Results 61 to 70 of about 71,543 (200)
Functional analysis of Gsc gene in amphioxus during early embryonic development [PDF]
, 2015 文昌鱼是最接近脊椎动物直接祖先的现生动物，是研究脊椎动物发育相关基因功能演化的理想模型。转录因子Goosecoid（Gsc）为Homeobox基因家族重要成员，其mRNA特异表达在脊椎动物胚胎组织者（Organizer）、脊索前板（prechordalplate）等组织区域。在爪蟾中异位表达该基因可产生类似组织者的功能，诱导胚胎第二体轴的形成，该基因还可通过抑制Wnt、BMP等信号活性，参与脊椎动物背腹轴的形成和脑的发育 ...
商留珂
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International Journal of Applied Linguistics, EarlyView.ABSTRACT Research on English‐Medium‐Instruction (EMI) highlights inadequate support for students transitioning from L1‐medium‐instruction to EMI. To date, little research has focused on how L2 students’ adaptation to an EMI environment influences their L2 learning motivation (LLM).
Kevin W. H. Tai
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的探讨大肠肿瘤p53和ki-ras基因协同突变的临床意义。方法采用免疫组化和PCR-SSCP方法,检测58例大肠肿瘤患者的良性病变、良性病变转为恶变、原发腺癌组织的p53基因、ki-ras基因的表达和突变情况。结果良性病变组与恶变组间的p53基因和Ki-ras基因的表达有显著差异,良性病变组与原发腺癌组的Ki-ras基因表达差异显著;良性病变组的p53基因与Ki-ras基因的表达呈负相关,而恶变组和原发腺癌组呈正相关。p53基因和ki-ras基因两种基因突变率无显著差异,而协同突变与淋巴结转移密切相关,
侯睿哲 +3 more
doaj
International Journal of Applied Linguistics, EarlyView.ABSTRACT Although the use of AI technologies (e.g., chatbots and automated writing evaluations (AWE)) has gained considerable attention in language learning fields in recent years, how AI technologies have been designed and implemented in language learning education, as well as their effectiveness, is understudied.
Shen Qiao +2 more
wiley +1 more source
IL-23R基因多态性与五邑地区汉族人群强直性脊柱炎的相关性分析
Zhongguo shiyan zhenduanxue, 2018 目的探讨中国五邑地区汉族人群中白细胞介素(interleukin,IL)-23R基因多态位点与强直性脊柱炎(ankylosing spondylitis,AS)发病的相关性。方法选取该地区汉族人群AS患者50例和同期健康体检者70名,采用Sequenom MassArray基因分型方法检测IL-23R基因多态位点,计算等位基因及基因型频率分布,并进行统计学分析。结果 rs10489629位点基因型频率和等位基因频率在两组间分布存在显著差异(χ2=11.392,P=0.003;χ2=13.435,P=0 ...
李秀娟 +5 more
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The study about the association of miRNA1269a SNP and the susceptibility to hepatocellular carcinoma [PDF]
, 2016 研究背景及目的： 基于早期肝癌患者缺乏特异症状和体征，而中晚期肝癌患者治疗效率又比较低并且预后较差，探讨肝癌的早期诊断与其发生机制具有重要意义。miRNA是一类由内源基因编码的长度约为22个核苷酸的非编码单链RNA分子，它们在动植物中参与转录后基因表达调控，其形成过程从长链pri-miRNAs到pre-miRNAs，最后形成成熟miRNAs，可直接结合到mRNA的3’UTR，从而抑制mRNA的翻译，导致mRNA的降解，进而影响蛋白质的表达，改变生物过程 ...
闵培
core
International Journal of Applied Linguistics, EarlyView.ABSTRACT This study conducted linguistic analyses of the written corrective feedback (WCF) for Chinese as a second language (CSL) provided by chat generative pre‐trained transformer (ChatGPT) and human teachers (including preservice teachers and senior teachers).
Ling Zhang +2 more
wiley +1 more source
Brd4-P-TEFb and SECs complexs cooperatively regulate RNA Pol II pause release via different recruitment pathways [PDF]
, 2015 真核基因转录调控是细胞基因表达调控网络的基础，细胞内编码蛋白的基因和核内小RNA（snRNA）的转录是由RNA聚合酶II（RNAPolII）负责的。RNAPolII控制的转录由前起始复合物组装、转录起始、启动子清理、转录延伸、转录终止等5步依次协同完成。正性转录延伸因子b（P-TEFb）发现之前，研究人员一直认为转录前起始复合物组装和转录起始是转录调控的关键步骤。随着人们对P-TEFb在转录调控方面研究的深入，发现转录延伸同样受到严密及精细的调控，是基因转录的限速步骤。 最近的研究表明 ...
陆小冬
core
International Journal of Applied Linguistics, EarlyView.ABSTRACT Second or foreign language (L2) speaking is a key aspect of L2 competence. While GenAI shows potential to address challenges in L2 speaking development, its role remains insufficiently understood. Self‐Determination Theory (SDT) could explain student language learning engagement. Therefore, this systematic review examines how GenAI affordances
Yanyan Catherine Lin +3 more
wiley +1 more source
PGC-1α基因Gly482Ser多态性与2型糖尿病前期的相关性研究
Zhongguo shiyan zhenduanxue, 2012 目的了解云南省昆明地区PGC-1α基因Gly482Ser多态性与2型糖尿病前期的相关性。方法采集361例糖尿病前期人群（IGR）、430例2型糖尿病患者（T2DM）和446例OGTT正常的健康志愿者（NGT）的血样,提取基因组DNA。应用高分辨率熔解曲线分析方法检测PGC-1α基因Gly482Ser基因型,观察三组人群中基因型和等位基因的分布情况,同时分析糖尿病前期不同基因型人群的临床变量的差异性。结果20（1）PGC-1α基因Gly482Ser20AA基因型及G等位基因在T2DM组中的频率分别为0 ...
邓德耀 +9 more
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