizing reforms frequently diverge from their original designs, yet the processes through which this divergence occurs remain insufficiently understood. This article examines Scotland's National Care Service reform (2021–2025), a major recentralization that underwent significant modification following sustained engagement from local ...
Awais Mashkoor
wiley +1 more source

